Volume 11, Number 8—August 2005
Dispatch
Evaluating Antibiograms To Monitor Drug Resistance
Mohamed El-Azizi*, Adnan Mushtaq*, Cheryl Drake†, Jerry Lawhorn†, Joan Barenfanger†, Steven Verhulst*, and Nancy Khardori*
Table A1
Comparison of susceptibility results of common gram-negative bacteria to selected antimicrobial agents in 4 regions of central Illinois*
| Organism/region (no. isolates tested) | % isolates susceptible (no. isolates reported) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP/SUL | CFZ | CFT | CFO | CFA | GNT | TOB | AKN | CIP | LEV | IMI/CIL | TMP/SMX | PIP | |
| Escherichia coli | |||||||||||||
| West (2,600) | 69 (2,600) | 90 (2,600) | 100 (2,347) | – | 98 (1,910) | 97 (2,600) | 98 (2,347) | 100 (2,347) | 92 (978) | 91 (2,369) | 100 (2,600) | 88 (2,347) | 80 (978) |
| Southwest (1,024) | 67 (1,006) | 73 (761) | 100 (1,024) | – | 99 (533) | 97 (1,024) | 99 (1,024) | 100 (906) | 94 (661) | 94 (754) | 100 (906) | 89 (1,024) | 76 (1,006) |
| Central (11,804) | 73 (7,497) | 80 (9,777) | 98 (7,307) | – | 97 (6,175) | 97 (11,683) | 95 (7,271) | 100 (5,615) | 94 (1,063) | 93 (6,689) | 93 (1,364) | 87 (6,570) | 72 (10,371) |
| South (1,682) | 68 (1,682) | 86 (1,682) | 94 (1,682) | – | 98 (1,549) | 97 (1,682) | 99 (1,682) | 100 (1,336) | 91 (115) | 93 (1,336) | 100 (1,682) | 91 (1,682) | 75 (1,603) |
| p value | <0.0001 | <0.0001 | <0.0001 | – | 0.0020 | 0.9999 | <0.0001 | NA | 0.2235 | 0.0049 | <0.0001 | <0.0001 | <0.0001 |
| Pseudomonas aeruginosa | |||||||||||||
| West (1,680) | – | – | – | – | 88 (1,635) | 78 (1,680) | 95 (1,635) | 94 (1,635) | 73 (504) | 86 (1,626) | 91 (1,680) | – | 92 (504) |
| Southwest (357) | – | – | – | – | 90 (350) | 80 (357) | 95 (357) | 96 (250) | 81 (47) | 68 (257) | 94 (250) | – | 91 (350) |
| Central (3,186) | – | – | – | – | 85 (2,710) | 77 (3,186) | 91 (3,113) | 95 (1,870) | 67 (2,890) | 60 (1,640) | 89 (1,367) | – | 93 (2,981) |
| South (591) | – | – | – | – | 67 (535) | 55 (591) | 74 (591) | 95 (522) | 67 (69) | 45 (522) | 84 (236) | – | 81 (586) |
| p value | – | – | – | – | <0.0001 | <0.0001 | <0.0001 | 0.0364 | 0.0128 | <0.0001 | 0.0006 | – | <0.0001 |
| Proteus mirabilis | |||||||||||||
| West (663) | 95 (663) | 91 (663) | 100 (625) | 96 (480) | 99 (568) | 95 (663) | 98 (625) | 99 (625) | 85 (480) | 86 (653) | 99 (66) | 89 (663) | 94 (290) |
| Southwest (294) | 94 (285) | 78 (264) | 100 (294) | 100 (155) | 100 (185) | 97 (294) | 97 (294) | 98 (185) | 89 (27) | 93 (194) | 97 (185) | 86 (294) | 81 (285) |
| Central (2,469) | 92 (1,445) | 84 (1,877) | 98 (1,417) | 98 (867) | 84 (1,423) | 91 (2,469) | 91 (1,760) | 94 (1,421) | 71 (2,009) | 73 (1,489) | 99 (311) | 82 (1,882) | 88 (2,072) |
| South (483) | 81 (483) | 73 (483) | 100 (483) | 100 (483) | 99 (451) | 97 (483) | 95 (483) | 100 (483) | 41 (213) | 77 (483) | 98 (483) | 79 (483) | 72 (428) |
| p value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.1139 | <0.0001 | <0.0001 |
| Klebsiella pneumoniae | |||||||||||||
| West (1,236) | – | 90 (1,236) | 99 (1,192) | 97 (395) | 99 (1,109) | 99 (1,236) | 100 (1,335) | 100 (1,161) | 96 (426) | 96 (1,013) | 100 (1,176) | 93 (1,236) | 73 (426) |
