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Volume 14, Number 1—January 2008
Letter

Antimicrobial Drug Use and Antibiotic-Resistant Bacteria

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To the Editor

The article by Harris et al., published in the August 2007 issue of Emerging Infectious Diseases, examined the risk factors for selecting extended-spectrum β-lactamase–producing Enterobacteriaceae in intensive-care patients and found that exposure to piperacillin/tazobactam and vancomycin were independent risk factors (1). Although antimicrobial drug use has been historically linked to antibiotic resistance in bacteria, we should not miss the perspective that such a risk factor mostly favors the cross-transmission of preexisting antibiotic-resistant bacteria, taking into account the disruption of the endogenous microflora, rather than the selection of “de novo” resistant mutants (2). This supposition is supported by many articles that have found genetic similarity between antibiotic-resistant microorganisms that occur in hospitalized patients, as well as by the fact that most of these pathogens exhibit cross-resistance with different classes of drugs, which should be extremely rare on a mutation basis.

This hypothesis is also supported by the evidence that healthcare workers frequently do not obey simple infection control precautions such as practicing hand hygiene between contact with different patients (36). That is likely why Larson et al., in a multicenter study in the United States, recently found no relationship between antimicrobial drug control policies and level of antibiotic resistance in bacteria, but did find an association between lower levels of antibiotic resistance in Staphylococcus aureus and enterococci and high compliance with hand hygiene (7).

Therefore, perhaps we should start looking for risk factors for being colonized or infected by any antimicrobial drug–resistant bacterium, including in our analysis some infection control measures adopted commonly during outbreak investigations, such as exposure to doctor A or nurse B, proximity to a known colonized patient, understaffing during the period of the study, and so forth. If we do so, we will likely find that antimicrobial drug use is not a completely independent risk factor for the mentioned outcome, but a risk factor closely related to the availability of the antibiotic-resistant microorganism in the local environment or on our own hands.

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Fernando Bellissimo-Rodrigues*Comments to Author 

Author affiliation: *Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, São Paulo, Brazil

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References

  1. Harris  AD, McGregor  JC, Johnson  JA, Strauss  SM, Moore  AC, Standiford  HC, Risk factors for colonization with extended-spectrum β-lactamase–producing bacteria and intensive care unit admission. Emerg Infect Dis. 2007;13:11449.PubMed
  2. Lipsitch  M, Samore  MH. Antimicrobial use and antimicrobial resistance: a population perspective. Emerg Infect Dis. 2002;8:34754.PubMed
  3. Gupta  A, Della-Latta  P, Todd  B, San Gabriel  P, Haas  J, Wu  F, Outbreak of extended-spectrum beta-lactamase–producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails. Infect Control Hosp Epidemiol. 2004;25:2105. DOIPubMed
  4. Zanetti  G, Blanc  DS, Federli  I, Raffoul  W, Petignat  C, Maravic  P, Importation of Acinetobacter baumannii into a burn unit: a recurrent outbreak of infection associated with widespread environmental contamination. Infect Control Hosp Epidemiol. 2007;28:7235. DOIPubMed
  5. Bratu  S, Mooty  M, Nichani  S, Landman  D, Gullans  C, Pettinato  B, Emergence of KPC-possesing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection. Antimicrob Agents Chemother. 2005;49:301820. DOIPubMed
  6. Pittet  D, Hugonnet  S, Harbarth  S, Mourouga  P, Sauvan  V, Touveneau  S, Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet. 2000;356:130712. DOIPubMed
  7. Larson  EL, Quiros  D, Giblin  T, Lin  S. Relationship of antimicrobial control policies and hospital characteristics to antimicrobial resistance rates. Am J Crit Care. 2007;16:1109.PubMed

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Cite This Article

DOI: 10.3201/eid1401.071028

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Table of Contents – Volume 14, Number 1—January 2008

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Fernando Bellissimo-Rodrigues, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (USP), Av dos Bandeirantes 3900, CEP 14048-900, Ribeirão Preto, SP, Brazil;

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Page created: July 08, 2010
Page updated: July 08, 2010
Page reviewed: July 08, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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