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Volume 16, Number 11—November 2010
Research

Decreasing Shigellosis-related Deaths without Shigella spp.–specific Interventions, Asia

Pradip Bardhan, A.S.G. Faruque, Aliya Naheed, and David A. SackComments to Author 
Author affiliations: International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh (P. Bardhan, A.S.G. Faruque, A. Naheed); Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA (D.A. Sack)

Main Article

Table 4

Estimated annual number of deaths and case-fatality rates for hospitalized persons with Shigella infection, Asia, 1990–2009*

Characteristic Age group
0–11 mo 1–4 y
No. persons with diarrhea, × 1,000† 3,771 1,300
No. persons with Shigella infection, × 1,000 (% total persons with diarrhea)† 219 (5.8) 122 (9.4)
No. Shigella spp.–related deaths (95% CI) 1,949 (1,292–2256) 24 (24–305)
Case fatality rate, %‡ 0.89 0.01
Corrected no. Shigella spp.–related deaths, × 1,000 (95% CI)§ (23,24)
 13,643 (9,044–15,792)
 168 (168–2,135)
Total no. Shigella spp.–related deaths (95% CI) 13,811 (9,212–17,927)

*CI, confidence interval.
†Table 1.
‡Table 3.
§Corrected for out-of-hospital deaths.

Main Article

References
  1. Kotloff  KL, Winickoff  JP, Ivanoff  B, Clemens  JD, Swerdlow  DL, Sansonetti  PJ, Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ. 1999;77:651–66.PubMedGoogle Scholar
  2. Ashkenazi  S, Passwell  JH, Harlev  E, Miron  D, Dagan  R, Farzan  N, Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O–specific polysaccharide conjugates in children. J Infect Dis. 1999;179:1565–8. DOIPubMedGoogle Scholar
  3. Kotloff  KL, Taylor  DN, Sztein  MB, Wasserman  SS, Losonsky  GA, Nataro  JP, Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults. Infect Immun. 2002;70:2016–21. DOIPubMedGoogle Scholar
  4. Katz  DE, Coster  TS, Wolf  MK, Trespalacios  FC, Cohen  D, Robins  G, Two studies evaluating the safety and immunogenicity of a live, attenuated Shigella flexneri 2a vaccine (SC602) and excretion of vaccine organisms in North American volunteers. Infect Immun. 2004;72:923–30. DOIPubMedGoogle Scholar
  5. Altboum  Z, Barry  EM, Losonsky  G, Galen  JE, Levine  MM. Attenuated Shigella flexneri 2a delta guaBA strain CVD 1204 expressing enterotoxigenic Escherichia coli (ETEC) CS2 and CS3 fimbriae as a live mucosal vaccine against Shigella and ETEC infection. Infect Immun. 2001;69:3150–8. DOIPubMedGoogle Scholar
  6. Sack  RB, Rahman  M, Yunus  M, Khan  EH. Antimicrobial resistance in organisms causing diarrheal disease. Clin Infect Dis. 1997;24(Suppl 1):S102–5.PubMedGoogle Scholar
  7. Bhattacharya  SK, Sarkar  K, Balakrish  NG, Faruque  AS, Sack  DA. Multidrug-resistant Shigella dysenteriae type 1 in south Asia. Lancet Infect Dis. 2003;3:755. DOIPubMedGoogle Scholar
  8. Dutta  D, Bhattacharya  MK, Dutta  S, Datta  A, Sarkar  D, Bhandari  B, Emergence of multidrug-resistant Shigella dysenteriae type 1 causing sporadic outbreak in and around Kolkata, India. J Health Popul Nutr. 2003;21:79–80.PubMedGoogle Scholar
  9. Koster  FT, Curlin  GC, Aziz  KM, Haque  A. Synergistic impact of measles and diarrhoea on nutrition and mortality in Bangladesh. Bull World Health Organ. 1981;59:901–8.PubMedGoogle Scholar
  10. Mathur  R, Mathur  YN, Verma  SD. An outbreak of shigellosis in central India: higher death rate in post-measles shigellosis. J Diarrhoeal Dis Res. 1989;7:28–9.PubMedGoogle Scholar
  11. Mitra  AK, Alvarez  JO, Wahed  MA, Fuchs  GJ, Stephensen  CB. Predictors of serum retinol in children with shigellosis. Am J Clin Nutr. 1998;68:1088–94.PubMedGoogle Scholar
