Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 10, Number 12—December 2004
Research

Identifying Rodent Hantavirus Reservoirs, Brazil

Akemi Suzuki*Comments to Author , Ivani Bisordi*, Silvana Levis†, Jorge Garcia†, Luiz E. Pereira*, Renato P. Souza*, Teresa K.N. Sugahara*, Noemi Pini†, Delia Enria†, and Luiza T. M. Souza*
Author affiliations: *Instituto Adolfo Lutz–São Paulo, São Paulo, Brazil; †Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Pergamino, Argentina

Main Article

Figure 3

Phylogenetic relationship between newly and previously characterized Brazilian hantaviruses, using a 139-nt region of the M genomic segment G2 encoding region. Maximum Parsimony analysis was performed, using the heuristic search option. Bootstrap values of >50%, obtained from 500 replicates of the analysis are shown. Abbreviations and GenBank accession numbers of the previously published sequences of the hantaviruses used in this study: Araraquara-AF307327 and Castelo dos Sonhos-AF307326; Juq

Figure 3. Phylogenetic relationship between newly and previously characterized Brazilian hantaviruses, using a 139-nt region of the M genomic segment G2 encoding region. Maximum Parsimony analysis was performed, using the heuristic search option. Bootstrap values of >50%, obtained from 500 replicates of the analysis are shown. Abbreviations and GenBank accession numbers of the previously published sequences of the hantaviruses used in this study: Araraquara-AF307327 and Castelo dos Sonhos-AF307326; Juquitiba, JUQ (19).

