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Volume 15, Number 1—January 2009
Perspective

Threat of Dengue to Blood Safety in Dengue-Endemic Countries

Annelies Wilder-SmithComments to Author , Lin H. Chen, Eduardo Massad, and Mary E. Wilson
Author affiliations: National University Singapore, Singapore (A. Wilder-Smith); Harvard Medical School, Boston, Massachusetts, USA (L.H. Chen, M.E. Wilson); Harvard School of Public Health, Boston (M.E. Wilson); Mount Auburn Hospital, Cambridge, Massachusetts, USA (L.H. Chen, M.E. Wilson); University of São Paulo, São Paulo, Brazil (E. Massad)

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Table

Reported healthcare-associated transmission of flaviviruses

Virus Route of transmission Comment References
Dengue Percutaneous Several healthcare workers were infected after needlestick injuries during care of returned travelers who had diagnoses of dengue. (8,1013)
Mucocutaneous A healthcare worker became infected with dengue 3 virus after being splashed in the face by blood from a febrile traveler who had a diagnosis of dengue. (7,14)
Blood transfusion A 17-year-old man from Hong Kong, Special Administrative Region, People’s Republic of China, donated blood in July 2002, from which erythrocytes were transfused to a 72-year-old woman, in whom febrile illness consistent with dengue fever developed 3 d later. (15)
Bone marrow transplant A 6-year-old child from Puerto Rico became infected with dengue 4 virus from a bone marrow transplant and died. (16)

Renal transplant
Dengue hemorrhagic fever developed after a living donor renal transplant.
(17)
Yellow fever
Laboratory
A laboratory technician acquired yellow fever after obtaining blood and performing a blood count on a yellow fever patient; he died subsequently. Yellow fever was transmitted to at least 30 other scientists and laboratory workers after contact with mouse or monkey blood or tissues or handling infected animals.
(1820)
West Nile Percutaneous Virus was transmitted to 2 microbiologists by laceration or needlestick injuries in laboratory. (21)
Transfusion Virus was transmitted to numerous recipients of blood products. (22,23)
Organ transplant Virus was transmitted to transplant recipients from kidneys, liver, and heart of an infected donor. (24)
Hemodialysis Virus infection in a cluster of 3 hemodialysis patients suggested transmission through a common dialysis machine. (25)

