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Volume 12, Number 1—January 2006
Research

Economics of Neuraminidase Inhibitor Stockpiling for Pandemic Influenza, Singapore

Vernon J. Lee*Comments to Author , Kai Hong Phua†, Mark I. Chen*, Angela Chow‡, Stefan Ma‡, Kee Tai Goh‡, and Yee Sin Leo*
Author affiliations: *Tan Tock Seng Hospital, Singapore; †National University of Singapore, Singapore; ‡Ministry of Health, Singapore

Main Article

Table 4

Outcomes by age and risk groups*

Risk and age group, y Strategy option Stockpile cost (1 cycle, million $) Mean lives saved compared with no action Mean cost per life saved compared with no action (million $) Mean benefit compared with no action (million $)
Low risk, age <1–19 No action NA Deaths: 17 NA Cost: 122
Only Rx † 17 8 Dominates§ 87
12 wk ‡ 251 11 41 –315
24 wk ‡ 485 14 70 –717
Low risk, age 20–64 No action N/A Deaths: 42 N/A Cost: 507
Only Rx 49 21 Dominates§ 382
12 wk 741 29 40 –808
24 wk 1,433 36 73 –1,999
Low risk, age >65 No action NA Deaths: 185 NA Cost: 57
Only Rx 3 60 Dominates§ 28
12 wk 49 108 0.9 –43
24 wk 95 148 1.3 –115
High risk, age >1–19 No action NA Deaths: 92 NA Cost: 186
Only Rx 2 45 Dominates§ 94
12 wk 28 63 1.0 83
24 wk 54 78 1.8 66
High risk, age 20–64 No action NA Deaths: 220 NA Cost: 443
Only Rx 6 109 Dominates§ 235
12 wk 85 153 1.1 175
24 wk 165 189 2.0 100
High risk, age >65 No action NA Deaths: 547 NA Cost: 117
Only Rx 2 179 Dominates§ 44
12 wk 29 321 0.17 24
24 wk 55 438 0.25 0.1

*Mean values are shown, with all costs in 2004 Singapore dollars; NA, not applicable.
†Only Rx refers to treatment-only, without prophylaxis.
‡12 and 24 wk refer to number of weeks of prophylaxis for the respective risk and age groups.
§Treatment-only dominates no action because treatment-only saves lives and is less costly overall.

Main Article

1"Dominate" is a term used in cost-effectiveness analyses and refers to a strategy that is both more efficacious and less costly than another strategy.

Page created: February 16, 2012
Page updated: February 16, 2012
Page reviewed: February 16, 2012
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