Volume 12, Number 3—March 2006
Research
Chemoprophylaxis and Malaria Death Rates
Gérard Krause*
, Irene Schöneberg*, Doris Altmann*, and Klaus Stark*
, Irene Schöneberg*, Doris Altmann*, and Klaus Stark*
Table 1
Univariate analysis of risk factors for fatal outcome of imported Plasmodium falciparum malaria in nonimmune patients, Germany 1993–2004
| Risk factor | Odds ratio | 95% confidence interval | p value |
|---|---|---|---|
| Chemoprophylaxis, total (n = 3,752) | |||
| No | 1 | ||
| Yes | 0.743 | 0.493-1.121 | 0.157 |
| Chemoprophylaxis, comparison of regimens (n = 3,752) | 0.047 | ||
| None (n = 2,171) | 1 | ||
| Chloroquine alone (n = 485) | 1.372 | 0.824-2.285 | 0.225 |
| Proguanil alone (n = 59) | 0.550 | 0.075-4.030 | 0.556 |
| Mefloquine alone (n = 322) | 0.503 | 0.201-1.258 | 0.142 |
| Chloroquine plus proguanil (n = 459) | 0.280 | 0.102-0.773 | 0.014 |
| Other (n = 256)* | 0.765 | 0.328-1.784 | 0.536 |
| Compliance of chemoprophylaxis (n = 3717) | 0.293† | ||
| No chemoprophylaxis | 1 | ||
| Chemoprophylaxis with incomplete or unknown compliance | 0.829 | 0.535-1.284 | 0.401 |
| Chemoprophylaxis complete | 0.538 | 0.231-1.249 | 0.149 |
| Age (n = 3,844) | |||
| Continuously (by year) | 1.055 | 1.040-1.070 | <0.001 |
| Sex (n = 3,901) | |||
| Female | 1 | ||
| Male | 1.141 | 0.768-1.695 | 0.515 |
| Country of infection in Africa (n = 3,832) | |||
| No | 1 | ||
| Yes | 3.642 | 1.150-11.529 | 0.028 |
| Reporting year (n = 3,935) | 0.004† | ||
*235 were combinations of drugs that are not officially recommended regimens, 15 were doxycycline alone, and 6 were atovaquone/proguanil.
†Overall p value for the categoric variable.
Page created: January 27, 2012
Page updated: January 27, 2012
Page reviewed: January 27, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.