Volume 8, Number 9—September 2002
Research
Molecular Characterization of Campylobacter jejuni Clones: A Basis for Epidemiologic Investigation
Kate E. Dingle*, Frances M. Colles*, Roisin Ure, Jaap A. Wagenaar‡, Birgitta Duim‡, Frederick J. Bolton, Andrew J. Fox§, David R.A. Wareing, and Martin C.J. Maiden*
Table 2
Clonal complexes of Campylobacter jejuni isolates
| Clonal complex | Isolates (n) | STa of central genotype |
No. of STs | No. of cell-surface component variants |
Cell-surface component variants (p<0.001) c |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| aspA | glnA | gltA | glyA | pgm | tkt | uncA | HS serotypesb | FlaA SVR | Antigen combinations | HS serotypes | FlaA SVR | |||
| ST-21 | 271 | 2 | 1 | 1 | 3 | 2 | 1 | 5 | 98 | 11 | 8 | 24 | 1,2,4c,8,10 | 1,10 |
| ST-45 | 93 | 4 | 7 | 10 | 4 | 1 | 7 | 1 | 48 | 31 | 17 | 44 | 6, 7, 9, 12, 15, 21, 27, 33, 38, 42, 45, 55, 57, 60 | 1, 2, 5, 8, 9, 12, 18, 27 |
| ST-206 | 60 | 2 | 21 | 5 | 37 | 2 | 1 | 5 | 37 | 3 | 8 | 9 | 1,4c | 1,11 |
| ST-61 | 57 | 1 | 4 | 2 | 2 | 6 | 3 | 17 | 19 | 2 | 9 | 5 | 4c | 6,13,14 |
| ST-48 | 54 | 2 | 4 | 1 | 2 | 7 | 1 | 5 | 22 | 4 | 5 | 7 | 4c | 1,4 |
| ST-257 | 46 | 9 | 2 | 4 | 62 | 4 | 5 | 6 | 21 | 4 | 3 | 4 | 11 | 12 |
| ST-353 | 29 | 7 | 17 | 5 | 2 | 10 | 3 | 6 | 24 | 9 | 8 | 14 | 3,11,37 | 2,11 |
| ST-42 | 22 | 1 | 2 | 3 | 4 | 5 | 9 | 3 | 7 | 5 | 4 | 5 | 23,36,23/36 | 9 |
| ST-403 | 20 | 10 | 27 | 16 | 19 | 10 | 5 | 7 | 12 | 5 | 6 | 7 | 35 | 35 |
| ST-52 | 18 | 9 | 25 | 2 | 10 | 22 | 3 | 6 | 11 | 7 | 3 | 7 | 5,11 | 4 |
| ST-177 | 17 | 17 | 2 | 8 | 5 | 8 | 2 | 4 | 17 | 5 | 13 | 7 | - | - |
| ST-354 | 13 | 8 | 10 | 2 | 2 | 11 | 12 | 6 | 4 | 5 | 7 | 8 | 53 | 1,20,33 |
| ST-22 | 12 | 1 | 3 | 6 | 4 | 3 | 3 | 3 | 5 | 2 | 3 | 3 | 19 | 3 |
| ST-433 | 11 | 2 | 59 | 4 | 38 | 17 | 12 | 35 | 11 | 6 | 3 | 9 | 1,53 | - |
| ST-362 | 9 | 1 | 2 | 49 | 4 | 11 | 66 | 8 | 1 | 1 | 1 | 1 | 41 | 3 |
| ST-179 | 10 | 1 | 6 | 7 | 2 | 40 | 32 | 3 | 9 | 2 | 2 | 3 | - | - |
| ST-49 | 6 | 3 | 1 | 5 | 17 | 11 | 11 | 6 | 2 | 2 | 2 | 2 | 18 | 11 |
aST, sequence type; HS, heat stable; SVR, short variable region; -, no antigen variants were associated that were statistically significant (p>0.001), but isolates were antigenically varied.
bHS 4 complex serotypes (4c) were counted as one serotype.
cAntigen variants that were significantly associated with a particular clonal complex by the chi-square test. Isolates containing other antigen variants were also found in each complex, as were isolates which were nontypable by HS serotyping.
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