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Volume 14, Number 10—October 2008
Research

Endemic and Epidemic Lineages of Escherichia coli that Cause Urinary Tract Infections

Amee R. MangesComments to Author , Helen Tabor, Patricia Tellis, Caroline Vincent, and Pierre-Paul Tellier
Author affiliations: McGill University, Montréal, Québec, Canada (A.R. Manges, P. Tellis, C. Vincent, P.-P. Tellier); National Microbiology Laboratory, Winnipeg, Manitoba, Canada (H. Tabor);

Main Article

Table 2

Characteristics of clonal isolates of Escherichia coli from women with urinary tract infections, Montréal, Québec, Canada, 2006

Isolate no. Genotype* Serotype MLST† Phy‡ Date of infection Antimicrobial drug resistance profile§
CIP CEP NIT TMP-SMZ AMP CAM STR TET
362 C O1:H7 ST95 B2 2006 Jan 23 0 0 0 0 0 0 0 0
363 C O1:H7 2006 Jan 23 0 0 0 0 0 0 0 0
413 C O18:H7 ST95 B2 2006 Feb 13 0 0 0 0 0 0 0 0
414 C O1:H7 2006 Feb 13 0 0 0 0 0 0 0 0
439 C O1:H7 2006 Feb 28 0 0 0 0 0 0 0 0
762 C O1:K1:H7 ST95 B2 2006 Sep 28 0 0 0 0 0 0 0 0
767 C O1:K1:H7 2006 Sep 29 0 0 0 0 1 0 0 0
782 C O2:K1:H7 ST95 B2 2006 Oct 10 0 0 0 0 0 0 0 0
957 C O1:H7 2007 Jan 1 0 0 0 0 0 0 0 0
958 C O1:H7 ST95 B2 2007 Jan 5 0 0 0 0 0 0 0 0
412 H O6:H1 ST73 B2 2006 Feb 13 0 0 0 0 1 0 1 0
415 H O6:H1 2006 Feb 13 0 0 0 0 1 0 1 0
422 H O6:H1 2006 Feb 16 0 0 0 0 1 0 1 0
459 H O6:H1 2006 Mar 10 0 0 0 0 1 0 1 0
471 H O6:H1 2006 Mar 16 0 0 0 0 1 0 1 0
385 A OR:H18 ST69 D 2006 Jan 30 0 0 0 0 1 0 1 0
434 A O73:H18 ST69 D 2006 Feb 27 0 0 0 0 0 0 0 0
498 A O77/17:H18 ST69 D 2006 Mar 24 0 0 0 1 1 0 1 0
713 A OUNTYPE: HNM ST69 D 2006 Sep 11 0 0 0 1 1 0 1 0
724 A O15:H18 ST69 D 2006 Sep 13 0 0 0 0 0 0 0 0
799 A OUNTYPE: H18 ST69 D 2006 Oct 16 0 0 0 1 1 0 1 0
839 A O17:H18 ST69 D 2006 Nov 2 0 0 0 1 0 0 0 0
860 A O25:H18 ST69 D 2006 Nov 11 0 0 0 0 0 1 0 1
868 A OUNTYPE: H18 ST69 D 2006 Nov 15 0 0 0 0 0 0 0 0
908 A O17:H18 ST69 D 2006 Nov 30 0 0 0 1 1 0 0 1
912 A O17:H18 ST69 D 2006 Nov 30 0 0 0 1 1 0 1 0
913 A O17:HNM ST69 D 2006 Dec 1 0 0 0 0 0 0 0 1
956 A OUNTYPE: H18 ST69 D 2007 Jan 3 0 0 0 0 0 1 1 1
375 I O25:H4 ST131 B2 2006 Jan 25 1 0 0 0 1 0 0 0
452 I O25:H4 ST131 B2 2006 Mar 8 1 0 0 1 1 0 0 1
544 I O25:H4 2006 Apr 19 1 0 0 0 0 0 0 0
550 I O25:HNM ST131 B2 2006 Apr 20 1 0 0 1 1 0 1 1
760 I O25:H4 2006 Sep 28 1 0 0 1 1 0 0 1
783 I O25:H4 2006 Oct 11 1 0 0 0 1 0 0 0
841 I O25:H4 ST131 B2 2006 Nov 3 1 0 0 1 1 0 1 1

