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Volume 12, Number 3—March 2006
Dispatch

Molecular Analysis of Fluoroquinolone-resistant Salmonella Paratyphi A Isolate, India

Satheesh Nair*, Madhulika Unnikrishnan†, Keith Turner*, Subash Chandra Parija†, Carol Churcher*, John Wain*, and Belgode Narasimha Harish†Comments to Author 
Author affiliations: *The Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom; †Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India

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Table 2

Presence of qnr and mutations in DNA gyrase and topoisomerase IV genes of Salmonella enterica serovar Paratyphi A strains associated with decreased susceptibility or resistance to ciprofloxacin*

Country Year MIC (μg/mL)
Cp Nal qnr gyrA parC Reference
India 1999 0.38 >256 ND Ser83→Phe ND (8)
Bangladesh 1999 0.5 >256 ND Asp87→Gly ND (8)
India 1999 0.5 >256 ND Ser83→Phe ND (8)
Hong Kong 2000 0.5 >256 ND Ser83→Tyr NM (9)
Japan 2002 >128 >256 ND Ser83→Phe, Asp87→Asn Glu84→Lys (7)
India 2002 8 >256 NP Ser83→Phe, Asp87→Gly Ser80→Arg† This study

*No mutations were detected in gyrB and parE. Cp, ciprofloxacin; Nal, nalidixic acid; ND, not determined; NP, not present; NM, no mutation within the quinolone resistance–determining region.
†European Molecular Biology Laboratory accession no. AM050347.

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