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Volume 13, Number 11—November 2007

Dispatch

Viral Load as Predictor of Crimean-Congo Hemorrhagic Fever Outcome

Darja Duh*, Ana Saksida*, Miroslav Petrovec*, Salih Ahmeti†, Iusuf Dedushaj‡, Marcus Panning§, Sung Sup Park§, and Tatjana Avšič-Županc*Comments to Author 
Author affiliations: *Institute of Microbiology and Immunology, Ljubljana, Slovenia; †Clinic of Infectious Diseases, Pristina, Kosovo; ‡National Institute of Public Health, Pristina, Kosovo; §Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;

Main Article

Table

Detection of CCHF viral load by real-time RT-PCR in serum of patients with acute CCHF, Kosovo*

Patient no. Disease severity Day of illness IgM titer IgG titer Viral load (copies/mL)
1 Fatal 2 Neg Neg 6.5100 × 108
2 Fatal 3 Neg Neg 2.5040 × 109
3 Fatal 4 Neg Neg 2.7400 × 109
4 Fatal 9 Neg Neg 3.3840 × 109
5 Fatal 4 1,600 Neg 1.0160 × 108
6 Fatal 6 3,200 Neg 1.3450 × 1010
7 Fatal 7 400 Neg 1.8675 × 109
8 Fatal 7 800 Neg 3.4800 × 109
9 Fatal 7 800 Neg 1.2920 × 109
10 Severe 8 >6,400 Neg 1.6050 × 106
18 >6,400 400 1.1500 × 105
11 Severe 9 Neg Neg 2.3250 × 107
24 >6,400 >6,400 Neg
12 Severe 4 800 Neg 3.3900 × 106
16 6,400 3,200 Neg
13 Severe 2 Neg Neg 1.0430 × 109
9 >6,400 400 3.1200 × 103
42 > 6,400 3,200 Neg
14 Severe 8 Neg Neg 8.1000 × 106
14 6,400 Neg 2.0100 × 103
15 Severe 3 Neg Neg 3.8100 × 107
14 6,400 200 Neg
16 Severe 3 >1,600 Neg 2.5235 × 106
6 >800 >800 2.2350 × 104
17 Severe 4 Neg Neg 3.3600 × 107
10 >6,400 100 3.8100 × 104
18 Severe 2 Neg Neg 7.8500 × 107
9 6,400 400 3.2000 × 103
23 >6,400 >6,400 Neg
19 Moderate 12 >6,400 Neg 5.7525 × 104
17 >6,400 800 Neg
20 Moderate 9 >6,400 1,600 1.9600 × 103
11 >6,400 3,200 Neg
21 Moderate 12 >6,400 800 1.9191 × 105
13 >6,400 3,200 1.0240 × 104
32 >6,400 >6,400 Neg
22 Moderate 10 >6,400 Neg 4.6400 × 104
19 >6,400 >6,400 1.2000 × 103
26 >6,400 >6,400 Neg
23 Moderate 9 6,400 6,400 7.6800 × 103
20 >6,400 >6,400 7.5000 × 102
24 Moderate 7 400 Neg 7.4400 × 105
18 >6,400 6,400 Neg

*CCHF, Crimean-Congo hemorrhagic fever: RT-PCR, reverse transcription–PCR; Ig, immunoglobulin; neg, negative result.

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Page created: July 05, 2010
Page updated: July 05, 2010
Page reviewed: July 05, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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