Volume 15, Number 5—May 2009
Letter
Near-Fatal Multiple Organ Dysfunction Syndrome Induced by Plasmodium malariae
Table
Results of genetic screening for single nucleotide polymorphisms known to be associated with sepsis severity in patient with Plasmodium malariae infection, France*
Gene | rs | Wild type | Heterozygous | Homozygous |
---|---|---|---|---|
Pathogen detection | ||||
TLR2 | 5743708 | X | ||
TLR2 | 5743704 | X | ||
TLR4 | 4986790 | X | ||
TLR5 | 5744168 | X | ||
CD14 | 2569190 | X | ||
MD-2 | –1625C/G | X | ||
FcγRIIa | 1801274 | X | ||
MBL2 | 52 A/D | X | ||
MBL2 | 54 A/B | X | ||
MBL2 | 57 A/C | X | ||
MBL2 | –550 H/L | X | ||
MBL2 | –221 X/Y | X | ||
MBL2 |
+4 P/Q |
X |
||
TLR signaling | ||||
IRAK1 | 1059703 | X | ||
TIRAP | 8177374 | X | ||
IκB | 3138053 | X | ||
IκB |
2233406 |
X |
||
Inflammation | ||||
Lymphotoxin α | 909253 | X | ||
TNF α | 1800629 | X | ||
ACE | 17236674 | X | ||
MIF | 755622 | X | ||
IL-6 | 1800795 | X | ||
IL-10 |
1800896 |
X |
||
Coagulation | ||||
PAI-1 | 1799768 | X | ||
Factor V | 6025 | X |
*Except for MD-2 and MBL2, rs is the nomenclature used to describe the variants (initially described by den Dunnen and Antonarakis [4]). TLR, toll-like receptor; MBL2, mannose-binding lectin 2; IRAK-1, interleulin-1 receptor-associated kinase; TIRAP, toll interleukin-1 receptor-associated protein; IκB:, inhibitor of Nf-κB; TNF, tumor necrosis factor; ACE, angiotensin-converting enzyme; MIF, macrophage migration inhibitory factor; IL, interleukin; PAI-1, plaminogen activator inhibitor-1.