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Volume 15, Number 12—December 2009


CTX-M β-Lactamase Production and Virulence of Escherichia coli K1

Damien Dubois, Nemani V. Prasadarao, Rahul Mittal, Laurent Bret, Marie Roujou-Gris, and Richard BonnetComments to Author 
Author affiliations: University of Auvergne, Clermont-Ferrand, France (D. Dubois, R. Bonnet); Teaching Hospital, Clermont-Ferrand (D. Dubois, R. Bonnet); Childrens Hospital, Los Angeles, California, USA (N.V. Prasadarao, R. Mittal); University of Southern California, Los Angeles (N.V. Prasadarao); La Source Hospital, Orléans, France (L. Bret, M. Roujou-Gris)

Main Article

Table 2

Incidence of meningitis in a newborn mouse model by Escherichia coli strain, France*

Bacterial strain No. animals Mean ± SD bacteremia, log CFU/mL blood No. positive CSF cultures (% meningitis)
E44 20 6.95 ± 0.6 17 (85)†
Orl-1 16 6.75 ± 0.8 16 (100)†
Orl-c 17 6.60 ± 0.5 14 (82)†
DH5α-CTX-M1 10 0.10 ± 0.1 0

*CSF, cerebrospinal fluid.
†p<0.005, significantly higher than the incidence of meningitis by DH5α-CTX-M1 by χ2 test.

Main Article