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Volume 10, Number 5—May 2004

Research

Genetic Variation of SARS Coronavirus in Beijing Hospital

Dongping Xu*, Zheng Zhang*, Fuliang Chu*, Yonggang Li*, Lei Jin*, Lingxia Zhang*, George F. Gao†, and Fu-Sheng Wang*Comments to Author 
Author affiliations: *Beijing 302 Hospital, Beijing, China; †University of Oxford, Headington, Oxford, United Kingdom

Main Article

Table 2

Variation in S-gene sequences from 20 individual SARS patientsa,b

Pt. no. Samp. no. 21494
 21702
 21858
 22908
 23198
 24018
 24247
 24469
 24540
C→T A→G A→T A→G T→C A→T T→C A→G A→G
1
 SW6
 –
 –
 –
 –
 –
 –
 –
 –
 –
2
 SW17
 9/2c
 +
 –
 –
 –
 –
 +
 –
 –
3
 PL1
 8/39
 8/43
 48/2
 +
 +
 +
 +
 +
 +
4
 PL10
 14/7
 +
 –
 +
 +
 2/8
 +
 +
 +
PL17
 +
 +
 –
 –
 –
 +
 +
 +
 +
SP4
 –
 +
 –
 +
 –
 +
 +
 +
 +
5
 PL9
 +
 +
 –
 +
 +
 +
 +
 +
 +
SP1
 –
 +
 –
 +
 +
 –
 +
 +
 +
6
 PL5
 –
 +
 –
 +
 +
 8/4
 +
 +
 +
SP9
 –
 +
 –
 +
 +
 +
 +
 +
 +
7
 PL7
 –
 +
 –
 +
 +
 4/6
 +
 +
 +
8
 PL8
 7/28
 +
 33/2
 +
 +
 +
 +
 +
 +
9
 SP15
 –
 +
 –
 –
 –
 –
 –
 –
 –
SP32
 –
 +
 –
 –
 –
 –
 –
 –
 –
10
 SP6
 –
 –
 –
 –
 –
 –
 –
 –
 –
SP62
 –
 –
 –
 –
 –
 –
 –
 –
 –
SW73
 –
 –
 –
 –
 –
 –
 –
 –
 –
11
 SP67
 –
 +
 –
 –
 –
 –
 –
 –
 –
12
 SW76
 –
 +
 –
 –
 –
 –
 –
 –
 –
13
 ST123
 –
 +
 –
 –
 –
 –
 –
 –
 –
14
 PL57
 –
 +
 –
 –
 +
 +
 +
 +
 +
SW77
 –
 +
 –
 –
 +
 +
 +
 +
 +
15
 SP61
 –
 +
 –
 –
 –
 –
 –
 –
 –
16
 PL59
 –
 –
 –
 –
 –
 –
 –
 –
 –
17
 SP28
 –
 +
 –
 –
 –
 –
 –
 –
 –
18
 SP43
 –
 +
 –
 –
 –
 –
 –
 –
 –
19
 ST158
 –
 +
 –
 +
 +
 +
 +
 +
 +
SP13
 19/4
 14/10
 10/13
 +
 +
 +
 6/16
 +
 14/8
20 SP8 – + – – – – – – –

aThe results were determined by analysis of cloned sequences; + represents that nucleotide substitution at the variant site is detected and – represents that the nucleotide at the site is identical to the one of BJ01 reference sequence in all analyzed sequences.
bSARS, severe acute respiratory syndrome; SW, throat swab; PL, plasma; SP, sputum; ST, stool.
cThe numbers represent the ratio of reference to variant nucleotide detected at the site from the analyzed cloned sequences.

Main Article

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