  12. Larson  CP, Saha  UR, Islam  R, Roy  N. Childhood diarrhoea management practices in Bangladesh: private sector dominance and continued inequities in care. Int J Epidemiol. 2006;35:1430–9. DOIPubMedGoogle Scholar
  13. Victora  CG, Bryce  J, Fontaine  O, Monasch  R. Reducing deaths from diarrhoea through oral rehydration therapy. Bull World Health Organ. 2000;78:1246–55.PubMedGoogle Scholar
  14. Ferreccio  C, Prado  V, Ojeda  A, Cayyazo  M, Abrego  P, Guers  L, Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, Chile. Am J Epidemiol. 1991;134:614–27.PubMedGoogle Scholar
  15. Kosek  M, Bern  C, Guerrant  RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ. 2003;81:197–204.PubMedGoogle Scholar
  16. Punyaratabandhu  P, Vathanophas  K, Varavithya  W, Sangchai  R, Athipanyakom  S, Echeverria  P, Childhood diarrhoea in a low-income urban community in Bangkok: incidence, clinical features, and child caretaker’s behaviours. J Diarrhoeal Dis Res. 1991;9:244–9.PubMedGoogle Scholar
  17. Chen  KC, Lin  CH, Qiao  QX, Zen  NM, Zhen  GK, Chen  GL, The epidemiology of diarrhoeal diseases in southeastern China. J Diarrhoeal Dis Res. 1991;9:94–9.PubMedGoogle Scholar
  18. Rothman  KJ, Greenland  S. Meta-analysis. In: Modern epidemiology. 2nd ed. Philadelphia, Lippincott-Raven; 1998. p. 660–1.
  19. Stuart  A, Ord  JK. Kendall’s advanced theory of statistics. Vol. 1: distribution theory. 6th ed. London: Hodder Arnold; 1994.
  20. Parashar  UD, Hummelman  EG, Bresee  JS, Miller  MA, Glass  RI. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003;9:565–72.PubMedGoogle Scholar
  21. United Nations Population Division. World urbanization prospects. The 2007 revision population database. 2008 [cited 2009 Jun 13]. http://esa.un.org/unup/
  22. von Seidlein  L, Kim  DR, Ali  M, Lee  H, Wang  X, Thiem  VD, A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology. PLoS Med. 2006;3:e353. DOIPubMedGoogle Scholar
  23. Greenwood  BM, Greenwood  AM, Bradley  AK, Tulloch  S, Hayes  R, Oldfield  FS. Deaths in infancy and early childhood in a well-vaccinated, rural, west African population. Ann Trop Paediatr. 1987;7:91–9.PubMedGoogle Scholar
  24. Bennish  ML, Wojtyniak  BJ. Mortality due to shigellosis: community and hospital data. Rev Infect Dis. 1991;13(Suppl 4):S245–51.PubMedGoogle Scholar
  25. Guerin  PJ, Brasher  C, Baron  E, Mic  D, Grimont  F, Ryan  M, Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. Lancet. 2003;362:705–6. DOIPubMedGoogle Scholar
  26. Faruque  AS, Ahmed  AM, Ahmed  T, Islam  MM, Hossain  MI, Roy  SK, Nutrition: basis for healthy children and mothers in Bangladesh. J Health Popul Nutr. 2008;26:325–39.PubMedGoogle Scholar
  27. Jamil  KM, Rahman  AS, Bardhan  PK, Khan  AI, Chowdhury  F, Sarker  SA, Micronutrients and anaemia. J Health Popul Nutr. 2008;26:340–55.PubMedGoogle Scholar
  28. Ram  PK, Crump  JA, Gupta  SK, Miller  MA, Mintz  ED, Part  II. Analysis of data gaps pertaining to Shigella infections in low and medium human development index countries, 1984–2005. Epidemiol Infect. 2008;136:577–603. DOIPubMedGoogle Scholar
  29. Sethabutr  O, Echeverria  P, Hoge  CW, Bodhidatta  L, Pitarangsi  C. Detection of Shigella and enteroinvasive Escherichia coli by PCR in the stools of patients with dysentery in Thailand. J Diarrhoeal Dis Res. 1994;12:265–9.PubMedGoogle Scholar
  30. Caulfield  LE, de Onis  M, Blössner  M, Black  RE. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr. 2004;80:193–8.PubMedGoogle Scholar

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