Table 2

Genetic Variation of SARS Coronavirus in Beijing Hospital

Dongping Xu*, Zheng Zhang*, Fuliang Chu*, Yonggang Li*, Lei Jin*, Lingxia Zhang*, George F. Gao†, and Fu-Sheng Wang*

Author affiliations: *Beijing 302 Hospital, Beijing, China; †University of Oxford, Headington, Oxford, United Kingdom

Variation in S-gene sequences from 20 individual SARS patients^a,b

Pt. no.	Samp. no.	21494	21702	21858	22908	23198	24018	24247	24469	24540
Pt. no.	Samp. no.	C→T	A→G	A→T	A→G	T→C	A→T	T→C	A→G	A→G
1	SW6	–	–	–	–	–	–	–	–	–
2	SW17	9/2^c	+	–	–	–	–	+	–	–
3	PL1	8/39	8/43	48/2	+	+	+	+	+	+
4	PL10	14/7	+	–	+	+	2/8	+	+	+
	PL17	+	+	–	–	–	+	+	+	+
	SP4	–	+	–	+	–	+	+	+	+
5	PL9	+	+	–	+	+	+	+	+	+
	SP1	–	+	–	+	+	–	+	+	+
6	PL5	–	+	–	+	+	8/4	+	+	+
	SP9	–	+	–	+	+	+	+	+	+
7	PL7	–	+	–	+	+	4/6	+	+	+
8	PL8	7/28	+	33/2	+	+	+	+	+	+
9	SP15	–	+	–	–	–	–	–	–	–
	SP32	–	+	–	–	–	–	–	–	–
10	SP6	–	–	–	–	–	–	–	–	–
	SP62	–	–	–	–	–	–	–	–	–
	SW73	–	–	–	–	–	–	–	–	–
11	SP67	–	+	–	–	–	–	–	–	–
12	SW76	–	+	–	–	–	–	–	–	–
13	ST123	–	+	–	–	–	–	–	–	–
14	PL57	–	+	–	–	+	+	+	+	+
	SW77	–	+	–	–	+	+	+	+	+
15	SP61	–	+	–	–	–	–	–	–	–
16	PL59	–	–	–	–	–	–	–	–	–
17	SP28	–	+	–	–	–	–	–	–	–
18	SP43	–	+	–	–	–	–	–	–	–
19	ST158	–	+	–	+	+	+	+	+	+
	SP13	19/4	14/10	10/13	+	+	+	6/16	+	14/8
20	SP8	–	+	–	–	–	–	–	–	–

^aThe results were determined by analysis of cloned sequences; + represents that nucleotide substitution at the variant site is detected and – represents that the nucleotide at the site is identical to the one of BJ01 reference sequence in all analyzed sequences.
^bSARS, severe acute respiratory syndrome; SW, throat swab; PL, plasma; SP, sputum; ST, stool.
^cThe numbers represent the ratio of reference to variant nucleotide detected at the site from the analyzed cloned sequences.

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Volume 10, Number 5—May 2004

Research

Genetic Variation of SARS Coronavirus in Beijing Hospital

Table 2