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Volume 15, Number 3—March 2009


Human Bocavirus and KI/WU Polyomaviruses in Pediatric Intensive Care Patients

Alma C. van de PolComments to Author , Tom F.W. Wolfs, Nicolaas J.G. Jansen, Jan L.L. Kimpen, Anton M. van Loon, and John W.A. Rossen
Author affiliations: University Medical Center Utrecht, Utrecht, the Netherlands (A.C. van de Pol, T.F.W. Wolfs, N.J.G. Jansen, J.L.L. Kimpen, A.M. van Loon, J.W.A Rossen); St. Elisabeth Hospital Tilburg, Tilburg, the Netherlands (J.W.A. Rossen)

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Table 2

Clinical characteristics of PICU patients with LRTIs and of PICU controls whose samples tested positive for HBoV, KIPyV, or WUPyV infections, the Netherlands, 2005–2008*

Patient no. Diagnosis Virus 
(Ct value) Sample type Sex Age, mo Immunocompromised Other underlying disease Length of stay, d Other viruses
LRTI group
1 LRTI HBoV (39.4) NPA F 13 No Pulmonary dysplasia (home mechanical ventilation) 10 Adeno, hMPV
2 LRTI HBoV (15.0) NPA F 9 No IRDS, PVL 10 Adeno
3 LRTI HBoV (16.6) NPA M 13 No Recurrent wheezing 5 RSV
4 LRTI HBoV (15.0) NPA F 19 No IRDS 7 None
5 LRTI WUPyV (19.6) NPA M 1 No None 11 RSV
WUPyV (34.1)
Mitochondrial encephalopathy
Control group
7 Sepsis HBoV (36.5) NPA F 27 No None 7 NA
8 Infectious meningitis HBoV (34.7) NPA F 100 No 22Q11 deletion (cardiac and neurologic disease) 3 NA
9 URTI HBoV (37.9) NPA M 41 No Spinal muscular atrophy 74 NA
10 Observation after brain biopsy HBoV/ KIPyV (32/39) NPA F 127 Yes AML, BMT, Brochiolitis obliterans 46 NA
11 VSD closure WUPyV (33.8) Throat swab F 15 No VSD 2 NA
12 Septic shock WUPyV (34.4) NPA M 40 No None 19 NA
13 Cardiac malformation KIPyV (34.1) NPA F 4 No Cardiac malformation 14 NA
14 Septic shock KIPyV (23.1) NPA M 152 Yes AML, aplasia 11 NA
15 ALTE KIPyV (26.7) NPA M 2 No None 8 NA

*PICU, Pediatric Intensive Care Unit, Wilhelmina Children’s Hospital, University Medical Center Utrecht, the Netherlands; LRTI, lower respiratory tract infection; HBoV, human bocavirus; KIPyV, KI polyomavirus; WUPyV, WU polyomavirus; Ct, cycle threshold; NPA, nasopharyngeal aspirate; Adeno, adenovirus; hMPV, human metapneumovirus; RSV, respiratory syncytial virus; IRDS, idiopathic respiratory distress syndrome; PVL, periventricular leukomalacia; NA, not assessed; URTI, upper respiratory tract infection; AML, acute myeloid leukemia; BMT, bone marrow transplant; VSD, ventricular septal defect; ALTE, apparent life-threatening event.

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