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Volume 9, Number 6—June 2003
Research

Histopathologic Features of Mycobacterium ulcerans Infection

Jeannette Guarner*Comments to Author , Jeanine Bartlett*, Ellen A. Spotts Whitney*, Pratima L. Raghunathan*, Ymkje Stienstra†, Kwame Asamoa‡, Samuel Etuaful§, Erasmus Klutse¶, Eric Quarshie#, Tjip S. van der Werf†, Winette T.A. van der Graaf†, C. Harold King**, and David A. Ashford*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Groningen University Hospital, the Netherlands; ‡Ministry of Health, Accra, Ghana; §St. Martins Catholic Hospital, Agroyesum, Ghana; ¶Dunkwa Government Hospital, Dunkwa, Ghana; #Presbyterian Hospital, Agogo, Ghana; **Emory University, Atlanta, Georgia, USA

Main Article

Table 4

Comparison of histopathologic features of preulcerative and ulcerative lesions in definite Buruli ulcer cases

Histopathologic feature Preulcerative no. (%) Ulcerative no. (%) p value
Epidermis
 8 (42)
 42 (78)
 0.005
Hyperplasiaa
Dermis
 17 (85)
 28(52)
 0.015
Elastolysisa
AFB in dermisb
 8 (40)
 10 (19)
 0.34
Subcutaneous tissue
AFB in subcutisc
 18 (78)
 31 (56)
 0.074
Acute inflammationd
 22 (96)
 50 (91)
 0.48
Chronic inflammatione
 4 (17)
 27 (49)
 0.013
Granulomasf 3 (13) 27 (49) 0.005

aTwo specimens did not have epidermis, and one did not have dermis.
bConsidered as presence of acid-fast bacili (AFB) in dermis.
cConsidered as intense versus mild AFB in subcutis.
dAcute inflammation considered as present versus absent.
eChronic inflammation considered as intense versus mild.
fGranulomas considered as present versus absent.

Main Article

Page created: December 21, 2010
Page updated: December 21, 2010
Page reviewed: December 21, 2010
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