Volume 13, Number 4—April 2007
Research
Global Distribution of Panton-Valentine Leukocidin–positive Methicillin-resistant Staphylococcus aureus, 2006
Table 1
Geographic distribution of PVL-positive CA-MRSA clones according to their agr-type, ST, and spa type*
agr type | ST (CC) | No. (%) | spa type (spa CC) | No. (%) | Location |
Other reports in literature | |
---|---|---|---|---|---|---|---|
Detected before 2003 | Newly detected (this work) | ||||||
agr1 | 46 (9.8) | ||||||
ST8 (8) | 25 (54.3) | USA (4) | Netherlands, France, Spain, | N. Norway (23) | |||
Switzerland, French Polynesia | Greece (24) | ||||||
t008 (s) | 25 (100.0) | ||||||
ST59 | 7 (15.2) | USA (4) | Netherlands, France, Singapore | Taïwan (25) | |||
t437 (8) | 6 (85.7) | ||||||
t216 (8) | 1 (14.3) | ||||||
ST22 (22) | 3 (6.5) | Netherlands, Germany | |||||
t005 (4) | 2 (66.7) | ||||||
t310 (4) | 1 (33.3) | ||||||
ST766 (22) | 1 (2.2) | Singapore | |||||
t1276 (4) | 1 (100.0) | ||||||
ST377 | 10 (21.7) | Netherlands, France, Greece, Switzerland, Australia | |||||
t355 (6) | 9 (90.0) | ||||||
t595 (6) |
1 (10.0) |
||||||
agr2 | 9 (1.9) | ||||||
ST5 (5) | 9 (100.0) | France, Switzerland, Algeria | |||||
t311 (5) | 5 (55.5) | ||||||
t1277 | 3 (33.3) | ||||||
t450 |
1 (11.1) |
||||||
agr3 | 414 (88.3) | ||||||
ST80 | 357 (83.2) | France, Switzerland (4) | Algeria, Singapore, Romania, Germany, Belgium, Greece, Slovenia, Netherlands | Denmark (7), Sweden (7), notheren Norway (23), England (26), Finland (27), Libya (28), Croatia (29), Scotland (7), Greece (24) | |||
t044 (1) | 333 (93.3) | ||||||
t131 (1) | 9 (2.5) | ||||||
t376 (1) | 8 (2.2) | ||||||
t639 (1) | 2 (0.6) | ||||||
t237 (1) | 1 (0.3) | ||||||
t1199 (1) | 1 (0.3) | ||||||
t1201 (1) | 1 (0.3) | ||||||
t1206 (1) | 1 (0.3) | ||||||
t1200 (†) | 1 (0.3) | ||||||
ST30 (30) | 20 (4.8) | New Zealand, Western Samoa (4) | Netherlands, Australia, Japan, Switzerland, Singapore, China, French Polynesia | Sweden (30), Brazil (31), Uruguay (32), England (26), Hong Kong (10) | |||
t019 (2) | 17 (75.0) | ||||||
t021 (2) | 1 (5.0) | ||||||
t318 (2) | 1 (5.0) | ||||||
t1273 (2) | 1 (5.0) | ||||||
ST37 (30) | 1 (0.2) | Netherlands | |||||
t914 (2) | 1 (100.0) | ||||||
ST93 | 4 (1.0) | Australia (4) | |||||
t202 (s) | 4 (100.0) | ||||||
ST1 | 32 (7.7) | USA (4) | France, Singapore | Switzerland (28), Canada (33) | |||
t128 (3) | 18 (56.2) | ||||||
t125 (3) | 3 (9.4) | ||||||
t558 (3) | 1 (3.1) | ||||||
t175 (7) | 8 (25.0) | ||||||
t1274 (7) | 1 (3.1) | ||||||
t1272 (s) | 1 (3.1) |
*PVL, Panton-Valentine leukodin; CA-MRSA, community-acquired methicillin-resistant Staphylococcus aureus; agr, accessory gene regulator; ST, sequence type; CC, clonal complexes; spa CC, spa clonal complexes.
†Excluded because <3 repeats; s, singleton.
