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Volume 13, Number 2—February 2007
Synopsis

Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections

Janie Parrino*, Richard S. Hotchkiss†, and Mike Bray*Comments to Author 
Author affiliations: *National Institutes of Health, Bethesda, Maryland, USA; †Washington University School of Medicine, Saint Louis, Missouri, USA;

Main Article

Table 2

Antiapoptotic therapeutic approaches for prevention of lymphocyte apoptosis in murine models of sepsis

StrategyInterventionReference
Prevent triggering of extrinsic pathway
Blockade of Fas ligand by using Fas fusion protein
 (27)
Prevent triggering of extrinsic pathway
Prevent Fas expression by using siRNA
 (28)
Prevent initiation
Anti-CD40 agonist antibodies
 (29)
Prevent initiation
Treatment with Bcl-2 agonist peptides
 (30)
Prevent triggering of intrinsic pathway
Antiretroviral protease inhibitors
 (31)
Prevent execution phase
Anticaspase-8 siRNA
 (28)
Prevent execution phaseTreatment with caspase inhibitors (32,33)

Main Article

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Page created: June 29, 2010
Page updated: June 29, 2010
Page reviewed: June 29, 2010
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