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Volume 11, Number 12—December 2005
Research
SARS-CoV Infection in a Restaurant from Palm Civet
Ming Wang*1, Meiying Yan†‡1, Huifang Xu*1, Weili Liang†‡1, Biao Kan†‡1, Bojian Zheng§1, Honglin Chen§1, Han Zheng†‡, Yanmei Xu†‡, Enmin Zhang†‡, Hongxia Wang†‡, Jingrong Ye†‡, Guichang Li†, Machao Li†, Zhigang Cui†‡, Yu-Fei Liu*, Rong-Tong Guo*, Xiao-Ning Liu*, Liu-Hua Zhan*, Duan-Hua Zhou*, Ailan Zhao†‡, Rong Hai†‡, Dongzhen Yu†‡, Yi Guan§, and Jianguo Xu†‡
Table 2
Comparison of signature nucleotide variations in the spike (S) gene of SARS-CoV from various sources*
| Virus | Source | Signature nucleotide variation position of S gene† |
||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||
| 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 4 | 4 | 5 | ||
| 9 | 5 | 5 | 5 | 8 | 8 | 9 | 9 | 9 | 9 | 9 | 3 | 3 | 3 | 4 | 7 | 7 | 8 | 5 | 9 | 0 | ||
| 0 | 1 | 2 | 7 | 7 | 7 | 0 | 2 | 2 | 3 | 5 | 1 | 1 | 3 | 8 | 1 | 8 | 2 | 6 | 7 | 3 | ||
| 7 | 7 | 2 | 0 | 4 | 5 | 6 | 7 | 8 | 0 | 1 | 6 | 7 | 0 | 5 | 9 | 5 | 3 | 6 | 8 | 1 | ||
| Civet007 | Civet, restaurant | T | G | G | C | T | T | C | G | A | G | G | T | T | A | C | G | T | G | C | G | C |
| Civet010 | Civet, restaurant | T | G | G | C | T | T | C | G | A | G | G | T | T | A | C | G | T | G | C | G | C |
| Civet019 | Civet, restaurant | T | G | G | C | T | T | C | G | A | G | G | T | T | A | C | G | T | G | C | G | C |
| Civet020 | Civet, restaurant | T | G | G | C | T | C | C | G | A | G | G | T | T | A | C | G | T | G | C | G | C |
| Civet014 | Civet, restaurant | T | G | G | C | T | C | C | A | A | G | G | T | T | A | C | G | T | G | C | G | C |
| Waitress | Patient 2, waitress | G | A | G | G | |||||||||||||||||
| Customer | Patient 4, customer | G | A | G | G | |||||||||||||||||
| GD03T0013 | Patient 1 | T | G | G | C | T | C | C | A | T | G | G | T | T | A | C | G | T | G | C | G | C |
| SZ3 | Civet, market | C | G | G | C | C | C | T | A | A | A | G | G | C | T | C | C | C | G | C | G | T |
| SZ16 | Civet, market | C | G | G | C | C | C | T | A | A | A | G | G | C | T | C | C | C | G | C | G | T |
| GZ60 | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | C | C | C | G | T | A | T |
| HGZ8L1-A | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | A | T |
| ZS-A | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | A | T |
| ZS-B | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | A | T |
| ZS-C | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | A | T |
| GD01 | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | C | A | T |
| GZ02 | Early phase | C | G | G | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | G | T |
| HSZ-Bb | Early phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | G | T |
| HSZ-Bc | Early phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | G | T |
| HSZ-Cb | Early phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | G | T |
| HSZ-Cc | Early phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | G | T | G | T |
| GZ50 | Middle phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| BJ01 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| BJ03 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| HKU-36871 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| HKU-39849 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| HKU-65806 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| CUHK-W1 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| CUHK-Su10 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| Fra | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| Tor2 | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
| Urbani | Late phase | C | A | A | T | C | C | T | A | T | A | C | G | C | T | T | C | C | T | T | A | T |
*Blank spaces indiate information not available. Early, middle, and late phases indicate when virus was isolated from patients in various stages of the 2003 epidemic. SARS-CoV, severe acute respiratory syndrome.
†Numbers indicate position of signature nucleotide variations on the virus genome based on SARS-CoV Tor2 numbering. The 4 signature nucleotide variations in 286-bp S gene sequences for isolates from 2 restaurant-related patients were identical to 4 of 5 S gene sequences of palm civets at the restaurant.
1These authors contributed equally to this article.
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