Volume 4, Number 2—June 1998
Synopsis
Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome
Table 2
Susceptibility of Campylobacter jejuni strains to killing by normal human serum (NHS)
| Illness | O serotype | No. of strains studied | No. (%) with
>1 log killa, |
Median log kill (interquartile range) |
||
|---|---|---|---|---|---|---|
| Pool 1c | Pool 2c | Pool 1 | Pool 2 | |||
| GBSd | 19 | 7 | 1 (14) | 0 (0) | 0.53 (0.18-0.63) | 0.39 (0.08-0.52) |
| Enteritis | 19 | 11 | 0 (0) | 0 (0) | 0.37 (0.09-0.47) | 0.48 (0.29-0.50) |
| GBS | non-19 | 10 | 3 (30) | 3 (30) | 0.70 (0.44-1.18) | 0.43 (0.03-1.32) |
| Enteritis | non-19 | 16 | 8 (50) | 7 (44) | 0.90 (0.24-2.00) | 0.59 (0.35-2.53) |
| All | 19 | 18 | 1 (6) | 0 (0) | 0.38 (0.17-0.58) | 0.45 (0.23-0.52) |
| All | non-19 | 26 | 11 (42) | 10 (38) | 0.70 (0.26-1.86) | 0.54 (0.17-2.27) |
aBacterial suspensions were incubated in either NHS or heat inactivated NHS at 37°C for 1 hr as described in text, and net CFU (NHS minus HINHS) determined. Values greater than 1 log10 kill were considered to denote a serum-susceptible strain.
bComparison of O:19 strains with non-O:19 strains: Pool 1, odds ratio = 12.5, p = 0.008; Pool 2, odds ratio = undefined, p = 0.003.
cPool 1 consists of C. jejuni-antibody positive serum from five healthy adults; Pool 2 consists of C. jejuni-antibody negative serum from two healthy adults.
dGBS = Guillain-Barré syndrome.
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