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Volume 13, Number 9—September 2007

Parenteral Transmission of the Novel Human Parvovirus PARV4

Peter Simmonds*Comments to Author , Ashleigh Manning*, Rachel Kenneil*, Frances W. Carnie†, and Jeanne E. Bell†
Author affiliations: *University of Edinburgh, Edinburgh, Scotland, United Kingdom; †Western General Hospital, Edinburgh, Scotland, United Kingdom;

Main Article

Table 1

Detection of parvovirus B19 and PARV4 in study groups*

Participant category (no.) M/F Age at death, y (range)† Year of death (range)† Mean CD4/μL (range)† AIDS? B19 positive, 
no. (%) PARV4 positive, no. (%)
HIV+ IDU, AIDS‡ (13) 10/3 35 (2–48) 1995 
(1991–1998) 44 
(1–137) Y 6 (46) 11 (85)
HIV+ IDU, pre-AIDS‡ (11) 7/4 33 (29–40) 1996 (1992–1998) 268 
(167–496) N 6 (55) 6 (55)
HIV+ MSM (13) 13/0 39 (28–49) 1993 (1990–1996) 25 
(1–160) Y 7 (54) 0
HIV– IDU (12) 10/2 35 (24–49) 1999 (1992–2005) ND NA 8 (67) 1 (8)
Hemophilia (2) 2/0 22, 26 1994, 1995 0 Y 0 1 (50)
Low-risk control§ (8) 3/5 54 (28–89) All 2005 ND NA 8 (100) 0

*IDU, injection drug user; M, male; F, female; Y, yes; N, no; MSM, men who had sex with men; ND, not done; NA, not applicable.
†Values are means (ranges) or individual values for those with hemophilia.
‡These study groups overlap with the previously analyzed HIV-positive group (8), restricted to those in whom parenteral risk factors for infection have been identified.
§Previously described in (8).

Main Article

  1. Jones  MS, Kapoor  A, Lukashov  VV, Simmonds  P, Hecht  F, Delwart  E. New DNA viruses identified in patients with acute viral infection syndrome. J Virol. 2005;79:82306. DOIPubMed
  2. Fryer  JF, Kapoor  A, Minor  PD, Delwart  E, Baylis  SA. Novel parvovirus and related variant in human plasma. Emerg Infect Dis. 2006;12:1514.PubMed
  3. Fryer  JF, Delwart  E, Hecht  FM, Bernardin  F, Jones  MS, Shah  N, Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals. Transfusion. 2007;47:105461. DOIPubMed
  4. Fryer  JF, Lucas  SB, Padley  D, Baylis  SA. Parvoviruses PARV4/5 in hepatitis C virus–infected patient. Emerg Infect Dis. 2007;13:1756. DOIPubMed
  5. Soderlund-Venermo  M, Hokynar  K, Nieminen  J, Rautakorpi  H, Hedman  K. Persistence of human parvovirus B19 in human tissues. Pathol Biol (Paris). 2002;50:30716. DOIPubMed
  6. Norja  P, Hokynar  K, Aaltonen  LM, Chen  R, Ranki  A, Partio  EK, Bioportfolio: lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue. Proc Natl Acad Sci U S A. 2006;103:74503. DOIPubMed
  7. Isa  A, Kasprowicz  V, Norbeck  O, Loughry  A, Jeffery  K, Broliden  K, Prolonged activation of virus-specific CD8+T cells after acute B19 infection. PLoS Med. 2005;2:e343. DOIPubMed
  8. Manning  A, Willey  SJ, Bell  JE, Simmonds  P. Tissue distribution, persistence and molecular epidemiology of parvovirus B19 and novel human parvoviruses, PARV4 and human bocavirus. J Infect Dis. 2007;195:134552. DOIPubMed
  9. Vyse  AJ, Andrews  NJ, Hesketh  LM, Pebody  R. The burden of parvovirus B19 infection in women of childbearing age in England and Wales. Epidemiol Infect. 2007; 19.
  10. Hagan  H, Des  J. HIV and HCV infection among injecting drug users. Mt Sinai J Med. 2000;67:4238.PubMed
  11. Allander  T, Tammi  MT, Eriksson  M, Bjerkner  A, Tiveljung-Lindell  A, Andersson  B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A. 2005;102:128916. DOIPubMed

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