References
- Naimi TS, LeDell KH, Como-Sabetti K, Borchardt SM, Boxrud DJ, Etienne J, Comparison of community- and health care–associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003;290:2976–84. DOIPubMedGoogle Scholar
- Bocchini CE, Hulten KG, Mason EO Jr, Gonzalez BE, Hammerman WA, Kaplan SL. Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children. Pediatrics. 2006;117:433–40. DOIPubMedGoogle Scholar
- Garnier F, Tristan A, Francois B, Etienne J, Delage-Corre M, Martin C, Pneumonia and new methicillin-resistant Staphylococcus aureus clone. Emerg Infect Dis. 2006;12:498–500.PubMedGoogle Scholar
- Vandenesch F, Naimi T, Enright MC, Lina G, Nimmo GR, Heffernan H, Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis. 2003;9:978–84.PubMedGoogle Scholar
- Dufour P, Gillet Y, Bes M, Lina G, Vandenesch F, Floret D, Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis. 2002;35:819–24. DOIPubMedGoogle Scholar
- Wannet WJ, Heck ME, Pluister GN, Spalburg E, van Santen MG, Huijsdans XW, Panton-Valentine leukocidin positive MRSA in 2003: the Dutch situation. Euro Surveill. 2004;9:28–9.PubMedGoogle Scholar
- Faria NA, Oliveira DC, Westh H, Monnet DL, Larsen AR, Skov R, Epidemiology of emerging methicillin-resistant Staphylococcus aureus (MRSA) in Denmark: a nationwide study in a country with low prevalence of MRSA infection. J Clin Microbiol. 2005;43:1836–42. DOIPubMedGoogle Scholar
- Roberts JC, Krueger RL, Peak KK, Veguilla W, Cannons AC, Amuso PT, Community-associated methicillin-resistant Staphylococcus aureus epidemic clone USA300 in isolates from Florida and Washington. J Clin Microbiol. 2006;44:225–6. DOIPubMedGoogle Scholar
- Pan ES, Diep BA, Charlebois ED, Auerswald C, Carleton HA, Sensabaugh GF, Population dynamics of nasal strains of methicillin-resistant Staphylococcus aureus—and their relation to community-associated disease activity. J Infect Dis. 2005;192:811–8. DOIPubMedGoogle Scholar
- Ho PL, Cheung C, Mak GC, Tse CW, Ng TK, Cheung CH, Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong. Diagn Microbiol Infect Dis. 2006;[Sep 19; Epub ahead of print]
- Vlack S, Cox L, Peleg AY, Canuto C, Stewart C, Conlon A, Carriage of methicillin-resistant Staphylococcus aureus in a Queensland Indigenous community. Med J Aust. 2006;184:556–9.PubMedGoogle Scholar
- Hsu LY, Tristan A, Koh TH, Bes M, Etienne J, Kurup A, Community associated methicillin-resistant Staphylococcus aureus, Singapore. Emerg Infect Dis. 2005;11:341–2.PubMedGoogle Scholar
- Moran GJ, Krishnadasan A, Gorwitz RJ, Fosheim GE, McDougal LK, Carey RB, Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355:666–74. DOIPubMedGoogle Scholar
- Del Giudice P, Blanc V, Durupt F, Bes M, Martinez JP, Counillon E, Emergence of two populations of methicillin-resistant Staphylococcus aureus with distinct epidemiological, clinical and biological features, isolated from patients with community-acquired skin infections. Br J Dermatol. 2006;154:118–24. DOIPubMedGoogle Scholar
- Jarraud S, Mougel C, Thioulouse J, Lina G, Meugnier H, Forey F, Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun. 2002;70:631–41. DOIPubMedGoogle Scholar
- Oliveira DC, de Lencastre H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2002;46:2155–61. DOIPubMedGoogle Scholar
- Tristan A, Ying L, Bes M, Etienne J, Vandenesch F, Lina G. Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections. J Clin Microbiol. 2003;41:4465–7. DOIPubMedGoogle Scholar
- Strommenger B, Kettlitz C, Werner G, Witte W. Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus. J Clin Microbiol. 2003;41:4089–94. DOIPubMedGoogle Scholar
- Mellmann A, Friedrich AW, Rosenkotter N, Rothganger J, Karch H, Reintjes R, Automated DNA sequence-based early warning system for the detection of methicillin-resistant Staphylococcus aureus outbreaks. PLoS Med. 2006;3:e33. DOIPubMedGoogle Scholar
- Harmsen D, Claus H, Witte W, Rothganger J, Turnwald D, Vogel U. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol. 2003;41:5442–8. DOIPubMedGoogle Scholar
- Sammeth M, Weiniger T, Harmsen D, Stoye J. Alignment of Tandem Repeats with Excision, Duplication, Substitution and Indels (EDSI). Proceedings of WABI, Mallorca, Spain, 2005 Oct 3–6. In: Casadio R, Myers G, editors. Algorithms in bioinformatics. Vol. 3692. New York: Springer-Verlag; 2005.
- Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol. 2000;38:1008–15.PubMedGoogle Scholar
- Hanssen AM, Fossum A, Mikalsen J, Halvorsen DS, Bukholm G, Sollid JU. Dissemination of community-acquired methicillin-resistant Staphylococcus aureus clones in northern Norway: sequence types 8 and 80 predominate. J Clin Microbiol. 2005;43:2118–24. DOIPubMedGoogle Scholar
- Chini V, Petinaki E, Foka A, Paratiras S, Dimitracopoulos G, Spiliopoulou I. Spread of Staphylococcus aureus clinical isolates carrying Panton-Valentine leukocidin genes during a 3-year period in Greece. Clin Microbiol Infect. 2006;12:29–34. DOIPubMedGoogle Scholar
- Wang CC, Lo WT, Chu ML, Siu LK. Epidemiological typing of community-acquired methicillin-resistant Staphylococcus aureus isolates from children in Taiwan. Clin Infect Dis. 2004;39:481–7. DOIPubMedGoogle Scholar
- Holmes A, Ganner M, McGuane S, Pitt TL, Cookson BD, Kearns AM. Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol. 2005;43:2384–90. DOIPubMedGoogle Scholar
- Salmenlinna S, Lyytikainen O, Vuopio-Varkila J. Community-acquired methicillin-resistant Staphylococcus aureus, Finland. Emerg Infect Dis. 2002;8:602–7.PubMedGoogle Scholar
- Harbarth S, Francois P, Shrenzel J, Fankhauser-Rodriguez C, Hugonnet S, Koessler T, Community-associated methicillin-resistant Staphylococcus aureus, Switzerland. Emerg Infect Dis. 2005;11:962–5.PubMedGoogle Scholar
- Krzyszton-Russjan J, Tambic-Andrasevic A, Bukovski S, Sabat A, Hryniewicz W. First community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strains in Croatia. Clin Microbiol Infect. 2006;12:697–8. DOIPubMedGoogle Scholar
- Miklasevics E, Haeggman S, Balode A, Sanchez B, Martinsons A, Olsson-Liljequist B, Report on the first PVL-positive community acquired MRSA strain in Latvia. Euro Surveill. 2004;9:29–30.PubMedGoogle Scholar
- Ribeiro A, Dias C, Silva-Carvalho MC, Berquo L, Ferreira FA, Santos RN, First report of infection with community-acquired methicillin-resistant Staphylococcus aureus in South America. J Clin Microbiol. 2005;43:1985–8. DOIPubMedGoogle Scholar
- Ma XX, Galiana A, Pedreira W, Mowszowicz M, Christophersen I, Machiavello S, Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay. Emerg Infect Dis. 2005;11:973–6.PubMedGoogle Scholar
- Mulvey MR, MacDougall L, Cholin B, Horsman G, Fidyk M, Woods S. Community-associated methicillin-resistant Staphylococcus aureus, Canada. Emerg Infect Dis. 2005;11:844–50.PubMedGoogle Scholar
- Otsuka T, Saito K, Dohmae S, Takano T, Higuchi W, Takizawa Y, Key adhesin gene in community-acquired methicillin-resistant Staphylococcus aureus. Biochem Biophys Res Commun. 2006;346:1234–44. DOIPubMedGoogle Scholar
- Seybold U, Kourbatova EV, Johnson JG, Halvosa SJ, Wang YF, King MD, Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care–associated blood stream infections. Clin Infect Dis. 2006;42:647–56. DOIPubMedGoogle Scholar
- Kourbatova EV, Halvosa JS, King MD, Ray SM, White N, Blumberg HM. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA 300 clone as a cause of health care–associated infections among patients with prosthetic joint infections. Am J Infect Control. 2005;33:385–91. DOIPubMedGoogle Scholar
- Ramdani-Bouguessa N, Bes M, Meugnier H, Forey F, Reverdy ME, Lina G, Detection of methicillin-resistant Staphylococcus aureus strains resistant to multiple antibiotics and carrying the Panton-Valentine leukocidin genes in an Algiers hospital. Antimicrob Agents Chemother. 2006;50:1083–5. DOIPubMedGoogle Scholar
- Maier J, Melzl H, Reischl U, Drubel I, Witte W, Lehn N, H. Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Germany associated with travel or foreign family origin. Eur J Clin Microbiol Infect Dis. 2005;24:637–9. DOIPubMedGoogle Scholar
- Gillet Y, Issartel B, Vanhems P, Fournet JC, Lina G, Bes M, Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002;359:753–9. DOIPubMedGoogle Scholar
- Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, Welty D, Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis. 2006;194:1761–70. DOIPubMedGoogle Scholar