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References
  1. Gubler  DJ. The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res. 2002;33:33042. DOIPubMed
  2. Wilder-Smith  A, Schwartz  E. Dengue in travelers. N Engl J Med. 2005;353:92432. DOIPubMed
  3. Gubler  DJ, Suharyono  W, Tan  R, Abidin  M, Sie  A. Viraemia in patients with naturally acquired dengue infection. Bull World Health Organ. 1981;59:62330.PubMed
  4. Burke  DS, Nisalak  A, Johnson  DE, Scott  RM. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg. 1988;38:17280.PubMed
  5. Sudiro  TM, Zivny  J, Ishiko  H, Green  S, Vaughn  DW, Kalayanarooj  S, Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor reverse transcription-polymerase chain reaction. J Med Virol. 2001;63:2934. DOIPubMed
  6. Dengue virus transfusion transmission—China (Hong Kong) [cited 2008 Oct 1]. Available from http://www.slu.edu/colleges/sph/csbei/emerginginfections/dengue/news/dengue101102a.pdf
  7. Chen  LH, Wilson  ME. Nosocomial dengue by mucocutaneous transmission. Emerg Infect Dis. 2005;11:775.PubMed
  8. de Wazieres  B, Gil  H, Vuitton  DA, Dupond  JL. Nosocomial transmission of dengue from a needlestick injury. Lancet. 1998;351:498. DOIPubMed
  9. Chen  L, Wilson  ME. Non-vector transmission of dengue and other mosquito borne flaviviruses. Dengue Bull. 2005;29:1831.
  10. Nemes  Z, Kiss  G, Madarassi  EP, Peterfi  Z, Ferenczi  E, Bakonyi  T, Nosocomial transmission of dengue. Emerg Infect Dis. 2004;10:18801.PubMed
  11. Hirsch  JF, Deschamps  C, Lhuillier  M. Metropolitan transmission of dengue by accidental inoculation at a hospital [in French]. Ann Med Interne (Paris). 1990;141:629.PubMed
  12. Langgartner  J, Audebert  F, Scholmerich  J, Gluck  T. Dengue virus infection transmitted by needle stick injury. J Infect. 2002;44:26970. DOIPubMed
  13. Wagner  D, de With  K, Huzly  D, Hufert  F, Weidmann  M, Breisinger  S, Nosocomial acquisition of dengue. Emerg Infect Dis. 2004;10:18723.PubMed
  14. Chen  LH, Wilson  ME. Transmission of dengue virus without a mosquito vector: nosocomial mucocutaneous transmission and other routes of transmission. Clin Infect Dis. 2004;39:e5660. DOIPubMed
  15. Lin  C. First documented case of transfusion transmitted dengue virus infection. ProMed [cited 2008 Oct 1]. Available from http://nrl.gov.au/hosting/serology/NRLAttach.nsf/Images
  16. Rigau-Perez  JG, Vorndam  AV, Clark  GG. The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994–1995. Am J Trop Med Hyg. 2001;64:6774.PubMed
  17. Tan  FL, Loh  DL, Prabhakaran  K, Tambyah  PA, Yap  HK. Dengue haemorrhagic fever after living donor renal transplantation. Nephrol Dial Transplant. 2005;20:4478. DOIPubMed
  18. Low  C, Fairley  NH. Laboratory and hospital infections with yellow fever in England. BMJ. 1931;2:1258.
  19. Berry  G, Kitchen  S. Yellow fever accidentally contracted in the laboratory: a study of seven cases. Am J Trop Med. 1931;11:365434.
  20. Cook  GC. Fatal yellow fever contracted at the Hospital for Tropical Diseases, London, in 1930. Trans R Soc Trop Med Hyg. 1994;88:7123. DOIPubMed
  21. Centers for Disease Control and Prevention. Laboratory-acquired West Nile virus infections—United States, 2002. MMWR Morb Mortal Wkly Rep. 2002;51:11335.PubMed
  22. Centers for Disease Control and Prevention. Update: West Nile virus screening of blood donations and transfusion-associated transmission—United States, 2003. MMWR Morb Mortal Wkly Rep. 2004;53:2814.PubMed
  23. Pealer  LN, Marfin  AA, Petersen  LR, Lanciotti  RS, Page  PL, Stramer  SL, Transmission of West Nile virus through blood transfusion in the United States in 2002. N Engl J Med. 2003;349:123645. DOIPubMed
  24. Iwamoto  M, Jernigan  DB, Guasch  A, Trepka  MJ, Blackmore  CG, Hellinger  WC, Transmission of West Nile virus from an organ donor to four transplant recipients. N Engl J Med. 2003;348:2196203. DOIPubMed
  25. Centers for Disease Control and Prevention. Possible dialysis-related West Nile virus transmission—Georgia, 2003. MMWR Morb Mortal Wkly Rep. 2004;53:7389.PubMed
  26. Komar  N. West Nile virus: epidemiology and ecology in North America. Adv Virus Res. 2003;61:185234. DOIPubMed
  27. Mostashari  F, Bunning  ML, Kitsutani  PT, Singer  DA, Nash  D, Cooper  MJ, Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey. Lancet. 2001;358:2614. DOIPubMed
  28. Biggerstaff  BJ, Petersen  LR. Estimated risk of West Nile virus transmission through blood transfusion during an epidemic in Queens, New York City. Transfusion. 2002;42:101926. DOIPubMed
  29. Ludlam  CA, Powderly  WG, Bozzette  S, Diamond  S, Koerper  MA, Kulkarni  R, Clinical perspectives of emerging pathogens in bleeding disorders. Lancet. 2006;367:25261. DOIPubMed
  30. Hamish  M, Stramer  S, Tomashek  K, Muñoz  J. Linnen, J, Petersen L. Prevalence of dengue virus nucleic acid in blood products donated in Puerto Rico. 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene; 2007 Nov 4–8: Philadelphia. Abstract 348.
  31. Linnen  JB, Collins  A, Cary  C, Kolk  JDP. Detection of dengue virus RNA in blood donors from Honduras and Brazil with a prototype transcription-mediated amplification assay. Annual Meeting of the American Association of Blood Banks; 2006 Oct 21–24: Miami. Abstracts. p. 11.
  32. Wilder-Smith  A, Foo  W, Earnest  A, Sremulanathan  S, Paton  NI. Seroepidemiology of dengue in the adult population of Singapore. Trop Med Int Health. 2004;9:3058. DOIPubMed
  33. Burattini  MN, Chen  M, Chow  A, Coutinho  FA, Goh  KT, Lopez  LF, Modelling the control strategies against dengue in Singapore. Epidemiol Infect. 2008;136:30919. DOIPubMed
  34. Tambyah  PA, Koay  ES, Poon  ML, Lin  RV, Ong  BK; Transfusion-Transmitted Dengue Infection Study Group. Dengue hemorrhagic fever transmitted by blood transfusion. N Engl J Med. 2008;359:15267. DOIPubMed
  35. Vaughn  DW, Green  S, Kalayanarooj  S, Innis  BL, Nimmannitya  S, Suntayakorn  S, Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181:29. DOIPubMed
  36. Busch  MP, Caglioti  S, Robertson  EF, McAuley  JD, Tobler  LH, Kamel  H, Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing. N Engl J Med. 2005;353:4607. DOIPubMed

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