Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 10, Number 9—September 2004
Research

Viral Loads in Clinical Specimens and SARS Manifestations

I.F.N. Hung*, V.C.C. Cheng*, A.K.L. Wu†, B.S.F. Tang*, K.H. Chan*, C.M. Chu‡, M.M.L. Wong§, W.T. Hui*, L.L.M. Poon*, D.M.W. Tse§, K.S. Chan‡, P.C.Y. Woo*, S.K.P. Lau*, J.S.M. Peiris*, and K.Y. Yuen*Comments to Author 
Author affiliations: *Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region (SAR), People’s Republic of China; †Prince of Wales Hospital, Hong Kong SAR, People’s Republic of China; ‡United Christian Hospital, Hong Kong SAR, People’s Republic of China; §Caritas Medical Centre, Hong Kong SAR, People’s Republic of China

Main Article

Table 3

Correlation of RT-qPCR of clinical specimens taken during days 10 to 15, and clinical manifestations in 154 patients with SARSa

Specimen Diarrhea
 O2 desaturation
 Mechanical ventilation
 Death
Y N p value; OR 
(CI) Y N p value; OR (CI) Y N p value; OR (CI) Y N p value; OR 
(CI)
NPA (n = 142)
  RT-qPCR (+) (n = 60) 37 23 < 0.01; 2.5 
(1.3–5.0) 37 23 < 0.01; 3.1 (1.6–6.2) 22 38 < 0.01; 11.3 (3.6–35.1) 24 36 < 0.01; 54 
(7.1–415.0)
  RT-qPCR (–) (n = 82) 32 50 28 54 4 78 1 81
  Median viral load (log10 copies/mL) 3.2 0 0.02 4.5 0 < 0.01 6.4 0 < 0.01 6.5 0 < 0.01
Serum (n = 53)
  RT-qPCR (+) (n = 22) 12 10 0.4 13 9 < 0.01; 5 
(1.5–16.4) 7 15 < 0.01; 1.5 
(1.1–2.0) 8 14 < 0.01; 17.1 (2.0–151.0)
  RT-qPCR (–) (n = 31) 13 18 7 24 0 31 0 31
  Median viral load 
(log10 copies/mL) 0 0 0.5 2.3 0 < 0.01 2.6 0 < 0.01 2.6 0 < 0.01
Stool (n = 94)
  RT-qPCR (+) (n = 82) 46 36 < 0.01; 14.1 (1.7–114.0) 39 43 0.5 16 66 1 17 65 0.5
  RT-qPCR (–) (n = 12) 1 11 4 8 2 10 1 11
  Median viral load 
(log10 copies/mL) 7.5 5 < 0.01 7.2 5 0.1 8 7 0.05 8.3 6.9 < 0.01
Urine (n = 111)
  RT-qPCR (+) (n = 32) 23 9 < 0.01; 3.8 
(1.5–9.2) 15 17 0.8 7 25 0.4 7 25 0.4
  RT-qPCR (–) (n = 79) 32 47 34 45 12 67 11 68
  Median viral load 
(log10 copies/mL) 0 0 < 0.01 0 0 0.7 0 0 0.3 0 0 0.4

aRT-qPCR, quantitative reverse transcription–polymerase chain reaction; SARS, severe acute respiratory syndrome; Y, yes; N, no; OR, odds ratio; CI, 95% confidence interval; NPA, nasopharyngeal aspirates

Main Article

Page created: March 29, 2011
Page updated: March 29, 2011
Page reviewed: March 29, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external