Literature Review and Case Histories of Histoplasma capsulatum var. duboisii Infections in HIV-infected Patients
Pierre Loulergue*†, Frédéric Bastides‡, Véronique Baudouin§, Jacques Chandenier‡, Patricia Mariani-Kurkdjian§, Bertrand Dupont*†, Jean-Paul Viard*†, Françoise Dromer¶, and Olivier Lortholary†¶
Author affiliations: *University Paris V, Paris, France; †Hôpital Necker-Enfants Malades, Paris, France; ‡Centre Hospitalier Universitaire Bretonneau, Tours, France; §Hôpital Robert Debré, Paris, France; ¶Institut Pasteur, Paris, France;
Main Article
Table 2
Comparison of clinical and microbiologic findings of HIV-infected and immunocompetent patients with histoplasmosis due to variety duboisii*â€
Characteristic |
HIV positive (n = 17) |
HIV negative (n = 20) |
Age, y (range) |
35 (2–65) |
34 (8–62) |
Sex (M:F)
|
12:5
|
19:1
|
Visceral localizations |
|
|
Lymph nodes |
53 |
65 |
Skin |
59 |
40 |
Bones |
18 |
25 |
Lungs |
0†|
35†|
Gastrointestinal |
12 |
5 |
Disseminated
|
85â€
|
55â€
|
Clinical manifestations |
|
|
Fever |
58†|
15†|
Weight loss, asthenia, anorexia |
54 |
30 |
Respiratory symptoms |
0 |
20 |
Hepatosplenomegaly
|
12
|
15
|
Diagnosis sites |
|
|
Lymph nodes |
24 |
45 |
Skin |
48 |
35 |
Bone marrow |
18 |
0 |
Bone |
12 |
5 |
Gastrointestinal |
6 |
5 |
Pus |
6 |
25 |
Lung
|
0â€
|
25â€
|
Mycologic diagnosis |
|
|
Direct examination |
100 |
40 |
Culture |
64 |
65 |
Blood culture
|
12
|
0
|
Treatment |
|
|
Amphotericin B |
66 |
80 |
Ketoconazole |
12 |
35 |
Itraconazole |
64 |
20 |
Fluconazole
|
12
|
0
|
Outcome |
|
|
Relapse |
12 |
40 |
Death |
24 |
5 |
Main Article
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