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Volume 11, Number 4—April 2005


Childhood Hemolytic Uremic Syndrome, United Kingdom and Ireland

Richard M. Lynn*, Sarah J. O’Brien†1Comments to Author , C. Mark Taylor‡, Goutam K. Adak†, Henrik Chart§, Tom Cheasty§, John E. Coia¶, Iain A. Gillespie†, Mary E. Locking#, William J. Reilly#, Henry R. Smith§, Aoife Waters**, and Geraldine A. Willshaw§
Author affiliations: *Royal College of Paediatrics and Child Health, London, United Kingdom; †Communicable Disease Surveillance Centre, London, United Kingdom; ‡Birmingham Children’s Hospital, Birmingham, United Kingdom; §Health Protection Agency Centre for Infections, London, United Kingdom; ¶Western General Hospital, Edinburgh, United Kingdom; #Scottish Centre for Infection and Environmental Health, Glasgow, United Kingdom; and; **The Children’s Hospital, Dublin, Ireland

Main Article

Table 2

Clinical features and acute complications of diarrhea-associated hemolytic uremic syndrome (HUS) in children from the 1997–2001 British Paediatric Surveillance Unit survey compared with children from the 1985–1988 survey

1985–1988 survey 1997–2001 survey p value
No. of cases 288 413
Cases with a diarrheal prodrome 273 (95%) 395 (96%) 0.6
Mean (range) time from onset of diarrhea to diagnosis of HUS 8 days (1–34) 6 days (range 1–35) <0.001
Severe acute abdominal symptoms 40 (15%) 36 (9%) 0.03
Seizures or other neurologic complications 51(19%) 52 (13%) 0.06
Hypertension 86 (32%) 92 (23%) 0.02
Cardiomyopathy 4 (1%) 7 (2%) 1.0
Diabetes mellitus 4 (1%) 8 (2%) 0.77

Main Article

1Current affiliation: University of Manchester, Salford, United Kingdom