Volume 16, Number 7—July 2010
Dispatch
Vaccine-associated Paralytic Poliomyelitis in Immunodeficient Children, Iran, 1995–2008
Table 2
Underlying primary immunodeficiency and immunologic findings for patients with vaccine-associated paralytic poliomyelitis, Iran, 1995–2008*
Patient no. | Underlying immunodeficiency | Leukocytes, cells/μL | ALC, cells/μL | CD3,† cells/μL | CD4,† cells/μL | CD8,† cells/μL | CD19,† cells/μL | IgG,‡ mg/dL | IgM,‡ mg/dL | IgA,‡ mg/dL |
---|---|---|---|---|---|---|---|---|---|---|
1 | Undefined hypogammaglobulinemia | NA | NA | NA | NA | NA | NA | NA | NA | NA |
2 | MHC class II deficiency | 6,300 | 3,642 | 1,216 | 608 | 607 | 1,460 | 200 | <10 | <10 |
3 | SCID | 1,700 | 731 | 138 | 96 | 32 | 10 | 45 | <10 | <10 |
4 | XLA | 6,500 | 3,375 | 2,700 | 1,404 | 1,290 | 35 | 556 | <10 | <10 |
5 | SCID | 6,800 | 2,589 | 336 | 184 | 185 | 160 | <10 | <10 | <10 |
6 | XLA | 8,500 | 4,000 | 2,760 | 1,920 | 835 | 40 | 20 | 58 | 25 |
*ALC, absolute lymphocyte count; Ig, immunoglobulin; NA, not available; MHC, major histocompatibility complex; SCID, severe combined immunodeficiency; XLA, X-linked agammaglobulinemia.
†Reference ranges for lymphocyte subpopulations: CD3, 1,900–5,900; CD4, 1,400–4,300; CD8, 500–1,700; CD19, 610–2,600 cells/μL.
‡Reference ranges for immunoglobulins: IgG, 661 ± 219; IgM, 54 ± 23; IgA, 37 ± 18.