*Determined by ERIC2 PCR (24).
†MLST, multilocus sequence typing, according to Tartof et al. (27); ST, sequence type.
‡Phy, phylogenetic group, determined by multiplex PCR (28).
§0, sensitive; 1, resistant, according to Clinical and Laboratory Standards Institute interpretative criteria (23). CIP, ciprofloxacin; CEP, cephalothin; NIT, nitrofurantoin; TMP-SMZ, trimethoprim-sulfamethoxazole; AMP, ampicillin; CAM, chloramphenicol; STR, streptomycin; TET, tetracycline.

Main Article

References
  1. Russo  TA, Johnson  JR. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect. 2003;5:449–56. DOIPubMedGoogle Scholar
  2. Foxman  B, Geiger  AM, Palin  K, Gillespie  B, Koopman  JS. First-time urinary tract infection and sexual behavior. Epidemiology. 1995;6:162–8. DOIPubMedGoogle Scholar
  3. Remis  RS, Gurwith  MJ, Gurwith  D, Hargrett-Bean  NT, Layde  PM. Risk factors for urinary tract infection. Am J Epidemiol. 1987;126:685–94.PubMedGoogle Scholar
  4. Zhanel  GG, Karlowsky  JA, Harding  GK, Carrie  A, Mazzulli  T, Low  DE, A Canadian national surveillance study of urinary tract isolates from outpatients: comparison of the activities of trimethoprim-sulfamethoxazole, ampicillin, mecillinam, nitrofurantoin, and ciprofloxacin. Antimicrob Agents Chemother. 2000;44:1089–92. DOIPubMedGoogle Scholar
  5. Karlowsky  JA, Kelly  LJ, Thornsberry  C, Jones  ME, Sahm  DF. Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States. Antimicrob Agents Chemother. 2002;46:2540–5. DOIPubMedGoogle Scholar
  6. Phillips  I, Eykyn  S, King  A, Gransdsen  WR, Rowe  B, Frost  JA, Epidemic multiresistant Escherichia coli infection in West Lambeth Health District. Lancet. 1988;1:1038–41. DOIPubMedGoogle Scholar
  7. Johnson  JR, Stell  AL, O’Bryan  TT, Kuskowski  M, Nowicki  B, Johnson  C, Global molecular epidemiology of the O15:K52:H1 extraintestinal pathogenic Escherichia coli clonal group: evidence of distribution beyond. Eur J Clin Microbiol. 2002;40:1913–23. DOIGoogle Scholar
  8. Prats  G, Navarro  F, Mirelis  B, Dalmau  D, Margall  N, Coll  P, Escherichia coli serotype O15:K52:H1 as a uropathogenic clone. J Clin Microbiol. 2000;38:201–9.PubMedGoogle Scholar
  9. Olesen  B, Kolmos  HJ, Orskov  F, Orskov  I. Cluster of multiresistant Escherichia coli O78:H10 in Greater Copenhagen. Scand J Infect Dis. 1994;26:406–10. DOIPubMedGoogle Scholar
  10. Pitout  JD, Gregson  DB, Church  DL, Elsayed  S, Laupland  KB. Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase-producing Escherichia coli strains in the Calgary Health Region. J Clin Microbiol. 2005;43:2844–9. DOIPubMedGoogle Scholar
  11. Manges  AR, Johnson  JR, Foxman  B, O’Bryan  TT, Fullerton  KE, Riley  LW. Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group. N Engl J Med. 2001;345:1007–13. DOIPubMedGoogle Scholar
  12. Burman  WJ, Breese  PE, Murray  BE, Singh  KV, Batal  HA, MacKenzie  TD, Conventional and molecular epidemiology of trimethoprim-sulfamethoxazole resistance among urinary Escherichia coli isolates. Am J Med. 2003;115:358–64. DOIPubMedGoogle Scholar