Main Article

References
  1. Schmaljohn  CS, Hasty  SE, Dalrymple  JM, LeDuc  JW, Lee  HW, von Bonsdorff  CH, Antigenic and genetic properties of viruses linked to haemorrhagic fever with renal syndrome into a newly defined genus of Bunyaviridae. Science. 1985;227:1041–4. DOIPubMedGoogle Scholar
  2. Schmaljohn  C, Hjelle  B. Hantavirus: a global disease problem. Emerg Infect Dis. 1997;3:95–104. DOIPubMedGoogle Scholar
  3. Peters  CJ. Hantavirus pulmonary syndrome in the Americas. In: Scheld WM, Craig WA, Hughes JM, editors. Emerging infections 2. Washington: ASM Press, 1998. p. 17–64.
  4. Nichol  ST, Spiropoulou  CF, Morzunov  S, Rollin  PE, Ksiazek  TG, Feldmann  H, Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science. 1993;262:914–7. DOIPubMedGoogle Scholar
  5. Plyusnin  A, Vapalahti  O, Vaheri  A. Hantaviruses: genome structure, expression and evolution. J Gen Virol. 1996;77:2677–87. DOIPubMedGoogle Scholar
  6. Elliott  RM. Molecular biology of the Bunyaviridae. J Gen Virol. 1990;71:501–2. DOIPubMedGoogle Scholar
  7. Childs  JE, Ksiazek  TG, Spiropoulou  CF, Krebs  JW, Morzunov  S, Maupin  GO, Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis. 1994;169:1271–80. DOIPubMedGoogle Scholar
  8. LeDuc J. Epidemiology of Hantaan and related viruses. Lab Anim Sci. 1987;37:413–8.PubMedGoogle Scholar
  9. Ksiazek  TG, Peters  CJ, Rollin  PE, Zaki  S, Nichol  S, Spiropoulou  C, Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg. 1995;52:117–23.PubMedGoogle Scholar
  10. Wells  RM, Sosa Estani  S, Yadon  ZE, Enria  D, Padula  P, Pini  N, An unusual Hantavirus outbreak in Southern Argentina: person-to-person transmission? Emerg Infect Dis. 1997;3:1–5. DOIPubMedGoogle Scholar
  11. Padula  PJ, Edelstein  A, Miguel  SD, Lopez  NM, Rossi  CM, Rabinovich  RD. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology. 1998;241:323–30. DOIPubMedGoogle Scholar
  12. Galeno  H, Mora  J, Villagra  E, Fernandez  J, Hernandez  J, Mertiz  GJ, First human isolate of hantavirus (Andes virus) in the Americas. Emerg Infect Dis. 2002;8:657–61.PubMedGoogle Scholar
  13. Le Duc  JW, Smith  GA, Pinheiro  FP, Vasconcelos  PFC, Travassos da Rosa  ES, Maiztegui  JI. Isolation of Hantaan-related virus from Brazilian rats and serologic evidence of its widespread distribution in South America. Am J Trop Med Hyg. 1985;34:810–5.PubMedGoogle Scholar
  14. Hindrichsen  S, Medeiros de Andrade  A, Clement  J, Leirs  H, McKenna  P, Matthy  P, Hantavirus infection in Brazilian patients from Recife with suspected leptospirosis. Lancet. 1993;341:50. DOIPubMedGoogle Scholar
  15. Iversson  LB, Travassos da Rosa  APA, Rosa  MDB, Lomar  AV, Saski  M, LeDuc  JW. Infecção humana por hantavírus nas regiões Sul e Sudeste do Brasil. Rev Assoc Med Bras. 1994;40:85–92.PubMedGoogle Scholar
  16. Vasconcelos  PFC, Travassos da Rosa  ES, Travassos da Rosa  APA, Travassos da Rosa  JFS. Evidence of circulating hantaviruses in Brazilian Amazonia through high prevalence of antibodies in residents of Manaus, Brazil. Cienc Cult. 1992;44:162–3.
  17. Da Silva  MV, Vasconcelos  MJ, Hidalgo  NTR, Veiga  APR, Canzian  M, Marotto  PC, Hantavirus pulmonary syndrome. Report of the first three cases in São Paulo, Brazil. Rev Inst Med Trop Sao Paulo. 1997;39:231–4.PubMedGoogle Scholar
  18. Vasconcelos  MJ, Lima  V, Iversson  L, Rosa  M, Travassos da Rosa  E, Travassos da Rosa  A, Hantavirus pulmonary syndrome in the rural area of Juquitiba, São Paulo, Metropolitan Area, Brasil. Rev Inst Med Trop Sao Paulo. 1997;39:237–8.PubMedGoogle Scholar
  19. Monroe  MC, Morzunov  SP, Johnson  AM, Bowen  MD, Artsob  H, Yates  T, Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America and comparison with other hantaviruses. Emerg Infect Dis. 1999;5:75–86. DOIPubMedGoogle Scholar
  20. Johnson  AM, Souza  LTM, Ferreira  IB, Pereira  LE, Ksiazek  TG, Rollin  PE, Genetic investigation of novel hantaviruses causing fatal HPS in Brazil. J Med Virol. 1999;59:527–35. DOIPubMedGoogle Scholar
