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Volume 8, Number 5—May 2002


Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine

Paola Marchisio*, Susanna Esposito*, Gian Carlo Schito†, Anna Marchese†, Roberta Cavagna*, Nicola Principi*Comments to Author , and the Hercules Project Collaborative Group
Author affiliations: *University of Milan, Milan, Italy; †University of Genoa, Genoa, Italy

Main Article

Table 2

Recovery of Streptococcus pneumoniae in the nasopharynx by age, 13 Italian cities, April 15–June 15, 2000a

Age group (% of total/age group)
Carriers <2 yrs 2-5 yrs >5 yrs Total
Total/age group 420 1,389 990 2,799
Total carriers 26 (6.2) 132 (9.5) 84 (8.5) 242 (8.6)
Carriers of invasive strains 20 (74.1) 106 (81.5) 61 (71.2) 187 (77.3)
Carriers of strains covered by the heptavalent vaccine 19 (73.1)a 91 (68.9)b 43 (51.2)ab 153 (63.2)

aCarriers <2 yrs vs. carriers >5 yrs: p=0.040.
bCarriers 2-5 yrs vs. carriers >5 yrs: p=0.0008.

Main Article

1The Hercules Project Collaborative Group includes: F. Schettini, D. De Mattia (Bari, Italy); G. P. Salvioli, G. Faldella (Bologna, Italy); G. Caramia, E. Ruffini (Ancona, Italy); E. Reali (Cinisello Balsamo, Italy); R. Longhi (Como, Italy); G. Bona (Novara, Italy); A. Guarino, F. Albano (Napoli, Italy); R. Malvicini (Fidenza, Italy); L. Ziino (Palermo, Italy); I. Barberi, T. Corona (Messina, Italy); P. Pusceddu (Cagliari, Italy); T. Meloni (Sassari, Italy); G. Saggese, and M. Migliaccio (Pisa, Italy).