  13. Johnson  JR, Manges  AR, O’Bryan  TT, Riley  LW. A disseminated multidrug-resistant clonal group of uropathogenic Escherichia coli in pyelonephritis. Lancet. 2002;359:2249–51. DOIPubMedGoogle Scholar
  14. Manges  AR, Natarajan  P, Solberg  OD, Dietrich  PS, Riley  LW. The changing prevalence of drug-resistant Escherichia coli clonal groups in a community: evidence for community outbreaks of urinary tract infections. Epidemiol Infect. 2006;134:425–31. DOIPubMedGoogle Scholar
  15. Coque  TM, Novais  A, Carattoli  A, Poirel  L, Pitout  J, Peixe  L, Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15. Emerg Infect Dis. 2008;14:195–200. DOIPubMedGoogle Scholar
  16. Woodford  N, Ward  ME, Kaufmann  ME, Turton  J, Egan  EJ, James  D, Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK. J Antimicrob Chemother. 2004;54:735–43. DOIPubMedGoogle Scholar
  17. Woodford  N, Kaufmann  ME, Karisik  E, Hartley  JW. Molecular epidemiology of multiresistant Escherichia coli isolates from community-onset urinary tract infections in Cornwall, England. J Antimicrob Chemother. 2007;59:106–9. DOIPubMedGoogle Scholar
  18. Health Protection Agency. Infections caused by ESBL-producing E. coli. London: The Agency. 2007 Sep 24 [cited 2008 Jul 16]. Available from http://www.hpa.org.uk/hpa/news/articles/press_releases/2007/070924_esbl.htm
  19. Johnson  JR, Kuskowski  MA, Smith  K, O’Bryan  TT, Tatini  S. Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods. J Infect Dis. 2005;191:1040–9. DOIPubMedGoogle Scholar
  20. Johnson  JR, Delavari  P, O'Bryan  TT, Smith  KE, Tatini  S. Contamination of retail foods, particularly turkey, from community markets (Minnesota, 1999–2000) with antimicrobial-resistant and extraintestinal pathogenic Escherichia coli. Foodborne Pathog Dis. 2005;2:38–49. DOIPubMedGoogle Scholar
  21. Schroeder  CM, White  DG, Ge  B, Zhang  Y, McDermott  PF, Ayers  S, Isolation of antimicrobial-resistant Escherichia coli from retail meats purchased in Greater Washington, DC, USA. Int J Food Microbiol. 2003;85:197–202. DOIPubMedGoogle Scholar
  22. York  MK, Baron  EJ, Clarridge  JE, Thompson  RB, Weinstein  MP. Multilaboratory validation of rapid spot tests for identification of Escherichia coli. J Clin Microbiol. 2000;38:3394–8.PubMedGoogle Scholar
  23. National Committee for Clinical. Laboratory Standards. Disk diffusion. Supplemental tables. Report no. NCCLS M100–S10. Wayne (PA): The Committee; 2000.
  24. Johnson  JR, O’Bryan  TT. Improved repetitive-element PCR fingerprinting for resolving pathogenic and nonpathogenic phylogenetic groups within Escherichia coli. Clin Diagn Lab Immunol. 2000;7:265–73. DOIPubMedGoogle Scholar
  25. Bender  JB, Hedberg  CW, Besser  JM, Boxrud  DJ, MacDonald  KL, Osterholm  MT. Surveillance for Escherichia coli O157:H7 infections in Minnesota by molecular subtyping. N Engl J Med. 1997;337:388–94. DOIPubMedGoogle Scholar
  26. Tenover  FC, Arbeit  RD, Goering  RV, Mickelsen  PA, Murray  BE, Persing  DH, Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33:2233–9.PubMedGoogle Scholar
