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Volume 9, Number 10—October 2003
Dispatch

Severe Histoplasmosis in Travelers to Nicaragua

Michelle Weinberg*Comments to Author , Julia Weeks†, Susan Lance-Parker‡, Marc Traeger*§, Steven Wiersma§, Quyen N. Phan¶, David Dennison#, Pia MacDonald***, Mark Lindsley*, Jeannette Guarner*, Patricia Connolly††, Martin S. Cetron*, and Rana Hajjeh*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Archbold Urgent Care Center, Thomasville, Georgia, USA; ‡Georgia Department of Human Resources, Division of Public Health, Atlanta, Georgia, USA; §Florida Department of Health, Tallahassee, Florida, USA; ¶Connecticut Department of Public Health, Hartford, Connecticut, USA; #Highlands-Cashiers Hospital, Highlands, North Carolina, USA; **North Carolina Division of Public Health, Raleigh, North Carolina, USA; ††Indiana University School of Medicine and Histoplasmosis Reference Laboratory, Indianapolis, Indiana, USA

Main Article

Table

Summary of laboratory testing results and clinical outcomes among persons with histoplasmosis

Characteristic N (%)
Diagnostic test resulta
CFb and IDc positive
 5 (36)
CF positive, ID negative
 8 (57)
ID positive, CF negative
 1 (7)
Urine antigen positived
 7 (58), range 1.2–4.6, median 2.8
Clinical outcomese
Missed work, school, or bothf
 10 (83)
Treated with itraconazole
 9 (75)
Treated with steroids
 7 (58)
Hospitalized
 6 (50)
Duration of hospitalization
 Median 6 d (range 2–11 d)
Duration of fever
 Median 12 d (range 4–26 d)
Duration of symptoms Median 42 d (range 16–210 d)

aAmong 14 persons with histoplasmosis.
bCF: complement fixation.
cID: immunodiffusion.
dUrine antigen tests were performed for 12 persons.
eAmong the 12 symptomatic persons.
fFive persons missed 2 weeks–3 months of work, and five persons missed one semester of school.

Main Article

Page created: January 10, 2011
Page updated: January 10, 2011
Page reviewed: January 10, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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