Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues
Yoshifumi Iwamaru
, Morikazu Imamura, Yuichi Matsuura, Kentaro Masujin, Yoshihisa Shimizu, Yujing Shu, Megumi Kurachi, Kazuo Kasai, Yuichi Murayama, Shigeo Fukuda, Sadao Onoe, Ken’ichi Hagiwara, Yoshio Yamakawa, Tetsutaro Sata, Shirou Mohri, Hiroyuki Okada, and Takashi Yokoyama
Author affiliations: National Institute of Animal Health, Tsukuba, Ibaraki, Japan (Y. Iwamaru, M. Imamura, Y. Matsuura, K. Masujin, Y. Shimizu, Y. Shu, M. Kurachi, K. Kasai, Y. Murayama, S. Mohri, H. Okada, T. Yokoyama); Hokkaido Animal Research Center, Hokkaido, Japan (S. Fukuda, S. Onoe); National Institute of Infectious Diseases, Tokyo, Japan (K. Hagiwara, Y. Yamakawa, T. Sata)
Main Article
Figure 2
Figure 2. Bioassay using nerve tissues obtained from bovine spongiform encephalopathy JP24 prion-inoculated cattle. Inocula from selected tissues—obex (A), sciatic nerve (B), adrenal gland (C), branchial nerve plexus (D), and vagus nerve cervical part (E)—were prepared from cattle euthanized at 10 (code 8515, circle), 12 (code 498, square), and 16 (code 5566, triangle) months postinoculation were and inoculated intracerebrally into mice transgenic for bovine prion protein. Ratios above graph indicate number of prion-diseased mice/number of inoculated mice at 500 d postinoculation.
Main Article
Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.