  27. Tartof  SY, Solberg  OD, Manges  AR, Riley  LW. Analysis of a uropathogenic Escherichia coli clonal group by multilocus sequence typing. J Clin Microbiol. 2005;43:5860–4. DOIPubMedGoogle Scholar
  28. Clermont  O, Bonacorsi  S, Bingen  E. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl Environ Microbiol. 2000;66:4555–8. DOIPubMedGoogle Scholar
  29. Johnson  JR, Murray  AC, Kuskowski  MA, Schubert  S, Prere  MF, Picard  B, Distribution and characteristics of Escherichia coli clonal group A. Emerg Infect Dis. 2005;11:141–5.PubMedGoogle Scholar
  30. Nicolas-Chanoine  MH, Blanco  J, Leflon-Guibout  V, Demarty  R, Alonso  MP, Canica  MM, Intercontinental emergence of Escherichia coli clone O25:H4–ST131 producing CTX-M-15. J Antimicrob Chemother. 2008;61:273–81. DOIPubMedGoogle Scholar
  31. Manges  AR, Smith  SP, Lau  BJ, Nuval  CJ, Eisenberg  JN, Dietrich  PS, Retail meat consumption and the acquisition of antimicrobial resistant Escherichia coli causing urinary tract infections: a case-control study. Foodborne Pathog Dis. 2007;4:419–31. DOIPubMedGoogle Scholar
  32. Meacham  KJ, Zhang  L, Foxman  B, Bauer  RJ, Marrs  CF. Evaluation of genotyping large numbers of Escherichia coli isolates by enterobacterial repetitive intergenic consensus-PCR. J Clin Microbiol. 2003;41:5224–6. DOIPubMedGoogle Scholar
  33. Warren  RE, Doroshenko  A, Carr  R. Simultaneous bi-clonal outbreak of urinary infection with E. coli 025 with extended-spectrum β-lactamase CTX-M-15: community and hospital effects in two English Health Districts. Abstracts of the 14th European Congress of Clinical Microbiology and Infectious Diseases. Prague, Czech Republic. London: National Health Board; 2004. pp. 188–9.
  34. Manges  AR. Molecular epidemiology of acute, uncomplicated urinary tract infections in young women. Curr Infect Dis Rep. 2003;5:504–9. DOIPubMedGoogle Scholar
  35. Foxman  B, Zhang  L, Tallman  P, Andree  BC, Geiger  AM, Koopman  JS, Transmission of uropathogens between sex partners. J Infect Dis. 1997;175:989–92. DOIPubMedGoogle Scholar
  36. Johnson  JR, Brown  JJ, Carlino  UB, Russo  TA. Colonization with and acquisition of uropathogenic Escherichia coli as revealed by polymerase chain reaction-based detection. J Infect Dis. 1998;177:1120–4. DOIPubMedGoogle Scholar
  37. Johnson  JR, Clabots  C. Sharing of virulent Escherichia coli clones among household members of a woman with acute cystitis. Clin Infect Dis. 2006;43:e101–8. DOIPubMedGoogle Scholar
  38. Manges  AR, Johnson  JR, Riley  LW. Intestinal population dynamics of UTI-causing Escherichia coli within heterosexual couples. Curr Issues Intest Microbiol. 2004;5:49–57.PubMedGoogle Scholar
  39. Manges  AR, Dietrich  PS, Riley  LW. Multidrug-resistant Escherichia coli clonal groups causing community-acquired pyelonephritis. Clin Infect Dis. 2004;38:329–34. DOIPubMedGoogle Scholar
  40. Manges  AR, Perdreau-Remington  F, Solberg  O, Riley  LW. Multidrug-resistant Escherichia coli clonal groups causing community-acquired bloodstream infections. J Infect. 2006;53:25–9. DOIPubMedGoogle Scholar

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