Volume 15, Number 3—March 2009
Dispatch
Human Bocavirus and KI/WU Polyomaviruses in Pediatric Intensive Care Patients
, Tom F.W. Wolfs, Nicolaas J.G. Jansen, Jan L.L. Kimpen, Anton M. van Loon, and John W.A. Rossen
Table 2
Clinical characteristics of PICU patients with LRTIs and of PICU controls whose samples tested positive for HBoV, KIPyV, or WUPyV infections, the Netherlands, 2005–2008*
| Patient no. | Diagnosis | Virus (Ct value) | Sample type | Sex | Age, mo | Immunocompromised | Other underlying disease | Length of stay, d | Other viruses |
|---|---|---|---|---|---|---|---|---|---|
| LRTI group | |||||||||
| 1 | LRTI | HBoV (39.4) | NPA | F | 13 | No | Pulmonary dysplasia (home mechanical ventilation) | 10 | Adeno, hMPV |
| 2 | LRTI | HBoV (15.0) | NPA | F | 9 | No | IRDS, PVL | 10 | Adeno |
| 3 | LRTI | HBoV (16.6) | NPA | M | 13 | No | Recurrent wheezing | 5 | RSV |
| 4 | LRTI | HBoV (15.0) | NPA | F | 19 | No | IRDS | 7 | None |
| 5 | LRTI | WUPyV (19.6) | NPA | M | 1 | No | None | 11 | RSV |
| 6 |
LRTI |
WUPyV (34.1) |
NPA |
F |
41 |
No |
Mitochondrial encephalopathy |
18 |
Influenza |
| Control group | |||||||||
| 7 | Sepsis | HBoV (36.5) | NPA | F | 27 | No | None | 7 | NA |
| 8 | Infectious meningitis | HBoV (34.7) | NPA | F | 100 | No | 22Q11 deletion (cardiac and neurologic disease) | 3 | NA |
| 9 | URTI | HBoV (37.9) | NPA | M | 41 | No | Spinal muscular atrophy | 74 | NA |
| 10 | Observation after brain biopsy | HBoV/ KIPyV (32/39) | NPA | F | 127 | Yes | AML, BMT, Brochiolitis obliterans | 46 | NA |
| 11 | VSD closure | WUPyV (33.8) | Throat swab | F | 15 | No | VSD | 2 | NA |
| 12 | Septic shock | WUPyV (34.4) | NPA | M | 40 | No | None | 19 | NA |
| 13 | Cardiac malformation | KIPyV (34.1) | NPA | F | 4 | No | Cardiac malformation | 14 | NA |
| 14 | Septic shock | KIPyV (23.1) | NPA | M | 152 | Yes | AML, aplasia | 11 | NA |
| 15 | ALTE | KIPyV (26.7) | NPA | M | 2 | No | None | 8 | NA |
*PICU, Pediatric Intensive Care Unit, Wilhelmina Children’s Hospital, University Medical Center Utrecht, the Netherlands; LRTI, lower respiratory tract infection; HBoV, human bocavirus; KIPyV, KI polyomavirus; WUPyV, WU polyomavirus; Ct, cycle threshold; NPA, nasopharyngeal aspirate; Adeno, adenovirus; hMPV, human metapneumovirus; RSV, respiratory syncytial virus; IRDS, idiopathic respiratory distress syndrome; PVL, periventricular leukomalacia; NA, not assessed; URTI, upper respiratory tract infection; AML, acute myeloid leukemia; BMT, bone marrow transplant; VSD, ventricular septal defect; ALTE, apparent life-threatening event.