Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping
Tuberculosis Genotyping Network, United States
Molecular Typing of Mycobacterium tuberculosis Strains with a Common Two-Band IS6110 Pattern
Kerry H. Lok*, William H. Benjamin*, Michael E. Kimerling*
, Virginia Pruitt†, Donna Mulcahy†, Nancy Robinson†, Nancy B. Keenan†, and Nancy E. Dunlap*
, Virginia Pruitt†, Donna Mulcahy†, Nancy Robinson†, Nancy B. Keenan†, and Nancy E. Dunlap*
Table
Comparison of a common two-band IS6110 RFLP pattern with spoligotyping and VNTRa
| Spoligotyping | VNTR | Related to conventional outbreak | ||||
|---|---|---|---|---|---|---|
| Octal (CDC designation) |
No. of isolates |
VNTR results
(AL designation) |
No. of isolates |
Store |
Bus |
Homeless |
| 777776777760601(0009) | 55 | 6,3,2,4,2,3,2 (01) | 22 | 2 | ||
| 6,3,2,3,2,2,2 (02) | 12 | 4 | 4 | |||
| 6,3,2,4,2,3,3 (03) | 8 | 2 | ||||
| 6,3,2,3,2,2,3 (04) | 4 | 3 | ||||
| 6,3,2,2,2,2,2 (05) | 3 | 3 | ||||
| 6,3,2,3,2,3,2 (06) | 2 | |||||
| 6,3,2,3,2,3,3 (07) | 2 | 1 | ||||
| 6,3,2,4,2,2,2 (08) | 1 | |||||
| 6,2,2,3,2,2,2 (09) | 1 | 1 | ||||
| 037776777760601(0545) | 14 | 6,3,2,3,2,4,2 (10) | 14 | 14 | ||
| 777776777760771(0003) | 12 | 6,3,2,2,2,1,2 (11) | 7 | 5 | ||
| 6,3,2,3,2,3,2.5 (12) | 1 | |||||
| 6,3,2,2,2,1,3 (13) | 1 | |||||
| 6,3,1,2,2,2,3 (14) | 1 | 1 | ||||
| 6,3,2,3,2,2,2 (02) | 1 | 1 | ||||
| 6,3,2,3,2,3,3 (07) | 1 | |||||
| 001776777760601(0550) | 3 | 6,3,2,4,2,3,2 (01) | 3 | |||
| 777776374360711(1445) | 1 | 6,3,2,1,2,3,2.5 (15) | 1 | 1 | ||
| 037766677760601(n/a) | 1 | 6,3,2,3,2,4,2 (10) | 1 | 1 | ||
| Total | 86 | 86 | 15 | 4 | 24 | |
aRFLP, restriction fragment length polymorphism; VNTR, variable number of tandem repeats, CDC, Centers for Disease Control and Prevention.
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