Volume 13, Number 11—November 2007
Dispatch
Characterization of Hemorrhagic Fever with Renal Syndrome Caused by Hantaviruses, Estonia
Irina Golovljova*†‡, Veera Vasilenko*, Vassili Mittženkov*, Tiina Prükk§, Elviira Seppet§, Sirkka Vene†, Bo Settergren¶, Alexander Plyusnin†#, and Åke Lundkvist†‡
Table 2
Frequency of clinical symptoms and laboratory findings in 24 HFRS patients, Estonia*
| Findings | No. patients (%) |
||
|---|---|---|---|
| PUUV, n = 20 (%) | SAAV, n = 3 (%) | DOBV, n = 1 | |
| Signs and symptoms | |||
| Fever | 20 (100) | 3 (100) | 1 |
| Headache | 8 (40) | 3 (100) | 0 |
| Abdominal pain | 11 (55) | 3 (100) | 1 |
| Back pain | 16 (80) | 2 (67) | 1 |
| Nausea/vomiting | 11 (55) | 2 (67) | 1 |
| Hemorrhage | 2 (10) | 1 (33) | 0 |
| Visual impairment | 5 (25) | 0 | 0 |
| Diarrhea | 3 (15) | 2 (67) | 1 |
| Oliguria (<400 mL/d) | 11 (55) | 3 (100) | 1 |
| Polyuria (>2,500 mL/d) | 9 (45) | 2 (67) | 1 |
| Hematuria (microscopic) | 20 (100) | 3 (100) | 0 |
| Hemodialysis | 1 (5) | 1 (33) | 0 |
| Laboratory findings | Mean value (% patients with abnormal findings), range | ||
| Leukocyte count, 4–10 × 109/L | 11 (58), 5.7–24.4 | 9 (33), 8.1–11.3 | 5 |
| Thrombocyte count, 100–400 × 109/L | 120 (57), 12.6–350 | 126 (33), 90–163 | 174 |
| C-reactive protein <10 mg/L | 84 (94), 9.7–229.8 | 69 (100), 52–95 | 168 |
| Serum urea, 2.8–8.3 mmol/L | 23 (94), 5.0–87.0 | 31 (100), 20.1–42.5 | ND |
| Serum creatinine, 35–115 μmol/L | 303 (100), 120–1,124 | 606 (100)†, 489–796 | 98 |
| AST <26 U/L | 74 (100), 28–205 | 56 (100), 39–77 | 122 |
| ALT <35 U/L | 62 (88), 20–233 | 71 (100), 41–123 | ND |
| Proteinuria (g/L) | 3 (95), 0.25–11.8 | 7 (100), 1.06–17.8 | 1 |
*HFRS, hemorrhagic fever with renal syndrome; PUUV, Puumala virus; SAAV, Saaremaa virus; DOBV, Dobrava virus; AST, aspartate aminotransferase; ALT, alanine aminotransferase.
†Statistically significant result, p<0.05.
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