Volume 8, Number 8—August 2002
Research
Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-Resistant Enterococcus
Yehuda Carmeli*†
, George M. Eliopoulos*†, and Matthew H. Samore*†
, George M. Eliopoulos*†, and Matthew H. Samore*†
Table 1
Patient characteristics and matched univariate analysis for isolation of nosocomial vancomycin-resistant enterococci
| Variable | Cases (%) (233) | Control (%) (647) | Odds ratio | p value |
|---|---|---|---|---|
| Agea | 61.7 | 62.3 | .999 | 0.76 |
| Gender (female) | 114 (49) | 292 (45) | 1.2 | 0.34 |
| Main admitting diagnosis | ||||
| Orthopedic condition | 5 (6.4) | 53 (8.2) | R | R |
| Cardiovascular condition | 49 (21) | 236 (36) | 0.37 | <0.001 |
| Endocrine disorder | 6 (2.6) | 13 (2) | 1.3 | 0.6 |
| Gastrointestinal disorder | 77 (33) | 160 (25) | 1.7 | 0.005 |
| Genitourinary disorder | 18 (7.7) | 35 (5.4) | 1.4 | 0.21 |
| Infectious disease | 26 (11) | 19 (3) | 3.7 | <0.001 |
| Hematologic disease | 5 (2.1) | 12 (1.9) | 0.83 | 0.7 |
| Neurologic disease | 18 (7.7) | 69 (10.7) | 0.72 | 0.3 |
| Pulmonary disease | 19 (8.1) | 49 (7.6) | 1.1 | 0.8 |
| Coexisting conditions | ||||
| Cardiovascular disease | 160 (69) | 460 (71) | 0.85 | 0.36 |
| Lung disease | 32 (14) | 88 (14) | 1 | 0.95 |
| Diabetes mellitus | 127 (55) | 262 (40) | 1.9 | <0.001 |
| Organ transplant recipient | 39 (17) | 45 (7) | 2.9 | <0.001 |
| Renal disease | 57 (24) | 103 (16) | 1.6 | 0.013 |
| Cancer | 25 (11) | 93 (14) | .71 | 0.18 |
| AIDS | 2 (1) | 8 (1) | .75 | 0.7 |
| Hepatobiliary disease | 65 (28) | 97 (15) | 2.5 | <0.001 |
| Charlson comorbidity scorea | 3.2 | 2.7 | 1.114 | 0.003 |
| Transfer from an institution | 84 (36) | 243 (37) | 0.9 | 0.56 |
| Surgery | 67 (29) | 211 (33) | 0.55 | 0.01 |
| Admission to ICU | 65 (28) | 169 (26) | .78 | 0.38 |
| MRSA | ||||
| During current admission | 18 (8) | 16 (2.5) | 3.9 | 0.001 |
| In past year | 28 (12) | 26 (4) | 3.5 | <0.001 |
| Clostridium difficile | ||||
| During current admission | 5 (2.1) | 10 (1.5) | 1.3 | 0.59 |
| In past year | 17 (7.3) | 20 (3.1) | 2.6 | 0.006 |
aContinuous variable.
R, reference group; MRSA, methicillin-resistant Staphylococcus aureus.
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