Volume 13, Number 7—July 2007
Research
Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom
Verena Schneider-Lindner*†, J. A. Delaney*†, Sandra Dial†‡, Andre Dascal‡, and Samy Suissa*†
Table 3
Risk for infection with community-acquired methicillin-resistant Staphylococcus aureus (MRSA)*
| Class of antimicrobial drug | Case-patients (N = 1,981), no. (%) | Control-patients (N = 19,779), no. (%) | Crude OR | Adjusted OR† | 95% CI |
|---|---|---|---|---|---|
| No prescription (reference group) | 770 (38.9) | 12,821 (64.8) | 1 | 1 | |
| Cephalosporins | 27 13.6 () | 994 (5.0) | 2.01 | 1.85 | 1.57–2.19 |
| Macrolides | 32 (16.2) | 1,04 (5.2) | 2.70 | 2.50 | 2.14–2.91 |
| Penicillins | 540 (27.3) | 3,104 (15.7) | 1.67 | 1.56 | 1.39–1.76 |
| Other antimicrobial drugs | 204 (10.3) | 1,615 (8.1) | 2.02 | 1.90 | 1.61–2.24 |
| Sulfonamides | 260 (13.1) | 1,114 (5.8) | 1.77 | 1.74 | 1.48–2.04 |
| Tetracyclines | 77 (3.9) | 461 (2.3) | 1.14 | 1.09 | 0.83–1.43 |
| Quinolones | 218 (11.0) | 434 (2.2) | 3.81 | 3.37 | 2.80–4.09 |
*For persons prescribed different classes of antimicrobial drugs in the 30–365 days before their index date, relative to risk for MRSA infection in persons with no prescriptions during the same period. Data from General Practice Research Database, United Kingdom, 2000–2004. OR, odds ratio; CI, confidence interval.
†Adjusted for prescriptions from other antimicrobial drug classes in the 30–365 days before the index date and all variables in Table 1.
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