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Volume 13, Number 5—May 2007
Dispatch

Avian Influenza (H5N1) Virus in Waterfowl and Chickens, Central China

Zhengjun Yu*1, Yunfeng Song*1, Hongbo Zhou*, Xiaojuan Xu*, Qiaoyun Hu*, Haiya Wu*, Anding Zhang*, Yanjun Zhou*, Jianfeng Chen*, Hanbing Dan*, Qingping Luo*, Xiangmin Li*, Huanchun Chen*, and Meilin Jin*Comments to Author 

Author affiliations: *Huazhong Agricultural University, Wuhan, People’s Republic of China;

Main Article

Table 1

Characteristics of the 7 avian influenza (H5N1) isolates obtained in central People’s Republic of China, 2004*

HA titers Avian
 Mammalian
EID50 IVPI ICPI Pathogenicity in chickens† TCID50 MLD50 Pathotype in mice‡
EWHC
 210
 107.5
 3.0
 1.91
 High
 104.41
 101.3
 High
CKDW
 28
 108.23
 3.0
 1.78
 High
 107.8
 102.3
 High
GOZF
 28
 109.8
 2.98
 1.88
 High
 107.35
 101.5
 High
CKXF
 28
 106.22
 2.96
 1.88
 High
 104.67
 106
 Medium
CKJZ
 28
 106.33
 3.0
 1.9
 High
 105.24
 >106.5
 Low
CKTM
 28
 107.23
 1.71
 1.36
 High
 102.0
 >106.5
 Low
DKXF 28 106.67 0 1.25 Low 106.57 >106.5 None

*HA, hemagglutinin; EID50, 50% egg infectious dose; IVPI, intravenous pathogenicity index; ICPI, intracerebral pathogenicity index; TCID50, 50% tissue culture infectious dose;; MLD50, 50% lethal dose in mice; EWHC, A/widgeon/Hubei/EWHC/2004; CKDW, A/chicken/Hubei/327/2004; GOZF, A/goose/Hubei/ZFE/2004; CKXF, A/chicken/Hubei/XFJ/2004; CKJZ, A/chicken/Hubei/JZJ/2004; CKTM, A/chicken/Hubei/TMJ/2004; DKXF, A/duck/Hubei/XFY/2004.
†Avian influenza virus isolates are considered to be highly pathogenic if they cause a death rate of >75% within 10 days or have an IVPI of >1.2 (World Organization for Animal Health criteria).
‡The pathotypes in mice were divided into none, low (MLD50>6.5 log10EID50), medium (3.0 log10EID50<MLD50≤6.5 log10EID50), and high (MLD50≤3.0 log10EID50).

Main Article

1Contributed equally to this article.

Page created: June 23, 2010
Page updated: June 23, 2010
Page reviewed: June 23, 2010
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