Volume 7, Number 1—February 2001
Research
Persistence and variability of Stenotrophomonas maltophilia in Cystic Fibrosis Patients, Madrid, 1991-1998
Sylvia Valdezate*†, Ana Vindel†, Luis Maiz*, Fernando Baquero*, Hector Escobar*, and Rafael Cantón*
Table
Demographic characteristics and co-colonization status of cystic fibrosis patients with Stenotrophomonas maltophilia infection or colonization
| Characteristics | SM-SEa (14 patients) | SM-REb (11 patients) |
|---|---|---|
| Gender | ||
| Male | 8 | 5 |
| Female | 6 | 6 |
| Patient genotyped | 11 | 9 |
| Homozygous F508 | 8 | 3 |
| Heterozygous F508 | 3 | 5 |
| Other | 0 | 1 |
| Mean age at first S. maltophilia isolation (SD, years) | 13.4 (7.3) | 16.7 (7.4) |
| FEV1 measured | 11 | 10 |
| FEV1 (% predicted) before S. maltophilia recovery (Mean [SD]) | 68.7 (29.6) | 74.2 (28.3) |
| >100 | 2 | 1 |
| 70-99 | 3 | 5 |
| 40-69 | 4 | 3 |
| < 40 | 2 | 1 |
| FEV1 (% predicted) after S. maltophilia recovery (Mean [SD]) | 63.8 (20.7) | 62.9 (24.2) |
| ABPAc condition | 2 | 1 |
| Death (%) | 4 (28.5) | 2 (18.2) |
| S. maltophilia bacterial counts (geometric mean, cfu/mL) | 8.4 x 104 d | 2.9 x 108 d |
| Pseudomonas aeruginosa detected (%) | 12 (85.7) | 9 (81.8) |
| Aspergillus detected (%) | 7 (50.0) | 7 (63.6) |
| S. maltophilia co-colonization with:e | ||
| Only S. maltophilia detected (%) | 1 (7.1) | 1 (9.1) |
| P. aeruginosa (%) | 8 (57.1) | 3 (27.2) |
| Staphylococcus aureus (%) | 6 (42.8) | 3 (27.2) |
| Burkholderia cepacia (%) | 1 (7.1) | 1 (9.1) |
| Aspergillus spp. (%) | 1 (7.1) | 3 (27.2) |
| Candida (%) | 3 (21.4) | 2 (18.2) |
aSM-SE = CF patients with a single episode of S. maltophilia colonization.
bSM-RE: CF patients with repeated episodes of S. maltophilia colonization.
cABPA: allergic bronchopulmonary aspergillosis.
dp<0.05 comparing both groups.
ePatients in the SM-RE group colonized with organisms in addition to S. maltophilia. When different cocolonizations occurred in the same patient, we recorded only the co-colonization that was at least twice as frequent.
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