Volume 14, Number 9—September 2008
Letter
Merkel Cell Polyomavirus and Merkel Cell Carcinoma, France
Vincent Foulongne
, Nicolas Kluger, Olivier Dereure, Natalie Brieu, Bernard Guillot, and Michel Segondy
, Nicolas Kluger, Olivier Dereure, Natalie Brieu, Bernard Guillot, and Michel Segondy
Table
Merkel cell polyomavirus from 9 patients with Merkel cell carcinoma and 15 control patients, France*
| Patient no. | Age, y | Sex | Diagnosis | Sample | PCR primer pair |
||
|---|---|---|---|---|---|---|---|
| LT1 | LT3 | VP1 | |||||
| 1 | 57 | M | MCC, primary | Fresh biopsy, buttock | + | + | + |
| 2 | 61 | F | MCC, primary | FFPE biopsy, buttock | – | + | – |
| 3 | 57 | F | MCC, primary | FFPE biopsy, lower eyelid | – | + | + |
| 4 | 82 | F | MCC, primary | FFPE biopsy, cheek | – | + | – |
| 5 | 78 | M | MCC, metastatic | Fresh biopsy, jugular lymph node | – | + | + |
| 6 | 80 | F | MCC, primary | Fresh biopsy, upper eyelid | – | + | + |
| 7 | 65 | M | MCC, primary | FFPE biopsy, temple | – | + | – |
| 8 | 81 | M | MCC, primary | FFPE biopsy, forearm | – | – | – |
| 9 | 60 | M | MCC, primary | FFPE biopsy, forearm | – | + | + |
| 10 | 61 | M | Hyperkeratosis | Fresh biopsy, foot | – | – | – |
| 11 | 49 | M | Seborrheic keratosis, penis | Fresh biopsy, penis shaft | – | – | – |
| 12 | 60 | M | Nonspecific lesion, esophagus | Fresh biopsy, lesion | – | – | – |
| 13 | 40 | M | Nasal papilloma | Fresh biopsy, papilloma | – | – | – |
| 14 | 58 | M | Anal condylomas | Fresh biopsy, condyloma | – | – | – |
| 15 | 44 | M | Epidermodysplasia verruciformis | Fresh biopsy, skin | – | – | – |
| 16 | 19 | M | Cutaneous warts | Fresh biopsy, wart | – | – | – |
| 17 | 57 | F | Cutaneous warts | Fresh biopsy, wart | – | – | – |
| 18 | 64 | F | Cutaneous nodule | Fresh biopsy, skin | – | – | – |
| 19 | 6 | F | Pharyngeal papillomatosis | Fresh biopsy, pharynx | – | – | – |
| 20 | 27 | M | Vocal cord polyp | Fresh biopsy, polyp | – | – | – |
| 21 | 58 | M | Lichen | Fresh biopsy, skin | – | – | – |
| 22 | 63 | M | Skin inflammation | Fresh biopsy, skin | – | – | – |
| 23 | 72 | M | Skin inflammation | Fresh biopsy, skin | – | – | – |
| 24 | 57 | M | Skin inflammation | Fresh biopsy, skin | – | – | – |
*MCC, Merkel cell carcinoma; +, positive Merkel cell polyomavirus PCR amplification; FFPE, formaldehyde-fixed paraffin-embedded; –, negative Merkel cell polyomavirus PCR amplification.
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