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Volume 15, Number 5—May 2009


Cross-Border Dissemination of Methicillin-Resistant Staphylococcus aureus, Euregio Meuse-Rhin Region

Ruud H. DeurenbergComments to Author , Eric Nulens, Havard Valvatne, Silvie Sebastian, Christel Driessen, Jos Craeghs, Els De Brauwer, Bernhard Heising, Yvette J. Kraat, Joachim Riebe, Frans S. Stals, Thera A. Trienekens, Jacques Scheres, Alexander W. Friedrich, Frank H. Van Tiel, Patrick S. Beisser, and Ellen E. Stobberingh
Author affiliations: University Hospital Maastricht, Maastricht, the Netherlands (R.H. Deurenberg, H. Valvatne, S. Sebastian, C. Driessen, J. Scheres, F.H. van Tiel, P.S. Beisser, E.E. Stobberingh); General Hospital Sint-Jan, Brugge, Belgium (E. Nulens); General Hospital Vesalius, Tongeren, Belgium (J. Craeghs); Atrium Medical Center, Heerlen, the Netherlands (E. De Brauwer); General Hospital Düren, Düren, Germany (B. Heising); Orbis Medical and Care Center, Sittard, the Netherlands (Y.J. Kraat); Laboratory Aachen, Aachen, Germany (J. Riebe); Laurentius Hospital, Roermond, the Netherlands (F.S. Stals); VieCuri Medical Center, Venlo, the Netherlands (T.A. Trienekens); University of Münster, Münster, Germany (A.W. Friedrich)

Main Article

Table 2

Composition of the spa-CCs of 257 MRSA isolates in the Euregio Meuse-Rhin region, July 2005–April 2006*

spa-CC No. (%) isolates No. (%) 
spa types spa types ST CC
045 134 (52) 9 (25) t002, t003, t041, t045, t179, t447, t504, t838, t1107 ST5/ST225† CC5
019/012/318/011/108 19 (7) 7 (19) t011, t012, t019, t034, t108, t318, t582 ST36/ST398‡ CC30/CC398
038 58 (22) 5 (14) t038, t161, t740, t1288, t1310 ST45 CC45
044/042 4 (2) 4 (11) t042, t044, t131, t345 ST728/ST772§ CC1/CC80
No founder 5 22 (9) 2 (6) t008, t622 ST8 CC8
No founder 6 8 (3) 2 (6) t040, t553 ST45 CC45
Singletons 8 (3) 4 (11) t223, t375, t682, t786 ST217¶ CC22/CC89
Excluded# 4 (2) 3 (8) t457, t779, t1011
Total 257 (100) 36 (100)

*CC, clonal complex; MRSA, methicillin-resistant Staphylococcus aureus; ST, sequence type. Boldface indicates spa types on which multilocus sequence typing analysis was performed.
†The strains spa typed as t003 and t045 had ST225, a single-locus variant of ST5 at the tpi locus. The strain spa typed as t447 had ST5.
‡The strain spa typed as t011 had ST398, and the strain spa typed as t012 had ST36.
§The strain spa typed as t044 had ST728, a single-locus variant of ST80 at the tpi locus. The strain spa typed as t345 had ST772, a single-locus variant of ST1 at the pta locus.
¶The strain spa typed as t223 had ST217, a single-locus variant of ST22 at the tpi locus.
#spa types with <5 spa repeat.

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