| Southwest (296) | – | 82 (222) | 93 (296) | 95 (116) | 95 (290) | 98 (290) | 99 (296) | 100 (190) | 97 (222) | 89 (164) | 100 (190) | 95 (290) | 86 (290) |
| Central (3,064) | – | 89 (2,507) | 98 (2,048) | 98 (1,505) | 85 (1,660) | 99 (3,064) | 99 (1,974) | 93 (1,604) | 95 (2,606) | 93 (1,523) | 100 (201) | 96 (2,778) | 85 (2,572) |
| South (409) | – | 95 (409) | 100 (409) | 99 (409) | 92 (409) | 97 (409) | 98 (409) | 100 (409) | 97 (161) | 97 (409) | 93 (409) | 98 (409) | 96 (382) |
| p value | – | <0.0001 | <0.0001 | 0.0246 | <0.0001 | 0.0003 | 0.0002 | <0.0001 | 0.3802 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Serratia marcescens | |||||||||||||
| West (251) | 10 (236) | – | 92 (11) | 95 (81) | 93 (245) | 98 (251) | 96 (229) | 98 (251) | 87 (81) | 94 (214) | 99 (236) | 95 (251) | 84 (81) |
| Southwest (9) | 22 (4) | – | 89 (9) | 95 (9) | 95 (9) | 100 (9) | 99 (9) | 100 (9) | 100 (5) | 95 (9) | 100 (9) | 99 (9) | 92 (9) |
| Central (757) | 26 (396) | – | 95 (482) | 90 (440) | 97 (382) | 100 (757) | 98 (539) | 98 (321) | 80 (557) | 76(343) | 100 (49) | 98 (552) | 93 (578) |
| South (44) | 15 (33) | – | 89 (44) | 97 (33) | 83 (33) | 93 (44) | 73 (44) | 100 (33) | 84 (33) | 100 (33) | 93 (44) | 93 (44) | 78 (41) |
| p value | <0.0001 | – | 0.2803 | 0.2938 | 0.0006 | <0.0001 | <0.0001 | 0.8412 | 0.3398 | <0.0001 | 0.0176 | 0.0453 | <0.0001 |
| Enterobacter spp. | |||||||||||||
| West (676) | – | – | 80 (657) | 78 (173) | 79 (624) | 95 (657) | 96 (657) | 99 (649) | 94 (181) | 95 (592) | 100 (645) | 94 (676) | 81 (269) |
| Southwest (201) | – | – | 79 (201) | 95 (43) | 81 (201) | 100 (201) | 100 (201) | 100 (101) | 98 (43) | 92 (101) | 100 (101) | 96 (201) | 81 (201) |
| Central (1,334) | – | – | 78 (567) | 92 (706) | 83 (735) | 86 (1,111) | 99 (804) | 100 (555) | 97 (1,246) | 69 (775) | 100 (226) | 99 (1,201) | 83 (216) |
| South (121) | – | – | 83 (96) | 65 (92) | 80 (92) | 97 (121) | 97 (121) | 100 (96) | 92 (64) | 93 (96) | 92 (121) | 92 (121) | 85 (112) |
| p value | – | – | 0.6119 | <0.0001 | 0.3167 | <0.0001 | <0.0001 | 0.0151 | 0.0411 | <0.0001 | <0.0001 | <0.0001 | 0.6992 |
| Citrobacter freundii | |||||||||||||
| West (245) | 64 (245) | – | 77 (233) | 82 (126) | 83 (245) | 95 (245) | 97 (233) | 100 (233) | 91 (126) | 91 (192) | 99 (233) | 86 (245) | 86 (126) |
| Southwest (38) | 87 (38) | – | 100 (38) | 100 (38) | 92 (38) | 100 (38) | 100 (38) | 100 (24) | 98 (24) | 93 (24) | 100 (14) | 93 (14) | 97 (38) |
| Central (578) | 80 (402) | – | 81 (444) | 83 (332) | 83 (394) | 95 (578) | 96 (408) | 96 (302) | 89 (510) | 93 (238) | 99 (145) | 93 (517) | 79 (416) |
| South (85) | 90 (17) | – | 84 (85) | 80 (85) | 78 (85) | 93 (85) | 99 (85) | 100 (68) | 79 (63) | 79 (68) | 93 (85) | 85 (85) | 76 (75) |
| p value | <0.0001 | – | 0.0077 | 0.0479 | 0.2716 | 0.4270 | 0.3703 | 0.0043 | 0.0544 | 0.0102 | 0.0018 | 0.0062 | 0.0136 |
*AMP/SUL, ampicillin/sulbactam; CFZ, cefazolin; CFT, ceftriaxone; CFO, cefotaxime; CFA, ceftazidime; GNT, gentamicin; TOB, tobramycin; AKN, amikacin; CIP, ciprofloxacin; LEV, levofloxacin; IMI/CIL, imipenem/cilastatin; TMP/SMX, trimethoprim/sulfamethoxazole; PIP, piperacillin; NA, not applicable.
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