Volume 9, Number 1—January 2003
Research
A Molecular Surveillance System for Global Patterns of Drug Resistance in Imported Malaria
Annie-Claude Labbé*, Samir N. Patel*, Ian Crandall*, and Kevin C. Kain*
Table 2
Proportions of falciparum isolates with chloroquine- or sulfadoxine-pyrimethamine-associated resistance markers by year of acquisitiona
| Year | ||||||||
|---|---|---|---|---|---|---|---|---|
| Proportions of mutant isolates |
Proportions of isolates with at least
2 mutant codons |
|||||||
| pfmdr1 (N86Y)b | pfcrt (K76T) | dhfrc | dhpsd | |||||
| 1994 |
42.9% |
9/21 |
71.4% |
15/21 |
45.5% |
10/22 |
14.3% |
3/21 |
| 1995 |
25.0% |
2/8 |
55.6% |
5/9 |
62.5% |
5/8 |
33.3% |
3/9 |
| 1996 |
31.6% |
6/19 |
50.0% |
9/18 |
52.4% |
11/21 |
25.0% |
5/20 |
| 1997 |
52.9% |
9/17 |
66.7% |
10/15 |
88.2% |
15/17 |
35.3% |
6/17 |
| 1998 |
64.3% |
9/14 |
50.0% |
7/14 |
85.7% |
12/14 |
21.4% |
3/14 |
| 1999 |
50.0% |
7/14 |
64.3% |
9/14 |
78.6% |
11/14 |
57.1% |
8/14 |
| 2000e |
71.4% |
5/7 |
57.1% |
4/7 |
50.0% |
3/6 |
42.9% |
3/7 |
| Total |
47.0% |
47/100 |
60.2% |
59/98 |
65.7% |
67/102 |
30.4% |
31/102 |
| (95% CI) | (36.9 to 57.2) | (49.8 to 70.0) | (54.6 to 3.9) | (21.7 to 40.3) | ||||
aOR, odds ratio; CI, confidence interval.
bOR for a 1-unit increase in year = 1.21 (95% CI 0.99 to 1.49); p=0.07, chi-square test for trend.
cOR for a 1-unit increase in year = 1.28 (95% CI 1.0 to 1.59); p=0.02, chi-square test for trend.
dOR for a 1-unit increase in year = 1.29 (95% CI 1.03 to 1.61); p=0.03, chi-square test for trend.
eData for year 2000 are from January 1 to June 30.
Page created: December 07, 2010
Page updated: December 07, 2010
Page reviewed: December 07, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
Content Credential