Volume 14, Number 7—July 2008
Dispatch
Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases
Dana C. Crawford*, Shanta M. Zimmer†, Craig A. Morin‡, Nancy E. Messonnier§, Ruth Lynfield‡, Qian Yi¶, Cynthia Shephard¶, Michelle Wong¶, Mark J. Rieder¶, Robert J. Livingston¶, Deborah A. Nickerson¶, Cynthia G. Whitney§, and Jairam Lingappa¶
Table 2
Number of diallelic sites (SNPs) identified for CD46, by population*
| Population | Sample size | No. SNPs† (population-specific SNPs)‡ | No. common SNPs§ |
|---|---|---|---|
| European American | 23 | 93 (32) | 58 |
| African | 24 | 130 (74)¶ | 68 |
| Asian | 24 | 88 (30) | 46 |
| Hispanic | 6 | 56 (3) | 56 |
| Study samples | 66 | 173 (59) | 66 |
| Case-patients | 22 | 116 (27) | 70 |
| Controls | 44 | 146 (57) |
*SNPs, single nucleotide polymorphisms.
†Includes SNPs and diallelic insertion/deletion polymorphisms (indels).
‡No. SNPs identified in only that racial/ethnic population.
§Common SNPs defined as having a minor allele frequency >5%.
¶Two SNPs (sites 18924 and 28122) were specific to the African cohort but in regions not resequenced sufficiently in other populations. Additional genotyping is needed to conclusively identify these as African specific.
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