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Volume 11, Number 7—July 2005
Synopsis

SARS Vaccine Development

Shibo Jiang*Comments to Author , Yuxian He*, and Shuwen Liu*
Author affiliations: *New York Blood Center, New York, New York, USA

Main Article

Table

Comparison of civet SARS-CoV-like virus and the early and late human SARS-CoV*

Characteristics SARS-CoV–like virus Early human SARS-CoV Late human SARS-CoV
Transmission Animal-to-animal Animal/human-to-human Human-to-human
Outbreak No No/local Local/global
Causes disease No Mild Severe
Representative strains SZ3, SZ16 GD03T0013 Tor2, Urbani, BJ01, GZ02
Source Palm civets SARS patients during 2003–2004 epidemic SARS patients during 2002–2003 outbreak
29-nucleotide deletion No No Yes (some have a 415– nucleotide deletion)
Properties of spike protein
Genetic homogenicity Low Low High
Rate of nonsynonymous mutation High High Low
Binding affinity to ACE2 Low Low High

*Information was obtained from references 46. SARS-COV, severe acute respiratory syndrome–associated coronavirus; ACE2, angiotensin-converting enzyme 2.

Main Article

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Page created: April 24, 2012
Page updated: April 24, 2012
Page reviewed: April 24, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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