Volume 9, Number 6—June 2003
Research
Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong
J.S. Malik Peiris*, Wing-Hong Tang*, Kwok-Hung Chan*, Pek-Lan Khong*, Yi Guan*, Yu-Lung Lau*, and Susan S. Chiu*
Table 2
Characteristics of 32 children admitted with HMPV compared with age-matched controls with RSV and influenza Aa
| Characteristics | HMPV |
RSV |
Influenza A |
p valueb |
||
|---|---|---|---|---|---|---|
| No. positive/ total (%) | No. positive/ total (%) | No. positive/ total (%) | Overall | HMPV vs. RSV | HMPV vs. influenza A | |
| Influenzalike illness in family contact |
10/19 (52.6) |
7/29 (24.1) |
19/24 (79.1) |
0.0003 |
0.29 |
0.37 |
| Influenzalike illness in adult family contact |
5/19 (26.3) |
4/29 (13.8) |
13/24 (54.2) |
0.005 |
0.68 |
0.45 |
| Febrile seizures |
5/32 (15.6) |
1/32 (3.1) |
3/32 (9.4) |
0.229 |
— |
— |
| Congested pharynx |
12/32 (37.5) |
11/32 (34.4) |
11/32 (34.4) |
0.955 |
— |
— |
| Rash |
4/32 (12.5) |
1/32 (3.1) |
4/32 (12.5) |
0.331 |
— |
— |
| Enlarged liver |
2/32 (6.3) |
0/32 (0.0) |
4/32 (12.5) |
0.331 |
— |
— |
| Otitis media |
4/32 (12.5) |
0/32 (0.0) |
0/32 (0.0) |
0.201 |
— |
— |
| Diarrhea |
2/32 (6.3) |
1/32 (3.1) |
3/32 (9.4) |
0.586 |
— |
— |
| Crepitations |
18/32 (56.3) |
14/32 (43.8) |
3/32 (9.4) |
0.0003 |
0.50 |
0.0007 |
| Wheezing |
9/32 (28.1) |
12/32 (37.5) |
2/32 (6.3) |
0.0109 |
0.60 |
0.04 |
| Asthma exacerbation |
6/32 (18.8) |
2/32 (6.3) |
2/32 (6.3) |
0.167 |
— |
— |
| Acute bronchiolitis |
3/32 (9.4) |
10/32 (31.3) |
0/32 (0.0) |
0.0009 |
0.13 |
0.37 |
| Pneumonia |
12/32 (37.5) |
5/32 (15.6) |
1/32 (3.1) |
0.0017 |
0.30 |
0.009 |
| Abnormal chest x-ray |
17/25 (68.0) |
11/18 (61.1) |
1/17 (5.9) |
0.0002 |
0.89 |
0.0002 |
| Lymphopenia (<1.5 x 109/L) |
9/31 (29.0) |
2/27 (7.4) |
12/29 (41.4) |
0.017 |
0.34 |
1.0 |
| Neutropenia (ANC<1 x 109/L) |
2/31 (6.5) |
0/27 (0.0) |
4/29 (13.8) |
0.125 |
— |
— |
| Elevated transaminases | 2/15 (13.3) | 0/5 (0.0) | 3/11 (27.3) | 0.357 | — | — |
aHMPV, human metapneumovirus; RSV, respiratory syncytial virus.
bp values performed using McNemar chi-square test.
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