Volume 13, Number 2—February 2007
Research
Community-associated Methicillin-resistant Staphylococcus aureus Isolates and Healthcare-Associated Infections1
Cynthia L. Maree*, Robert S. Daum†, Susan Boyle-Vavra†, Kelli Matayoshi‡2, and Loren G. Miller*‡
Table 1
Patients with healthcare-associated MRSA isolates, 1999–2004, and predictors of SCCmec type IV phenotype*
| Characteristic | Patients with HA-MRSA Isolates, % (no.) | SCCmec phenotype,% (no.) | Predictors of SCCmec type IV phenotype | ||||
|---|---|---|---|---|---|---|---|
| Bivariate anaylsis | Multivariate analysis | ||||||
| Type IV | Type II/III | Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | ||
| Total | (352) | 36 (128) | 64 (224) | ||||
| Sex | |||||||
| F | 35 (123) | 36 (44) | 64 (79) | 0.87 | >0.05 | ||
| M | 65 (229) | 37 (84) | 63 (145) | ||||
| Age, y | |||||||
| Mean | 50 ± 19 SD | 47±1.7 SE | 51±1.3 SE | 0.02 | >0.05 | ||
| Median (range) | 50 (<1–97) | 48 (<1–87) | 54 (<1–97) | ||||
| Time from admission to specimen collection, d | |||||||
| Mean | 19 ± 21 SD | 15±1.9 SE | 21±1.4 SE | 0.01 | 0.88 (0.8–0.98)† | 0.02 | |
| Median (range) | 12 (4–184) | 8 (4–174) | 15 (4–184) | ||||
| Culture specimen source | |||||||
| Blood | 10 (35) | 46 (16) | 54 (19) | 2.6 (1.2–5.7) | 0.02 | 2.2 (0.97–5.0) | 0.058 |
| Sputum | 34 (188) | 25 (29) | 75 (89) | Reference | Reference | ||
| Wound | 38 (133) | 49 (65) | 51 (68) | 2.9 (1.7–5.0) | <0.0001 | 2.6 (1.5–4.6) | 0.001 |
| Other | 19 (66) | 27 (18) | 73 (48) | 1.2 (0.6–2.3) | 0.69 | 1.1 (0.5–2.2) | 0.82 |
| Year culture specimen collected | |||||||
| 1999 | 52 (15) | 17 (9) | 83 (43) | Reference | <0.0001‡ | Reference | <0.0001 |
| 2000 | 57 (16) | 19 (11) | 81 (46) | 1.1 (0.4–3.0) | NS§ | ||
| 2001 | 65 (19) | 28 (18) | 72 (47) | 1.8 (0.7–4.5) | 1.8 (0.9–3.7) | ||
| 2002 | 47 (13) | 43 (20) | 57 (27) | 3.5 (1.4–8.9] | 3.2 (1.5–6.9) | ||
| 2003 | 63 (18) | 56 (35) | 44 (28) | 6.0 (2.4–14.3) | 5.2 (2.5–10.5) | ||
| 2004 | 68 (19) | 52 (35) | 48(33) | 5.1 (2.1–12) | 4.4 (2.2–8.8) | ||
*MRSA, methicillin-resistant Staphylococcus aureus; HA, healthcare associated; CI, confidence interval; SD, standard deviation; SE, standard error; NS, not significant; boldface indicates significance.
†Multivariate analysis results reflect time in weeks.
‡Measured with the Cochran-Armitage test of trends.
§Was not a significant predictor in the multivariate model.
1Findings from this investigation were presented in part at the 45th Annual International Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, USA, December 2005.
2Current affiliation: University of Southern California School of Pharmacy, Los Angeles, California
Page created: June 29, 2010
Page updated: June 29, 2010
Page reviewed: June 29, 2010
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