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Volume 9, Number 8—August 2003

Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis

Peter G.W. Plagemann*Comments to Author 
Author affiliation: *University of Minnesota, Minneapolis, Minnesota, USA

Main Article

Figure 4

Nucleotide alignment of a segment of open reading frame (ORF) 1b of lactate dehydrogenase-elevating virus–P, porcine reproductive and respiratory syndrome virus VR-2332, and porcine reproductive and respiratory syndrome virus–Lelystad virus beginning at nucleotides 1169, 1165, and 1165, respectively. *Indicates identical nucleotides. Degenerate primer sets for polymerase chain reaction were previously made to the underlined segments (41).

Figure 4. Nucleotide alignment of a segment of open reading frame (ORF) 1b of lactate dehydrogenase-elevating virus–P, porcine reproductive and respiratory syndrome virus VR-2332, and porcine reproductive and respiratory syndrome virus–Lelystad virus beginning at nucleotides 1169, 1165, and 1165, respectively. *Indicates identical nucleotides. Degenerate primer sets for polymerase chain reaction were previously made to the underlined segments (41).

Main Article

  1. Morse  S. Crossing over: the interspecies traffic of emerging infections. J NIH Res. 1994;6:526.
  2. Nathanson  N. The emergence of infectious diseases: societal causes and consequences. ASM News. 1996;63:838.
  3. Collins  J, Benfield  D, Christianson  W, Harris  L, Hennings  J, Shaw  D, Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J Vet Diagn Invest. 1992;4:11726.PubMed
  4. Wensvoort  G. Lelystad virus and the porcine epidemic abortion and respiratory syndrome. Vet Res. 1993;24:11724.PubMed
  5. Benfield  D, Collins  J, Dee  S, Halbur  P, Joo  H, Lager  K, Porcine reproductive and respiratory syndrome. In: Straw BE, D’Allaire S, Mengeling WL, Taylor DJ, editors. Diseases of the swine. 8th ed. Ames, Iowa: Iowa State University Press; 1999. p. 201–32.
  6. Cavenagh  D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol. 1997;142:62933.PubMed
  7. Nelsen  C, Murtaugh  M, Faaberg  K. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J Virol. 1999;73:27080.PubMed
  8. Hill  H, Owen  W, Eernisse  K, Zimmerman  J, Uhlenhopp  E, Frey  M. Prevalence of SIRS in Iowa swine herds. American Association Swine Practitioners News. 1992;1992:47.
  9. Ohlinger  V. PRRS/Blue ear disease. In: Meredith M, editor. SIRS monthly newsletter. Cambridge: Pig Disease Information Center; December 1992.
  10. Plagemann  P. Lactate dehydrogenase-elevating virus and related viruses. In: Fields BN, Knipe DM, Howley PM, editors. Virology. 3rd edition. New York: Raven Press; 1996. p. 1105–20.
  11. Dea  S, Ganon  C, Mardassi  H, Pirzadeh  B, Rogan  D. Current knowledge on the structural proteins for porcine reproductive and respiratory syndrome (PRRS) virus: comparison of the North American and European isolates. Arch Virol. 2000;145:65968. DOIPubMed
  12. Meulenberg  J. PRRSV, the virus. Vet Res. 2000;31:1121. DOIPubMed
  13. Faaberg  K, Plagemann  P. The envelope proteins of lactate dehydrogenase-elevating virus and their membrane topography. Virology. 1995;212:51225. DOIPubMed
  14. Faaberg  K, Even  C, Palmer  G, Plagemann  P. Disulfide bonds between two envelope proteins of lactate dehydrogenase-elevating virus are essential for viral infectivity. J Virol. 1995;69:6137.PubMed
  15. Dobbe  J, van der Meer  Y, Spaan  W, Snijder  E. Construction of chimeric arteriviruses reveals that the ectodomain of the major glycoprotein is not the main determinant of equine arteritis tropism in cell culture. Virology. 2001;288:28394. DOIPubMed
  16. Verheide  M, Welting  T, Jansen  H, Rottier  P, Meulenberg  J. Chimeric arteriviruses generated by swapping of the M protein ectodomain rule out a role of this domain in viral targeting. Virology. 2002;303:36473. DOIPubMed
  17. Rowson  K, Mahy  B. Lactic dehydrogenase virus. Virol Monogr. 1975; 13.PubMed
  18. Plagemann  P, Chen  Z, Li  K. Polylactosaminoglycan chains on the ectodomain of the primary envelope glycoprotein of an arterivirus determine its neuropathogenicity, sensitivity to antibody neutralization and immunogenicity of the neutralization epitope. Curr Top Virol. 1999;1:2743.
  19. Plagemann  P. Complexity of the single linear neutralization epitope of the mouse arterivirus lactate dehydrogenase-elevating virus. Virology. 2001;290:1120. DOIPubMed
