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Volume 14, Number 7—July 2008


Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases

Dana C. Crawford*, Shanta M. Zimmer†, Craig A. Morin‡, Nancy E. Messonnier§, Ruth Lynfield‡, Qian Yi¶, Cynthia Shephard¶, Michelle Wong¶, Mark J. Rieder¶, Robert J. Livingston¶, Deborah A. Nickerson¶, Cynthia G. Whitney§, and Jairam Lingappa¶Comments to Author 
Author affiliations: *Vanderbilt University, Nashville, Tennessee, USA; †Emory University, Atlanta, Georgia, USA; ‡Minnesota Department of Health, St. Paul, Minnesota, USA; §Centers for Disease Control and Prevention, Atlanta; ¶University of Washington, Seattle, Washington, USA;

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Table 2

Number of diallelic sites (SNPs) identified for CD46, by population*

Population Sample size No. SNPs† (population-specific SNPs)‡ No. common SNPs§
European American 23 93 (32) 58
African 24 130 (74)¶ 68
Asian 24 88 (30) 46
Hispanic 6 56 (3) 56
Study samples 66 173 (59) 66
Case-patients 22 116 (27) 70
Controls 44 146 (57)

*SNPs, single nucleotide polymorphisms.
†Includes SNPs and diallelic insertion/deletion polymorphisms (indels).
‡No. SNPs identified in only that racial/ethnic population.
§Common SNPs defined as having a minor allele frequency >5%.
¶Two SNPs (sites 18924 and 28122) were specific to the African cohort but in regions not resequenced sufficiently in other populations. Additional genotyping is needed to conclusively identify these as African specific.

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