Volume 11, Number 6—June 2005
Research
Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
Jacques Pépin*
and Bokelo Mpia†
and Bokelo Mpia†
Table 1
Demographic and clinical characteristics of all patients with Trypanosoma brucei gambiense trypanosomiasis treated in Nioki hospital, 1982–2001*
| Characteristic | 1982–1985 (%) (n = 1,074) | 1986–1989 (%) (n = 889) | 1990–1993 (%) (n = 535) | 1994–1997 (%) (n = 447) | 1998–2001 (%) (n = 374) | p value |
|---|---|---|---|---|---|---|
| Sex | <0.001 | |||||
| Females | 669 (62) | 472 (53) | 283 (53) | 217 (49) | 161 (43) | |
| Males | 405 | 417 | 252 | 230 | 213 | |
| Age (y) | <0.001 | |||||
| ≤14 | 239 (25) | 178 (20) | 91 (18) | 69 (15) | 63 (17) | |
| 15–49 | 569 (60) | 600 (68) | 353 (69) | 330 (74) | 267 (71) | |
| ≥50 | 146 (15) | 105 (12) | 66 (13%) | 47 (11) | 44 (12) | |
| Area of residence | <0.001 | |||||
| Nioki town | 152 (15) | 212 (24) | 150 (28) | 105 (23) | 114 (30) | |
| Mfimi River | 585 (58) | 329 (37) | 151 (28) | 129 (29) | 119 (32) | |
| Molibampe River | 78 (8) | 79 (9) | 60 (11) | 72 (16) | 49 (13) | |
| Baboma/Basengele | 137 (14) | 146 (16) | 58 (11) | 62 (14) | 43 (11) | |
| Out of district | 61 (6) | 123 (14) | 116 (22) | 79 (18) | 49 (13) | |
| Trypanosomes in lymph node aspirate | <0.001 | |||||
| Yes | 624 (58) | 415 (47) | 180 (34) | 160 (36) | 130 (35) | |
| No | 450 | 474 | 355 | 287 | 244 | |
| Trypanosomes in blood | <0.001 | |||||
| Yes | 313 (29) | 341 (38) | 157 (29) | 138 (31) | 126 (34) | |
| No | 761 | 548 | 378 | 309 | 248 | |
| Trypanosomes in CSF | <0.001 | |||||
| Yes | 135 (13) | 278 (31) | 246 (46) | 239 (53) | 187 (50) | |
| No | 939 | 611 | 289 | 208 | 187 | |
| CSF leukocyte count (per mm3) | <0.001 | |||||
| 1–5 | 407 (38) | 286 (32) | 75 (14) | 32 (7) | 26 (7) | |
| 6–19 | 188 (18) | 120 (13) | 38 (7) | 34 (8) | 38 (10) | |
| 20–99 | 189 (18) | 144 (16) | 122 (23) | 118 (26) | 109 (29) | |
| ≥100 | 289 (27) | 339 (38) | 300 (56) | 263 (59) | 201 (54) | |
| Median CSF leukocyte count (per mm3) | 12 | 31 | 120 | 130 | 112 | <0.001 |
*CSF, cerebrospinal fluid.
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