  20. Cafruny  W, Hovinen  D. The relationship between route of infection and minimum infectious dose: studies with lactate dehydrogenase-elevating virus. J Virol Methods. 1988;20:26570. DOIPubMed
  21. Li  K, Schuler  T, Chen  Z, Glass  G, Childs  J, Plagemann  P. Isolation of lactate dehydrognease-elevating viruses from wild house mice and their biological and molecular characterization. Virus Res. 2000;67:15362. DOIPubMed
  22. Plagemann  P, Chen  Z, Li  K. Replication competition between lactate dehydrogenase-elevating virus quasispecies in mice: implications for quasispecies selection and evolution. Arch Virol. 2001;146:128396. DOIPubMed
  23. Holland  J, Domingo  E. Origin and evolution of viruses. Virus Genes. 1998;16:1321. DOIPubMed
  24. Ostrowski  M, Galeota  J, Jar  A, Platt  K, Osorio  F, Lopez  O. Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain. J Virol. 2002;76:424150. DOIPubMed
  25. Plagemann  P, Rowland  R, Faaberg  K. The primary neutralization epitope of porcine reproductive and respiratory syndrome virus is located in the middle of the GP5 ectodomain. Arch Virol. 2002;147:232747. DOIPubMed
  26. Mayer  J, Brisbin  I. Wild pigs of the United States: their biology, history, morphology and current status. Athens (GA): The University of Georgia Press; 1991.
  27. Stadejek  T, Stankevicius  A, Storgaard  T, Oleksiewicz  M, Drew  T, Pesak  Z. Identification of radically different variants of porcine reproductive and respiratory syndrome virus in Eastern Europe: towards a common ancestor for European and American viruses. J Gen Virol. 2002;83:186173.PubMed
  28. Forsberg  R, Storgard  T, Nielsen  H, Oleksiewicz  M, Cardioli  P, Sala  G, The genetic diversity of European type PRRSV is similar to that of the North American type but is geographically skewed within Europe. Virology. 2002;299:3847. DOIPubMed
  29. Christianson  W, Joo  H-S. Porcine reproductive and respiratory syndrome: a review. Swine Health Prod. 1994;2:1028.
  30. Lindhaus  W, Lindhaus  B. Raetselhafte Schweinekrankheit. Prakt Tierarzt. 1991;5:4235.
  31. Forsberg  R, Oleksiewiez  M, Peterson  A, Hein  J, Botner  A, Storgaard  T. A molecular clock dates the common ancestor of European-type porcine reproductive and respiratory syndrome virus at more than 10 years before emergence of disease. Virology. 2001;289:1749. DOIPubMed
  32. Oslage  U, Dahle  J, Mueller  T, Kramer  M, Liess  B. Praevalenz von Antikoerpern gegen die Viren der Europaeischen Schweinepest,der Aujeszky’schen Krankheit and des” porcine reproductive and respiratory syndrome”(PRRS) bei Wildschweinen in den Bundeslaendern Sachsen-Anhalt und Brandenburg. Dtsch Tierarztl Wochenschr. 1994;101:338.PubMed
  33. Albina  E, Mesplede  A, Chenut  G, Le Potier  M, Bourba  G, Le Gal  S, A serological survey on classical swine fever (CSF), Aujeszky’s disease (AD) and porcine reproductive and respiratory syndrome (PRRS) virus infections in French wild boars from 1991 to 1998. Vet Microbiol. 2000;77:4357. DOIPubMed
  34. Saliki  J, Rodgers  S, Eskew  G. Serosurvey of selected viral and bacterial diseases in wild swine from Oklahoma. J Wildl Dis. 1998;34:8348.PubMed
  35. Gibson  P, Veatc  J, Matlack  R, Jones  D. Health status of a recently discovered population of feral swine in Kansas. J Wildl Dis. 1999;35:6247.PubMed
  36. Zupancic  Z, Jukic  B, Lojkic  M, Cac  Z, Staresina  V. Prevalence of antibodies to classical swine fever, Aujeszky’s disease, porcine reproductive and respiratory syndrome, and bovine viral diarrhea viruses in wild boars in Croatia. J Vet Med B Infect Dis Vet Public Health. 2002;49:2536. DOIPubMed
  37. Vincent  J, Leon-Vizcaino  L, Gortazar  C, Cubero  M, Gonzales  M, Martin-Atance  P. Antibodies to selected viral and bacterial pathogens in European boars from southwestern Spain. J Wildl Dis. 2002;38:64952.PubMed
  38. Cafruny  W, Chan  S, Harty  J, Yousefi  S, Kowalchyk  K, McDonald  D, Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus. Virus Res. 1986;5:35775. DOIPubMed
  39. Harty  J, Chan  S, Plagemann  P. Characteristics of monoclonal antibodies to the lactate dehydrogenase-elevating virus. Intervirology. 1987;27:5360. DOIPubMed
  40. Coutelier  J, van Roost  F, Lambotte  P, van Snick  J. The murine antibody response to lactate dehydrogenase-elevating virus. J Gen Virol. 1986;67:1099108. DOIPubMed
  41. Chen  Z, Plagemann  P. Detection of related positive strand RNA virus genomes by reverse transcription/polymerase chain reaction using degenerate primers for common replicase sequences. Virus Res. 1995;39:36575. DOIPubMed

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