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Volume 10, Number 11—November 2004
Perspective

Trachoma Decline and Widespread Use of Antimicrobial Drugs

Jaya D. Chidambaram*, Mariko Bird*, Vivian Schiedler*, Alicia M. Fry†, Travis Porco‡, Ramesh C. Bhatta§, Hem Jha§, J.S.P. Chaudary§, Bruce Gaynor*, Elizabeth Yi*, John P. Whitcher*, Susie Osaki-Holm*, and Thomas M. Lietman*Comments to Author 
Author affiliations: *University of California, San Francisco, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡California Department of Health Services, Berkeley, California, USA; §Geta Eye Hospital, Geta, Nepal

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Figure 1

Antimicrobial drug use in Geta, Nepal. Antimicrobial drug sales in a 3-month period (mid-February to mid-May 2000) from all pharmacies in the Geta subdistrict, expressed as defined daily doses (DDDs) and as a percentage of the total DDDs sold (6). The shaded region represents antimicrobial drugs that are effective against Chylmydia trachomatis.

Figure 1. Antimicrobial drug use in Geta, Nepal. Antimicrobial drug sales in a 3-month period (mid-February to mid-May 2000) from all pharmacies in the Geta subdistrict, expressed as defined daily doses (DDDs) and as a percentage of the total DDDs sold (6). The shaded region represents antimicrobial drugs that are effective against Chylmydia trachomatis.

