Volume 14, Number 3—March 2008
Research
Multicenter Cross-Sectional Study of Nontuberculous Mycobacterial Infections among Cystic Fibrosis Patients, Israel
Isaac Levy*1, Galia Grisaru-Soen*12, Liat Lerner-Geva†, Eitan Kerem‡, Hana Blau§, Lea Bentur¶, Micha Aviram#, Joseph Rivlin**, Elie Picard††, Anita Lavy‡‡, Yakov Yahav*, and Galia Rahav*
Table 3
Comparison of patients and controls in univariate and multivariate analyses*
| Parameter | Patients (n = 42) | Controls (n = 144) | p value | Adjusted OR | 95% CI |
|---|---|---|---|---|---|
| Age, y (mean ± SD) | 24.2 ± 10.9 | 19.4 ± 10.0 | 0.014 | 1.03 | 0.99–1.09 |
| Sex, F/M | 18/24 | 56/88 | 0.64 | ||
| No. sputum specimens (mean ± SD) | 5.7 ± 4.8 | 2.4 ± 1.7 | <0.0001 | 1.47 | 1.17–1.85 |
| Hemoptysis | 10 | 12 | 0.006 | 1.08 | 0.29–4.05 |
| FEV1, L/s (mean ± SD) | 56.7 ± 19.6 | 71.2 ± 21.8 | 0.0001 | 0.97 | 0.94–0.99 |
| Pancreatic insufficiency | 35 | 100 | 0.07 | ||
| Sweat chloride, Meq/ L (mean ± SD) | 73.1 ± 50.2 | 66.2 ± 48.3 | 0.43 | ||
| Hospitalization, d (mean ± SD) | 33.2 ± 37.5 | 18.4 ± 24.5 | 0.019 | 0.99 | 0.97–1.01 |
| Administration of antimicrobial drugs, d (mean ± SD) | 49.9 ± 78.7 | 14.7 ± 29.4 | 0.007 | 0.99 | 0.98–1.00 |
| Azithromycin treatment | 30 | 74 | 0.02 | 1.00 | 0.99–1.00 |
| Azithromycin treatment, d (mean ± SD) | 367.6 ± 302.7 | 221.9 ± 288.4 | 0.007 | 1.00 | 0.99–1.00 |
| Ibuprofen treatment | 5 | 2 | 0.001 | 4.72 | 0.60–36.85 |
| Insulin treatment | 4 | 13 | 0.92 | ||
| Systemic steroids treatment | 3 | 10 | 0.96 | ||
| Inhaled steroids treatment | 26 | 70 | 0.13 | ||
| Pseudomonas aeruginosa | 40 | 94 | 0.0005 | 0.76 | 0.32–1.79 |
| Staphylococcus aureus | 18 | 58 | 0.95 | ||
| Aspergillus spp. | 28 | 31 | <0.0001 | 5.14 | 1.87–14.11 |
| Allergic bronchopulmonary aspergillosis | 3 | 3 | 0.10 | ||
| Haemophillus influenza | 3 | 24 | 0.13 | ||
| Alcaligenes xylosoxidans | 0 | 5 | 0.22 | ||
| Klebsiella pneumoniae | 3 | 4 | 0.17 | ||
| Stenotrophomonas maltophilia | 2 | 3 | 0.34 |
*OR, odds ratio; CI, confidence interval; SD, standard deviation; FEV1, forced expiratory volume in 1 s.
1These authors contributed equally to this work.
2Current affiliation: Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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