Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping
Tuberculosis Genotyping Network, United States
Use of DNA Fingerprinting To Investigate a Multiyear, Multistate Tuberculosis Outbreak
Peter D. McElroy*
, Timothy R. Sterling†, Cynthia R. Driver‡, Barry N. Kreiswirth§, Charles L. Woodley*, Wendy A. Cronin¶, Darryl X. Hardge*†, Kenneth L. Shilkret#, and Renee Ridzon1*
, Timothy R. Sterling†, Cynthia R. Driver‡, Barry N. Kreiswirth§, Charles L. Woodley*, Wendy A. Cronin¶, Darryl X. Hardge*†, Kenneth L. Shilkret#, and Renee Ridzon1*
Table 1
Clinical characteristics of tuberculosis outbreak patients, New Jersey, New York City, Baltimore, and Maryland, 1995–2001
| Characteristic | New Jersey n=5 | New York City n=10 | Baltimore n=18 | Maryland n=6 | Total n=39 (%) |
|---|---|---|---|---|---|
| Culture-positive | 4 | 10 | 17 | 5 | 36 (92) |
| Sputum smear–positive | 1 | 4 | 9 | 3 | 17 (44) |
| Disease site | |||||
| Pulmonary only | 2 | 5 | 11 | 4 | 22 (56) |
| Exrapulmonary only | 0 | 2 | 4 | 2 | 8 (21) |
| Pulmonary-extrapulmonary | 3 | 3 | 3 | 0 | 9 (23) |
| Cavitary disease | 0 | 0 | 2 | 1 | 3 (8) |
| HIV status | |||||
| Positive | 2 | 7 | 11 | 1 | 21 (54) |
| Unknown | 1 | 0 | 1 | 1 | 3 (8) |
| Deceaseda | 2 | 2 | 1 | 1 | 6 (15) |
aFour of six patients died within 3 months of their TB diagnosis.
1 PDM, TRS, CRD, BK, CLW, WAC, DXH, KLS, and RR were involved in the conception and design of various phases (epidemiologic and laboratory methods) of this investigation. All coauthors were responsible for collection of either epidemiologic or molecular genotyping data. Analysis and interpretation of the data were primarily performed by PDM, TRS, and RR. All coauthors participated in preparation and critical review of the manuscript.
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