Volume 16, Number 8—August 2010
CME ACTIVITY - Research
Correlation of Pandemic (H1N1) 2009 Viral Load with Disease Severity and Prolonged Viral Shedding in Children
Chung-Chen Li1, Lin Wang1, Hock-Liew Eng1, Huey-Ling You, Ling-Sai Chang, Kuo-Shu Tang, Ying-Jui Lin, Hsuan-Chang Kuo, Ing-Kit Lee, Jien-Wei Liu, Eng-Yen Huang, and Kuender D. Yang
Table 2
Factors associated with duration of viral shedding in 60 patients with pandemic (H1N1) 2009 virus infection, Taiwan*
| Variable | Viral RNA detected 7 d after symptom onset, % | p value (UVA) | HR (95% CI) | p value (MVA) |
|---|---|---|---|---|
| Age (<13 vs. >13 y) | 88.7 vs. 38.1 | <0.001 | 4.99 (2.34–10.66) | <0.001 |
| Sex (M vs. F) | 59.6 vs. 71.5 | 0.650 | 1.18 (0.57–2.44) | 0.658 |
| Disease severity (mild vs. severe)† | 60.8 vs. 77.9 | 0.247 | 1.38 (0.56–3.45) | 0.487 |
| Time to initiate antiviral treatment (<48 h vs. >48 h) | 60.6 vs. 81.8 | 0.176 | 2.56 (0.88–7.69) | 0.085 |
| Viral load from the first throat swab (<4.35 vs. >4.35 log10 copies/mL) | 64.7 vs. 55.8 | 0.745 | 1.68 (0.64–4.37 | 0.292 |
| Coexisting conditions (no vs. yes) | 70.7 vs. 45.5 | 0.402 | 1.85 (0.78–4.39) | 0.137 |
*UVA, univariate analysis; MVA, multivariate analysis; HR, hazard ratio; CI, confidence interval.
†Severe illness included pneumonia and meningoencephalitis; mild illness included upper respiratory tract infection and bronchitis.
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