Volume 12, Number 5—May 2006
THEME ISSUE
Tuberculosis Special Section
Research
Mycobacterium tuberculosis and Rifampin Resistance, United Kingdom
I-Ching Sam*1, Francis Drobniewski*
, Philip More*, Melanie Kemp*, and Timothy Brown*
, Philip More*, Melanie Kemp*, and Timothy Brown*
Table 5
Results of LiPA in detecting MTBC in clinical specimens in which MTBC was correctly identified and cultured, stratified by history of antituberculous treatment*
| Treatment history/AFB smear result | No. positive/no. tested (%) |
||||
|---|---|---|---|---|---|
| Concordance | Sensitivity | Specificity | PPV | NPV | |
| Current or within 3 mo | 86/182 (47.3) | 48/67 (71.6) | 38/115 (33.0) | 48/125 (38.4) | 38/57 (66.7) |
| Positive | 61/132 (46.2) | 46/55 (83.6) | 15/77 (19.5) | 46/108 (42.6) | 15/24 (62.5) |
| Negative/not done | 25/50 (50.0) | 2/12 (16.7) | 23/38 (60.5) | 2/17 (11.8) | 23/33 (69.7) |
| Adjusted values† | 86/139 (61.9) | 48/67 (71.6) | 38/72 (52.8) | 48/82 (58.5) | 38/57 (66.7) |
| Positive | 61/99 (61.6) | 46/55 (83.6) | 15/44 (34.1) | 46/75 (61.3) | 15/24 (62.5) |
| Negative/not done | 25/40 (62.5) | 2/12 (16.7) | 23/28 (82.1) | 2/7 (28.6) | 23/33 (69.7) |
| >3 mo ago | 85/106 (80.2) | 42/53 (79.2) | 43/53 (81.1) | 42/52 (80.8) | 43/54 (79.6) |
| Positive | 54/65 (83.1) | 40/45 (88.9) | 14/20 (70.0) | 40/46 (87.0) | 14/19 (73.7) |
| Negative/not done | 31/41 (75.6) | 2/8 (25.0) | 29/33 (87.9) | 2/6 (33.3) | 29/35 (82.9) |
| Adjusted values† | 85/102 (83.3) | 42/53 (79.2) | 43/49 (87.8) | 42/48 (87.5) | 43/54 (79.6) |
| Positive | 54/63 (85.7) | 40/45 (88.9) | 14/18 (90.9) | 40/44 (90.9) | 14/19 (73.7) |
| Negative/not done | 31/39 (79.5) | 2/8 (25.0) | 29/31 (93.5) | 2/4 (50.0) | 29/35 (82.5) |
| No stated treatment | 1,497/1,634 (91.6) | 692/798 (86.7) | 805/836 (96.3) | 692/723 (95.7) | 805/911 (88.4) |
| Positive | 845/902 (93.7) | 661/698 (94.7) | 184/204 (90.2) | 661/681 (97.1) | 184/221 (83.3) |
| Negative/not done | 652/732 (89.1) | 31/100 (31.0) | 621/632 (98.3) | 21/42 (73.8) | 621/690 (90.0) |
| Adjusted values† | 1,497/1,634 (91.6) | 692/798 (86.7) | 805/836 (96.3) | 692/723 (95.7) | 805/911 (88.4) |
| Positive | 845/892 (94.7) | 661/698 (94.7) | 184/194 (94.8) | 661/671 (98.5) | 184/221 (83.3) |
| Negative/not done | 652/728 (89.6) | 31/100 (31.0) | 621/628 (98.9) | 31/38 (81.6) | 621/690 (90.0) |
*LiPA, line probe assay; MTBC, Mycobacterium tuberculosis complex; AFB, acid-fast bacilli; PPV, positive predictive value; NPV, negative predictive value.
†Excludes samples from patients with a microbiologic diagnosis of MTBC made at the Mycobacterium Reference Unit in the last 18 or subsequent 3 months.
1Current affiliation: University of Malaya, Kuala Lumpur, Malaysia
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