  21. Feldmann  H, Sanchez  A, Morzunov  S, Spiropoulou  CF, Rollin  PE, Ksiazek  TG, Utilization of autopsy tissue RNA for the synthesis of nucleocapsid antigen of a newly recognized virus associated with Hantavirus pulmonary syndrome. Virus Res. 1993;30:351–67. DOIPubMedGoogle Scholar
  22. Tavares  LMS, Elkhouri  MR, Lanzieri  TN, Dias  RF, Hilleshein  N, Caldas  AC, Investigation of a cluster of hantavirus infection among family members in a household in Southern Brazil. Abstracts of the Fifth International Conference on Hemorrhagic Fever with Renal Syndrome (HFRS), Hantavirus Pulmonary Syndrome (HPS), and Hantaviruses, Annecy, France, 2001. Lyon, France: Fondation Mérieux; 2001. p. 189.
  23. Mills  JN, Yates  TL, Childs  JE, Parmenter  RR, Ksiazek  TG, Rollin  PE, Guidelines for working with rodents potentially infected with hantavirus. J Mammal. 1995;76:716–22. DOIGoogle Scholar
  24. Spiropoulou  CF, Morzunov  S, Feldmann  H, Sanchez  A, Peters  CJ, Nichol  ST. Genome structure and variability of a virus causing hantavirus pulmonary syndrome. Virology. 1994;200:715–23. DOIPubMedGoogle Scholar
  25. Levis  SC, Morzunov  SP, Rowe  JE, Enría  DA, Pini  N, Calderón  G, Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis. 1998;177:529–38. DOIPubMedGoogle Scholar
  26. Johnson  AM, Bowen  MD, Ksiazek  TG, Williams  RJ, Bryan  RT, Mills  JN, Laguna Negra Virus associated with HPS in Western Paraguay and Bolivia. Virology. 1997;238:115–27. DOIPubMedGoogle Scholar
  27. Thompson  JD, Higgins  DG, Gibson  TJ. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choices. Nucleic Acids Res. 1994;22:4673–80. DOIPubMedGoogle Scholar
  28. Swofford  DL. PAUP*: Phylogenetic Analysis Using Parsimony (and other methods), v. 4.0b4a. Sunderland (MA): Sinauer Associates, Inc.; 2000.
  29. Kumar  S, Tamura  K, Jakobsen  IB, Nei  M. MEGA2: Molecular evolutionary genetics analysis software. Tempe (AZ): Arizona State University; 2001.
  30. Morelli  ML, Souza  RLM, Badra  SJ, Pinto  AA, Figueiredo  LTM. Phylogenetic study of the M segment of hantavirus from patients having cardiopulmonary syndrome. In: XIII National Meeting of Virology. Virus Rev Res. 2002;7:68.
  31. Souza  RLM, Morelli  ML, Badra  SJ, Pinto  AA, Figueiredo  LTM. Phylogenetic study of the S segment of hantavirus from patients having cardiopulmonary syndrome. In: XIII National Meeting of Virology. Virus Rev Res. 2002;7:91–2.
  32. Katz  G, Williams  RJ, Burt  MS, Souza  LTM, Pereira  LE, Mills  JN, Hantavirus pulmonary syndrome in the State of São Paulo, Brazil, 1993–1998. Vector Borne Zoonotic Dis. 2001;1:181–9. DOIPubMedGoogle Scholar
  33. Souza  LTM, Suzuki  A, Pereira  LE, Ferreira  IB, Souza  RP, Cruz  AS, Identification of hantavirus rodent reservoirs species in south and southeastern Brazil. Short communication. Informe Epidemiológico do SUS/Centro Nacional de Epidemiologia, coord. Brasília: Ministério da Saúde. Fundação Nacional de Saúde. 1999;11:249–51.
  34. Levis  S, Rowe  J, Morzunov  S, Enria  DA, St Jeor  S. New hantaviruses causing hantavirus pulmonary syndrome in central Argentina. Lancet. 1997;349:998–9. DOIPubMedGoogle Scholar
  35. Bohlman  MC, Morzunov  SP, Meissner  J, Taylor  MB, Ishibashi  K, Rowe  J, Analysis of hantavirus genetic diversity in Argentina: S segment-derived phylogeny. J Virol. 2002;76:3765–73. DOIPubMedGoogle Scholar
  36. Plyusnin  A, Morzunov  SP. Virus evolution and genetic diversity of hantaviruses and their rodent hosts. In: Schmaljohn CS, Nichol ST, editors. Hantaviruses (Curr Top Microbiol Immunol 256). Berlin: Springer-Verlag; 2001. p. 47–75.
  37. Morzunov  SP, Rowe  JE, Monroe  MC, Ksiazek  TG, Peters  CJ, St. Jeor  SC, Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol. 1998;72:57–64.PubMedGoogle Scholar
  38. Streilen  KE. Ecology of small mammals in the Semiarid Brazilian Caatinga I. Climate and faunal composition. Andrew Carnegie Museum. 1982;51:79–106.

Main Article

Page created: April 14, 2011
Page updated: April 14, 2011
Page reviewed: April 14, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external