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References
  1. Dolin  PJ, Faal  H, Johnson  GJ, Minassian  D, Sowa  S, Day  S, Reduction of trachoma in a sub-Saharan village in absence of a disease control programme. Lancet. 1997;349:15112. DOIPubMedGoogle Scholar
  2. Pokhrel  G, Baral  K, Boulter  A, Regmi  G. Study of community trachoma control programs in Banke, Bardia, and Kailali Districts of western Nepal. In: XVI Congress of Asia Pacific Academy of Ophthalmology. Katmandu, Nepal: Asian Pacific Academy of Ophthalmology; 1997.
  3. Taylor  H. Towards the global elimination of trachoma. Nat Med. 1999;5:4923. DOIPubMedGoogle Scholar
  4. Hoechsmann  A, Metcalfe  N, Kanjaloti  S, Godia  H, Mtambo  O, Chiopeta  T, Reduction of trachoma in the absence of antibiotic treatment: evidence from a population-based survey in Malawi. Ophthalmic Epidemiol. 2001;8:14553. DOIPubMedGoogle Scholar
  5. Jha  H, Chaudary  J, Bhatta  R, Miao  Y, Osaki-Holm  S, Gaynor  B, Disappearance of trachoma in western Nepal. Clin Infect Dis. 2002;35:7658. DOIPubMedGoogle Scholar
  6. Schiedler  V, Bhatta  RC, Miao  Y, Bird  M, Jha  H, Chaudary  J, Pattern of antibiotic use in a trachoma-endemic region of Nepal: implications for mass azithromycin distribution. Ophthalmic Epidemiol. 2003;10:316. DOIPubMedGoogle Scholar
  7. World Health Organization. Report of the first meeting of the Who Alliance for the Global Elimination of Trachoma. Geneva: The Organization; 1997.
  8. Thylefors  B, Dawson  CR, Jones  BR, West  SK, Taylor  HR. A simple system for the assessment of trachoma and its complications. Bull World Health Organ. 1987;65:47783.PubMedGoogle Scholar
  9. Holm  SO, Jha  HC, Bhatta  RC, Chaudhary  JS, Thapa  BB, Davis  D, Comparison of two azithromycin distribution strategies for controlling trachoma in Nepal. Bull World Health Organ. 2001;79:194200.PubMedGoogle Scholar
  10. Ridgway  G. Treatment of chlamydial genital infection. J Antimicrob Chemother. 1997;40:3114. DOIPubMedGoogle Scholar
  11. Suchland  RJ, Geisler  WM, Stamm  WE. Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp. Antimicrob Agents Chemother. 2003;47:63642. DOIPubMedGoogle Scholar
  12. Anatomical therapeutic chemical classification index with defined daily doses. 3rd ed. Oslo, Norway: WHO Collaborating Centre for Drug Statistics Methodology and the Nordic Council on Medicines; 2000.
  13. Lietman  T, Porco  T, Dawson  C, Blower  S. Global elimination of trachoma: how frequently should we administer mass chemotherapy? Nat Med. 1999;5:5726. DOIPubMedGoogle Scholar
  14. Muñoz  B, West  S. Trachoma: the forgotten cause of blindness. Epidemiol Rev. 1997;19:20517.PubMedGoogle Scholar
  15. Taylor  HR. A trachoma perspective. Ophthalmic Epidemiol. 2001;8:6972. DOIPubMedGoogle Scholar
  16. Emerson  PM, Cairncross  S, Bailey  RL, Mabey  DC. Review of the evidence base for the ‘F’ and ‘E’ components of the Safe Strategy for Trachoma Control. Trop Med Int Health. 2000;5:51527. DOIPubMedGoogle Scholar
  17. Mabey  D, Fraser-Hurt  N. Trachoma. BMJ. 2001;323:21821. DOIPubMedGoogle Scholar
  18. Gaynor  BD, Yi  E, Lietman  T. Rationale for mass antibiotic distribution for trachoma elimination. Int Ophthalmol Clin. 2002;42:8592.PubMedGoogle Scholar
  19. Lewallen  S, Courtright  P. Blindness in Africa: present situation and future needs. Br J Ophthalmol. 2001;85:897903. DOIPubMedGoogle Scholar
  20. Emerson  PM, Lindsay  SW, Walraven  GE, Faal  H, Bøgh  C, Lowe  K, Effect of fly control on trachoma and diarrhoea. Lancet. 1999;353:14013. DOIPubMedGoogle Scholar
  21. West  S, Muñoz  B, Lynch  M, Kayongoya  A, Chilangwa  Z, Mmbaga  BB, Impact of face-washing on trachoma in Kongwa, Tanzania. Lancet. 1995;345:1558. DOIPubMedGoogle Scholar
  22. West  SK, Muñoz  B, Lynch  M, Kayongoya  A, Mmbaga  BB, Taylor  HR. Risk factors for constant, severe trachoma among preschool children in Kongwa, Tanzania. Am J Epidemiol. 1996;143:738.PubMedGoogle Scholar
  23. Taylor  HR, West  SK, Mmbaga  BB, Katala  SJ, Turner  V, Lynch  M, Hygiene factors and increased risk of trachoma in central Tanzania. Arch Ophthalmol. 1989;107:18215.PubMedGoogle Scholar
  24. Emerson  PM, Bailey  RL, Mahdi  OS, Walraven  GE, Lindsay  SW. Transmission ecology of the fly Musca sorbens, a putative vector of trachoma. Trans R Soc Trop Med Hyg. 2000;94:2832. DOIPubMedGoogle Scholar
  25. Emerson  PM, Lindsay  SW, Alexander  N, Bah  M, Dibba  SM, Faal  HB, Role of flies and provision of latrines in trachoma control: cluster-randomised controlled trial. Lancet. 2004;363:10938. DOIPubMedGoogle Scholar
  26. Bailey  RL, Arullendran  P, Whittle  HC, Mabey  DC. Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Lancet. 1993;342:4536. DOIPubMedGoogle Scholar
  27. Dawson  CR, Schachter  J, Sallam  S, Sheta  A, Rubinstein  RA, Washton  H. A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children. Clin Infect Dis. 1997;24:3638. DOIPubMedGoogle Scholar
  28. Schachter  J, West  SK, Mabey  D, Dawson  CR, Bobo  L, Bailey  R, Azithromycin in control of trachoma. Lancet. 1999;354:6305. DOIPubMedGoogle Scholar
  29. Ministry of Health, Child Health Division. Technical guidelines on the control of acute respiratory infections. Kathmandu: Government of Nepal; 1994.
  30. Integrated management of childhood illness information: adaptation of the integrated management of childhood illness technical guidelines and training materials. WHO/CAS/CAH/98.1D/REV.1/1999. WHO and UNICEF; 1999.
  31. Regional Malaria Database. Drug regimen South East Asia region [database on the Internet]. World Health Organization, Regional Office for South East Asia (India); 2001 [cited 2004 Nov]. Available from http://w3.whosea.org/malaria/database6.htm

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Page updated: April 22, 2011
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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