Volume 14, Number 6—June 2008
Letter
Inquilinus limosus and Cystic Fibrosis
Fadi Bittar*, Anne Leydier†, Emmanuelle Bosdure†, Alexandre Toro*, Martine Reynaud-Gaubert‡, Stéphanie Boniface‡, Nathalie Stremler†, Jean-Christophe Dubus†, Jacques Sarles†, Didier Raoult*, and Jean-Marc Rolain*
Table
Clinical and epidemiologic features of cystic fibrosis (CF) patients with Inquilinus limosus*
| Case no. | Age, y/sex | Lung transplant | Positive samples | Clinical manifestation (first isolation) | Growth on MacConkey agar | Growth on selective agar (d) | Phenotypic identification† | Other associated pathogens | Reference |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 22/F | Yes | Lung explant, BAL, sputum | Pneumonia | Poor | ND | AR | PA, PM | (1) |
| 2 | 17/M | No | Sputum | Stable | No | Yes (6 d) | SP | SA, PA, CA | (3) |
| 3 | 14/F | No | Sputum | Stable | No | Yes (5 d) | SP | PA, AF, CA | (3) |
| 4 | 12/M | No | Sputum | Stable | ND | Yes (ND) | SP | PA, SM, SA, AX | (5) |
| 5 | 13/F | No | Sputum | Exacerbation | ND | Yes (ND) | SP | PA, SA, AF | (5) |
| 6 | 8/M | No | Sputum | Stable | ND | Yes (ND) | SP | PA | (5) |
| 7 | 10/M | No | Sputum | Stable | ND | Yes (ND) | SP | None | (5) |
| 8 | 18/M | No | Sputum | Exacerbation | ND | Yes (ND) | AR | PA, SA, AF | (5) |
| 9 | 16/F | No | Sputum | Severe exacerbation | ND | ND | PA | PA | (4) |
| 10 | 19/M | No | Sputum | Stable | ND | ND | ND | PA | (4) |
| 11 | 17/F | No | Sputum | Exacerbation | ND | ND | ND | PA, CA, AF | (4) |
| 12 | 20/F | No | Sputum | Exacerbation | ND | ND | ND | PA, SA, CA, AF | (4) |
| 13 | 17/F | No | Sputum | Stable | ND | ND | ND | PA, SA, SM, CA, AF | (4) |
| 14 | 35/M | No | Sputum | Respiratory decline | ND | ND | PA | PA, SM, SMA | (4) |
| 15 | 17/F | No | Sputum | Stable | No | Yes (4 d) | SP | CA | This study |
| 16 | 2/M | No | Sputum | Productive cough | No | Yes (3 d) | SP | SA, HI | This study |
| 17 | 21/M | No | Sputum | Exacerbation | No | Yes (3 d) | AR | PA, AF | This study |
| 18 | 15/M | No | Sputum | Fever and thoracic pain | No | Yes (3 d) | AR | SA | This study |
*BAL, bronchoalveolar lavage; ND, not determined; AR, Agrobacterium radiobacter; PA, Pseudomonas aeruginosa; PM, Proteus mirabilis; SP, Sphingomonas paucimobilis; SA, Staphylococcus aureus; CA, Candida albicans; AF, Aspergillus fumigatus; SM, Stenotrophomonas maltophilia; AX, Achromobacter xylosoxidans; SMA, Serratia marcescens; HI, Haemophilus influenzae.
†Phenotypic identification was obtained by using the BIOLOG GN MicroPlate assay (BIOLOG Inc., Hayward, CA, USA) for case 1 and the API 20NE kit system (bioMérieux, Marcy l’Etoile, France) for cases 2–8 and 15–18.
References
- Pitulle C, Citron DM, Bochner B, Barbers R, Appleman MD. Novel bacterium isolated from a lung transplant patient with cystic fibrosis. J Clin Microbiol. 1999;37:3851–5.PubMedGoogle Scholar
- Coenye T, Goris J, Spilker T, Vandamme P, Lipuma JJ. Characterization of unusual bacteria isolated from respiratory secretions of cystic fibrosis patients and description of Inquilinus limosus gen. nov., sp. nov. J Clin Microbiol. 2002;40:2062–9. DOIPubMedGoogle Scholar
- Wellinghausen N, Essig A, Sommerburg O. Inquilinus limosus in patients with cystic fibrosis, Germany. Emerg Infect Dis. 2005;11:457–9.PubMedGoogle Scholar
- Schmoldt S, Latzin P, Heesemann J, Griese M, Imhof A, Hogardt M. Clonal analysis of Inquilinus limosus isolates from six cystic fibrosis patients and specific serum antibody response. J Med Microbiol. 2006;55:1425–33. DOIPubMedGoogle Scholar
- Chiron R, Marchandin H, Counil F, Jumas-Bilak E, Freydiere AM, Bellon G, Clinical and microbiological features of Inquilinus sp. isolates from five patients with cystic fibrosis. J Clin Microbiol. 2005;43:3938–43. DOIPubMedGoogle Scholar
- Cooke RP, O’Neill WA, Xu J, Moore JE, Elborn JS. Inquilinus limosus isolated from a cystic fibrosis patient: first UK report. Br J Biomed Sci. 2007;64:127–9.PubMedGoogle Scholar
- Kiratisin P, Koomanachai P, Kowwigkai P, Pattanachaiwit S, Aswapokee N, Leelaporn A. Early-onset prosthetic valve endocarditis caused by Inquilinus sp. Diagn Microbiol Infect Dis. 2006;56:317–20. Epub 2006 Jul 18. DOIPubMedGoogle Scholar
- Rivarola V, Castro S, Mori G, Jofre E, Fabra A, Garnica R, Response of Azospirillum brasilense Cd to sodium chloride stress. Antonie Van Leeuwenhoek. 1998;73:255–61. DOIPubMedGoogle Scholar
- Suzuki T, Muroga Y, Takahama M, Nishimura Y. Roseivivax halodurans gen. nov., sp. nov. and Roseivivax halotolerans sp. nov., aerobic bacteriochlorophyll-containing bacteria isolated from a saline lake. Int J Syst Bacteriol. 1999;49:629–34.PubMedGoogle Scholar
- Herasimenka Y, Cescutti P, Impallomeni G, Rizzo R. Exopolysaccharides produced by Inquilinus limosus, a new pathogen of cystic fibrosis patients: novel structures with usual components. Carbohydr Res. 2007;342:2404–15. DOIPubMedGoogle Scholar
Page created: July 09, 2010
Page updated: July 09, 2010
Page reviewed: July 09, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.