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Volume 13, Number 1—January 2007


Ophthalmic Surgery in Prion Diseases

Tsuyoshi Hamaguchi*1, Moeko Noguchi-Shinohara*, Yosikazu Nakamura†2, Takeshi Sato‡2, Tetsuyuki Kitamoto§2, Hidehiro Mizusawa¶2, and Masahito Yamada*2Comments to Author 

Author affiliations: *Kanazawa University Graduate School of Medical S cience, Kanazawa, Japan; †Jichi Medical University, Shimotsuke, Japan; ‡National Center for Neurology and Psychiatry, Ichikawa, Japan; §Tohoku University Graduate School of Medicine, Sendai, Japan; ¶Tokyo Medical and Dental University, Tokyo, Japan;

Main Article

Table 1

Characteristics of sCJD patients and ophthalmic surgery*

Patient no. Sex/age, y† Disease duration,
mo‡ Symptom at sCJD onset Ophthalmic disease Interval, mo§ Visual symptoms after surgery Reused instruments Cleaning method
1 M/81 8 Visual Cataract 4 NA NA NA
2 M/61 15 Dementia Cataract 0 Improved Yes Autoclave
(135°C for 9 min)
3 F/64 20 Visual Cataract 14 Not changed Yes EOG
4 F/59 3 Dementia Detached retina –1 Improved Yes EOG
5 F/57 10 Dementia Cataract 10 NA NA NA
6 F/79 5 Dementia Cataract –1 Improved Yes EOG
7 M/74 16 Visual Cataract 3 Improved Yes Autoclave (132°C for 10 min), EOG
8 F/63 5 Visual Cataract 1 Deteriorated Yes Autoclave
(132°C for 10 min)
9 M/79 6 Gait disturbance Cataract 2 Not changed Yes Autoclave
(121°C for 60 min)
10 F/66 3 Dementia Cataract 1 NA NA NA

*sCJD, sporadic Creutzfeldt-Jakob disease; visual, visual impairment; NA, not available; EOG, ethylene oxide gas.
†At sCJD onset.
‡Disease duration, the duration from onset to akinetic mutism state or death if the patients never displayed akinetic mutism.
§Between surgery and sCJD symptoms.

Main Article

1Current affiliation: Ishikawa Prefecture Central Hospital, Kanazawa, Japan

2Member, Creutzfeldt-Jakob Disease Surveillance Committee, Japan